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Interplay between genetic predisposition, macronutrient intake and type 2 diabetes incidence: analysis within EPIC-InterAct across eight European countries

J. Key 20 & Kay-Tee Khaw 21 & Cecilie Kyrø 22 & Francesca Romana Mancini 13 & Elena Molina-Portillo 7,23 & Neil Murphy 15 & Peter M. Nilsson 24 & N. Charlotte Onland-Moret 25 & Domenico Palli 26

Moderate alcohol consumption is associated with lower chronic disease burden expressed in disability-adjusted life years: a prospective cohort study

The relation of alcohol consumption with disease burden remains debated partly due to opposite associations with cardiovascular disease (CVD) and cancer. The relation of alcohol consumption with disease burden expressed in disability-adjusted life years (DALYs) summarizes opposing associations of alcohol consumption on chronic diseases. This study aimed to investigate the...

Correction: Efficacy and Safety Assessment of the Addition of Bevacizumab to Adjuvant Therapy Agents in Cancer Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

N. Charlotte Onland-Moret Anthonius de Boer Geoffrey Liu Anke Citation: Ahmadizar F, Onland-Moret NC, de Boer A, porting Information files, with the exception of the “Data analysis” subsection, Fig 5

Efficacy and Safety Assessment of the Addition of Bevacizumab to Adjuvant Therapy Agents in Cancer Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Aim To evaluate the efficacy and safety of bevacizumab in the adjuvant cancer therapy setting within different subset of patients. Methods & Design/ Results PubMed, EMBASE, Cochrane and Clinical databases were searched for English language studies of randomized controlled trials comparing bevacizumab and adjuvant therapy with adjuvant therapy alone published from...

Reliability of Serum Metabolites over a Two-Year Period: A Targeted Metabolomic Approach in Fasting and Non-Fasting Samples from EPIC

Objective Although metabolic profiles have been associated with chronic disease risk, lack of temporal stability of metabolite levels could limit their use in epidemiological investigations. The present study aims to evaluate the reliability over a two-year period of 158 metabolites and compare reliability over time in fasting and non-fasting serum samples. Methods Metabolites...

Exposure to Famine at a Young Age and Unhealthy Lifestyle Behavior Later in Life

Background A healthy diet is important for normal growth and development. Exposure to undernutrition during important developmental periods such as childhood and adolescence can have effects later in life. Inhabitants of the west of the Netherlands were exposed to severe undernutrition during the famine in the last winter of the second World War (1944–1945). Objective We...

Gene-specific DNA methylation profiles and LINE-1 hypomethylation are associated with myocardial infarction risk

Background DNA methylation profiles are responsive to environmental stimuli and metabolic shifts. This makes DNA methylation a potential biomarker of environmental-related and lifestyle-driven diseases of adulthood. Therefore, we investigated if white blood cells’ (WBCs) DNA methylation profiles are associated with myocardial infarction (MI) occurrence. Whole-genome DNA...

Low fertility and the risk of type 2 diabetes in women

BACKGROUND Fertility problems are frequently followed by early menopause, and early menopause has been associated with increased risk of type 2 diabetes (T2D). Thus far, it is unknown whether low fertility is independently associated with future T2D risk.

Association between Lifestyle Factors and Quality-Adjusted Life Years in the EPIC-NL Cohort

The aim of our study was to relate four modifiable lifestyle factors (smoking status, body mass index, physical activity and diet) to health expectancy, using quality-adjusted life years (QALYs) in a prospective cohort study. Data of the prospective EPIC-NL study were used, including 33,066 healthy men and women aged 20–70 years at baseline (1993–7), followed until 31-12-2007 for...

Development of Methodology for Disability-Adjusted Life Years (DALYs) Calculation Based on Real-Life Data

Background Disability-Adjusted Life Years (DALYs) have the advantage that effects on total health instead of on a specific disease incidence or mortality can be estimated. Our aim was to address several methodological points related to the computation of DALYs at an individual level in a follow-up study. Methods DALYs were computed for 33,507 men and women aged 20–70 years when...

Interactions between Genetic Variants in AMH and AMHR2 May Modify Age at Natural Menopause

. Broekmans 0 N. Charlotte Onland-Moret 0 John R.B. Perry, Peninsula College of Medicine and Dentistry, United Kingdom 0 1 Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht

Serotonin receptor 3A polymorphism c.-42C > T is associated with severe dyspepsia

Background The association between anxiety and depression related traits and dyspepsia may reflect a common genetic predisposition. Furthermore, genetic factors may contribute to the risk of having increased visceral sensitivity, which has been implicated in dyspeptic symptom generation. Serotonin (5-HT) modulates visceral sensitivity by its action on 5-HT3 receptors...

Variants in Neuropeptide Y Receptor 1 and 5 Are Associated with Nutrient-Specific Food Intake and Are Under Recent Selection in Europeans

There is a large variation in caloric intake and macronutrient preference between individuals and between ethnic groups, and these food intake patterns show a strong heritability. The transition to new food sources during the agriculture revolution around 11,000 years ago probably created selective pressure and shaped the genome of modern humans. One major player in energy...

Hormonal, Metabolic, and Inflammatory Profiles and Endometrial Cancer Risk Within the EPIC Cohort—A Factor Analysis

Bueno-de-Mesquita Frnzel J. B. van Duijnhoven Petra H. M. Peeters N. Charlotte Onland-Moret Maria-Luisa Redondo Nomie Travier Maria-Jose Sanchez Jone M. Altzibar Maria-Dolores Chirlaque Aurelio Barricarte ... Duijnhoven); Julius Center for Health Sciences and Primary Care, Utrecht, the Netherlands (Petra H. M. Peeters, N. Charlotte Onland-Moret); Department of Epidemiology and Biostatistics, School of Public Health

Age at Menopause, Reproductive Life Span, and Type 2 Diabetes Risk: Results from the EPIC-InterAct study

OBJECTIVE Age at menopause is an important determinant of future health outcomes, but little is known about its relationship with type 2 diabetes. We examined the associations of menopausal age and reproductive life span (menopausal age minus menarcheal age) with diabetes risk.

C-Reactive Protein Is Independently Associated With Glucose but Not With Insulin Resistance in Healthy Men


Polymorphisms of the TUB Gene Are Associated with Body Composition and Eating Behavior in Middle-Aged Women

BackgroundThe TUB gene, encoding an evolutionary conserved protein, is highly expressed in the hypothalamus and might act as a transcription factor. Mutations in TUB cause late-onset obesity, insulin-resistance and neurosensory deficits in mice. An association of common variants in the TUB gene with body weight in humans has been reported.Methods/FindingsThe aim was to...

Common Variants in the Type 2 Diabetes KCNQ1 Gene Are Associated with Impairments in Insulin Secretion During Hyperglycaemic Glucose Clamp

Background Genome-wide association studies in Japanese populations recently identified common variants in the KCNQ1 gene to be associated with type 2 diabetes. We examined the association of these variants within KCNQ1 with type 2 diabetes in a Dutch population, investigated their effects on insulin secretion and metabolic traits and on the risk of developing complications in...

Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations

. Monda 13 N. Charlotte Onland-Moret 8 Christopher P. Nelson Jeffrey R. O'Connell 11 Jose Ordovas Inga Peter Annette Peters 4 Jonathan Shaffer Haiqinq Shen 11 Erin Smith Liz Speilotes Fridtjof Thomas