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Phenological Responses to ENSO in the Global Oceans

Phenology relates to the study of timing of periodic events in the life cycle of plants or animals as influenced by environmental conditions and climatic forcing. Phenological metrics provide information essential to quantify variations in the life cycle of these organisms. The metrics also allow us to estimate the speed at which living organisms respond to environmental changes. ...

The Role of Cellular Coupling in the Spontaneous Generation of Electrical Activity in Uterine Tissue

The spontaneous emergence of contraction-inducing electrical activity in the uterus at the beginning of labor remains poorly understood, partly due to the seemingly contradictory observation that isolated uterine cells are not spontaneously active. It is known, however, that the expression of gap junctions increases dramatically in the approach to parturition, by more than one ...

Modelling the interaction of keratinocytes and fibroblasts during normal and abnormal wound healing processes

://rspb.royalsocietypublishing.org/ on November 16, 2014 Modelling the wound healing processes S. N. Menon et al. 3331 PDGF gplraotwelteht-fdaecrtoivred density k and random motility coefficient Dk, the fibrin clot has initial ... supplementary material. We now present a set of numerical results obtained Downloaded from http://rspb.royalsocietypublishing.org/ on November 16, 2014 Modelling the wound healing processes S. N. Menon et al

Associations between CYP2B6 Polymorphisms and Pharmacokinetics after a Single Dose of Nevirapine or Efavirenz in African Americans

BackgroundPolymorphisms in CYP2B6 affect the steady-state plasma concentrations of nevirapine and efavirenz. In many resource-limited countries, a single dose of nevirapine has been widely prescribed to pregnant women at delivery, to reduce mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1). We characterized associations between genetic polymorphisms and ...

Distinct Immunity in Patients with Visceral Leishmaniasis from that in Subclinically Infected and Drug-Cured People: Implications for the Mechanism Underlying Drug Cure

Significant levels of IgG3 and IgG4 and high levels of IgG1 leishmania-specific antibody differentiated the immune states in 10 patients with visceral leishmaniasis from those of virtually all 20 drug-cured and 18 subclinically infected subjects, whereas the level of IgG2 antibody was nondiscriminating. The most extreme “subclinically infected” outlier subsequently developed ...