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New clues to the nature of immunoglobulin G4-related disease: a retrospective Japanese multicenter study of baseline clinical features of 334 cases

The aim was to further characterize immunoglobulin G4-related disease (IgG4-RD) by a large-scale multicenter study of its clinical and laboratory features conducted by multidisciplinary physicians of IgG4-RD in Japan. Various specialists retrospectively evaluated IgG4-RD patients diagnosed between 1996 and 2015 in five hospitals by analyzing their baseline clinical features...

New clues to the nature of immunoglobulin G4-related disease: a retrospective Japanese multicenter study of baseline clinical features of 334 cases

The aim was to further characterize immunoglobulin G4-related disease (IgG4-RD) by a large-scale multicenter study of its clinical and laboratory features conducted by multidisciplinary physicians of IgG4-RD in Japan. Various specialists retrospectively evaluated IgG4-RD patients diagnosed between 1996 and 2015 in five hospitals by analyzing their baseline clinical features...

New clues to the nature of immunoglobulin G4-related disease: a retrospective Japanese multicenter study of baseline clinical features of 334 cases

The aim was to further characterize immunoglobulin G4-related disease (IgG4-RD) by a large-scale multicenter study of its clinical and laboratory features conducted by multidisciplinary physicians of IgG4-RD in Japan. Various specialists retrospectively evaluated IgG4-RD patients diagnosed between 1996 and 2015 in five hospitals by analyzing their baseline clinical features...

Factors related to renal cortical atrophy development after glucocorticoid therapy in IgG4-related kidney disease: a retrospective multicenter study

Ichiro Mizushima 0 Motohisa Yamamoto Dai Inoue Shinichi Nishi Yoshinori Taniguchi Yoshifumi Ubara Shoko Matsui Tetsuhiko Yasuno Hitoshi Nakashima Hiroki Takahashi Kazunori Yamada 0 Hideki Nomura Masakazu

Recovery of renal function after glucocorticoid therapy for IgG4-related kidney disease with renal dysfunction

Background Although renal dysfunction in IgG4-related kidney disease (IgG4-RKD) shows rapid resolution with glucocorticoid therapy, little is known about the appropriate initial glucocorticoid dose for induction therapy or long-term renal outcome. Methods We retrospectively examined the differences in recovery of renal function according to the dose of glucocorticoid used for...

Clinical course after corticosteroid therapy in IgG4-related aortitis/periaortitis and periarteritis: a retrospective multicenter study

Ichiro Mizushima 0 Dai Inoue Motohisa Yamamoto Kazunori Yamada 0 Takako Saeki Yoshifumi Ubara Shoko Matsui Yasufumi Masaki Takashi Wada Satomi Kasashima Kenichi Harada Hiroki Takahashi Kenji Notohara

Decreased Expression of Innate Immunity-Related Genes in Peripheral Blood Mononuclear Cells from Patients with IgG4-Related Disease

Background IgG4-related disease (IgG4-RD) is a new clinical entity of unknown etiology characterized by elevated serum IgG4 and tissue infiltration by IgG4-positive plasma cells. Although aberrancies in acquired immune system functions, including increases in Th2 and Treg cytokines observed in patients with IgG4-RD, its true etiology remains unclear. To investigate the...

Immunohistochemical Characteristics of IgG4-Related Tubulointerstitial Nephritis: Detailed Analysis of 20 Japanese Cases

 Hitoshi Nakashima,4 Shinichi Nishi,5 Satoshi Hisano,6 Nobuaki Yamanaka,7 Motohisa Yamamoto,8 Hiroki Takahashi,8 Hisanori Umehara,9 Takao Saito,4 and Takako Saeki10 1Division of Rheumatology, Department of

Evaluation and Clinical Validity of a New Questionnaire for Mikulicz's Disease

2012 Academic Editor: John H. Stone Copyright © 2012 Motohisa Yamamoto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted

Proposal for diagnostic criteria for IgG4-related kidney disease

Nishi, Yutaka Yamaguchi, Satoshi Hisano and Nobuaki Yamanaka (Adviser). Dai Inoue, Motohisa Yamamoto, Hiroki Takahashi and Hideki Nomura collaborated in the study from the viewpoint of their respective

A new conceptualization for Mikulicz's disease as an IgG4-related plasmacytic disease

Mikulicz's disease (MD) has been included within the diagnosis of primary Sjögren's syndrome (SS), but it represents a unique condition involving persistent enlargement of the lacrimal and salivary glands characterized by few autoimmune reactions and good responsiveness to glucocorticoids, leading to the recovery of gland function. Mikulicz's disease was recently reported to be...

Leukoencephalopathy during administration of etanercept for refractory rheumatoid arthritis

Motohisa Yamamoto Hiroki Takahashi Hideki Wakasugi Yasutaka Sukawa Mayuko Saito Chisako Suzuki Yasuyoshi Naishiro Hiroyuki Yamamoto Yasuhisa Shinomura Kohzoh Imai immunosuppression. Because of the

A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details

IgG4-related disease (IgG4RD) is a novel clinical disease entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration by IgG4-positive plasma cells. IgG4RD may be present in a certain proportion of patients with a wide variety of diseases, including Mikulicz’s disease, autoimmune pancreatitis, hypophysitis, Riedel thyroiditis, interstitial...