Chloride intracellular channels (CLICs) are a family of unique proteins, that were suggested to adopt both soluble and membrane-associated forms. Moreover, following this unusual metamorphic change, CLICs were shown to incorporate into membranes and mediate ion conduction in vitro, suggesting multimerization upon membrane insertion. Here, we present a 1.8 Å resolution crystal...
Brami Shay Cahal Aviran Itzhaki Moshe Giladi Eilon D. Kirson Uri Weinberg Adrian Kinzel Yoram Palti 0 Moshe Giladi Tumor-treating fields (TTFields) are alternating electric fields in a specific frequency
, IsraelAnna Shteingauz, Yaara Porat, Tali Voloshin, Rosa S. Schneiderman, Mijal Munster, Einav Zeevi, Noa Kaynan, Karnit Gotlib, Moshe Giladi, Eilon D. Kirson & Yoram PaltiNovocure GmbH, Luzern, SwitzerlandUri ... Scholar Search for Karnit Gotlib in:Nature Research journals • PubMed • Google Scholar Search for Moshe Giladi in:Nature Research journals • PubMed • Google Scholar Search for Eilon D. Kirson in:Nature
-38044 Grenoble, FranceEric Forest AuthorsSearch for Moshe Giladi in:Nature Research journals • PubMed • Google ScholarSearch for Lior Almagor in:Nature Research journals • PubMed • Google ScholarSearch
information Author notes Moshe Giladi and Su Youn Lee contributed equally to this work. AffiliationsDepartment of Physiology and Pharmacology, Tel-Aviv University, Tel-Aviv, 69978, IsraelMoshe Giladi, Yarden ... AuthorsSearch for Moshe Giladi in:Nature Research journals • PubMed • Google Scholar Search for Su Youn Lee in:Nature Research journals • PubMed • Google Scholar Search for Yarden Ariely in:Nature Research
Tumor Treating Fields (TTFields) are an anti-neoplastic treatment modality delivered via application of alternating electric fields using insulated transducer arrays placed directly on the skin in the region surrounding the tumor. A Phase 3 clinical trial has demonstrated the effectiveness of continuous TTFields application in patients with glioblastoma during maintenance...
Na+/Ca2+ exchanger (NCX) proteins mediate Ca2+-fluxes across the cell membrane to maintain Ca2+ homeostasis in many cell types. Eukaryotic NCX contains Ca2+-binding regulatory domains, CBD1 and CBD2. Ca2+ binding to a primary sensor (Ca3-Ca4 sites) on CBD1 activates mammalian NCXs, whereas CALX, a Drosophila NCX ortholog, displays an inhibitory response to regulatory Ca2+. To...
Chaudhry, Eilon D Kirson, Uri Weinberg & Yoram Palti AuthorsSearch for Moshe Giladi in:Nature Research journals • PubMed • Google ScholarSearch for Rosa S Schneiderman in:Nature Research journals • PubMed ... authors, except Yoram Palti are paid employees of Novocure. There are no other known conflicts of interest associated with this publication. Corresponding author Correspondence to Moshe Giladi
Tumor treating fields (TTFields) are low intensity, intermediate frequency, alternating electric fields used to treat cancerous tumors. This novel treatment modality effectively inhibits the growth of solid tumors in vivo and has shown promise in pilot clinical trials in patients with advanced stage solid tumors. TTFields were tested for their potential to inhibit metastatic...
) Moshe Giladi, Yoram Wasserman, Noa Urman, Yaara Porat, Rosa Schneiderman, Mijal Munster, Uri Weinberg, Eilon Kirson, and Yoram Palti; Novocure Ltd., Haifa, Israel Tumor Treating Fields (TTFields) are an
anti-angiogenic and -invasive treatment may have a role in GBM therapy. ET-028. ALTERNATING ELECTRIC FIELDS (TTFIELDS) INHIBIT DNA DAMAGE REPAIR RESPONSE IN CANCER CELL LINES Moshe Giladi, Ailon Tichon ... -029. OVERCOMING CELL SIZE ESCAPE FROM TUMOR TREATING FIELDS USING A VARYING FREQUENCY TREATMENT PARADIGM IN-VITRO Moshe Giladi, Yaara Porat, Rosa Schneiderman, Mijal Munster, Uri Weinberg, Eilon Kirson
