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14 papers found.
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Secondary antibody deficiency: a complication of anti-CD20 therapy for neuroinflammation

B-cell depleting anti-CD20 monoclonal antibody therapies are being increasingly used as long-term maintenance therapy for neuroinflammatory disease compared to many non-neurological diseases where they are used as remission-inducing agents. While hypogammaglobulinaemia is known to occur in over half of patients treated with medium to long-term B-cell-depleting therapy (in our...

Repurposing drugs to treat neurological diseases

, Department of Neurology, Cardiff University, University Hospital of Wales , Heath Park, Cardiff CF14 4XN , UK 1 N. P. Robertson Vol.:(011233456789) Introduction The development of new drugs can be expensive

The economic burden of chronic neurological disease

University, University Hospital of Wales , Heath Park, Cardiff CF14 4XN , UK 1 N. P. Robertson Vol.:(011233456789) - Introduction The overall burden of neurological disease on society is considerable and

Cerebral amyloid angiopathy: subtypes, treatment and role in cognitive impairment

, Department of Neurology, Cardiff University, University Hospital of Wales , Heath Park, Cardiff CF14 4XN , UK 1 N. P. Robertson Vol.:(011233456789) Introduction Cerebral amyloid angiopathy (CAA) is

B cell treatments for multiple sclerosis

, UK 1 & N. P. Robertson Introduction The established picture of immunological dysfunction in Multiple Sclerosis (MS) posits a central role for T cells. As a consequence, the development of disease

Dystonia: opportunities to gain insights into underlying pathophysiological mechanisms

, Neurosciences , Cardiff University , Cardiff CF14 4XW , UK 1 & N. P. Robertson Introduction Dystonia is one of the most common movement disorders, a core component of the isolated and combined dystonias as well

Reversing the trend: interventions to treat intracranial haemorrhage associated with anticoagulation

Clinical Neuroscience, Cardiff University, University Hospital of Wales , Heath Park, Cardiff CF14 4XN , UK 1 & N. P. Robertson - Spontaneous intracranial haemorrhage (ICH) is less common as a cause of

Zika virus and neurology: proving cause and effect

University, University Hospital of Wales , Heath Park, Cardiff CF14 4XN , UK 1 & N. P. Robertson - Introduction ‘Zika fever’ was first reported in Uganda and Tanzania in 1952. Caused by the Zika flavivirus

Continuous evolution of magnetic resonance imaging in multiple sclerosis

Clinical Neuroscience, Cardiff University , Cardiff , UK 1 & N. P. Robertson - Since the introduction of MR imaging into routine clinical practice in the 1990s, it has become firmly embedded into the

CGRP and migraine

. Robertson - Migraine has been estimated to be the seventh highest cause of disability worldwide, and the third most common disease worldwide after dental caries and tension type headache. However, the use