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Lipidomic profiling reveals free fatty acid alterations in plasma from patients with atrial fibrillation

, Youngjin Cho, Nami Kim, Il-Young Oh, Sang Won Kang, Eue Keun Choi, Geum-Sook Hwang. Formal analysis: Youngjin Cho, Nami Kim, Il-Young Oh, Sang Won Kang, Eue-Keun Choi, Geum-Sook Hwang. Funding ... acquisition: Eue-Keun Choi, Geum-Sook Hwang. Investigation: Youngae Jung, Youngjin Cho, Nami Kim, Il-Young Oh. Methodology: Youngae Jung, Youngjin Cho, Nami Kim, Il-Young Oh. Project administration: Youngae

S(e)oul Search: The Changing Religious Landscape in Seoul and Its Implications for Defining “Asia”

There is a saying that if one looks at Seoul at night from afar, one will see a large city covered with neon-lit red crosses. It is also said that a Christian church can be found on every other block in the streets of Seoul, the capital of the Republic of Korea (also known as South Korea). To be sure, this is not the case. Yet this embellished illustration of Seoul as a Christian...

Alcohol induces cell proliferation via hypermethylation of ADHFE1 in colorectal cancer cells

Background The hypermethylation of Alcohol dehydrogenase iron containing 1 (ADHFE1) was recently reported to be associated with colorectal cancer (CRC) differentiation. However, the effect of alcohol on ADHFE1 hypermethylation in CRC is still unclear. Methods The methylation status and expression levels of ADHFE1 were investigated in primary tumor tissues and adjacent normal...

Dibenzoylmethane Exerts Metabolic Activity through Regulation of AMP-Activated Protein Kinase (AMPK)-Mediated Glucose Uptake and Adipogenesis Pathways

Dibenzoylmethane (DBM) has been shown to exert a variety of beneficial effects on human health. However, the mechanism of action is poorly understood. In this study, DBM increased phosphorylation of AMP-activated protein kinase (AMPK) and stimulated glucose uptake in a skeletal muscle cell line. Both knockdown of AMPK with siRNA and inhibition with AMPK inhibitor blocked DBM...

Identification of novel hypermethylated genes and demethylating effect of vincristine in colorectal cancer

Background Colorectal cancer (CRC) arises as a consequence of genetic events such as gene mutation and epigenetic alteration. The aim of this study was to identify new hypermethylated candidate genes and methylation-based therapeutic targets using vincristine in CRC. Methods We analyzed the methylation status of 27,578 CpG sites spanning more than 14,000 genes in CRC tissues...