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Repurposing drugs to treat neurological diseases

, Department of Neurology, Cardiff University, University Hospital of Wales , Heath Park, Cardiff CF14 4XN , UK 1 N. P. Robertson Vol.:(011233456789) Introduction The development of new drugs can be expensive

The economic burden of chronic neurological disease

University, University Hospital of Wales , Heath Park, Cardiff CF14 4XN , UK 1 N. P. Robertson Vol.:(011233456789) - Introduction The overall burden of neurological disease on society is considerable and

Secondary antibody deficiency: a complication of anti-CD20 therapy for neuroinflammation

B-cell depleting anti-CD20 monoclonal antibody therapies are being increasingly used as long-term maintenance therapy for neuroinflammatory disease compared to many non-neurological diseases where they are used as remission-inducing agents. While hypogammaglobulinaemia is known to occur in over half of patients treated with medium to long-term B-cell-depleting therapy (in our...

Cerebral amyloid angiopathy: subtypes, treatment and role in cognitive impairment

, Department of Neurology, Cardiff University, University Hospital of Wales , Heath Park, Cardiff CF14 4XN , UK 1 N. P. Robertson Vol.:(011233456789) Introduction Cerebral amyloid angiopathy (CAA) is

B cell treatments for multiple sclerosis

, UK 1 & N. P. Robertson Introduction The established picture of immunological dysfunction in Multiple Sclerosis (MS) posits a central role for T cells. As a consequence, the development of disease

Dystonia: opportunities to gain insights into underlying pathophysiological mechanisms

, Neurosciences , Cardiff University , Cardiff CF14 4XW , UK 1 & N. P. Robertson Introduction Dystonia is one of the most common movement disorders, a core component of the isolated and combined dystonias as well

Reversing the trend: interventions to treat intracranial haemorrhage associated with anticoagulation

Clinical Neuroscience, Cardiff University, University Hospital of Wales , Heath Park, Cardiff CF14 4XN , UK 1 & N. P. Robertson - Spontaneous intracranial haemorrhage (ICH) is less common as a cause of

Zika virus and neurology: proving cause and effect

University, University Hospital of Wales , Heath Park, Cardiff CF14 4XN , UK 1 & N. P. Robertson - Introduction ‘Zika fever’ was first reported in Uganda and Tanzania in 1952. Caused by the Zika flavivirus

CGRP and migraine

. Robertson - Migraine has been estimated to be the seventh highest cause of disability worldwide, and the third most common disease worldwide after dental caries and tension type headache. However, the use

Continuous evolution of magnetic resonance imaging in multiple sclerosis

Clinical Neuroscience, Cardiff University , Cardiff , UK 1 & N. P. Robertson - Since the introduction of MR imaging into routine clinical practice in the 1990s, it has become firmly embedded into the