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151 papers found.
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Novel circulating microRNAs expression profile in colon cancer: a pilot study

To identify the expression profile of novel microRNAs (miRNAs) in colon cancer and evaluate their clinical applicability. Differences in the expression of serum miRNAs in patients with colon cancer and healthy controls were identified using miRNA microarrays. Differentially expressed miRNAs were verified via real-time polymerase chain reaction (PCR) using sera from 50 patients...

Novel circulating microRNAs expression profile in colon cancer: a pilot study

To identify the expression profile of novel microRNAs (miRNAs) in colon cancer and evaluate their clinical applicability. Differences in the expression of serum miRNAs in patients with colon cancer and healthy controls were identified using miRNA microarrays. Differentially expressed miRNAs were verified via real-time polymerase chain reaction (PCR) using sera from 50 patients...

Tuned and non-Higgsable U(1)s in F-theory

We study the tuning of U(1) gauge fields in F-theory models on a base of general dimension. We construct a formula that computes the change in Weierstrass moduli when such a U(1) is tuned, based on the Morrison-Park form of a Weierstrass model with an additional rational section. Using this formula, we propose the form of “minimal tuning” on any base, which corresponds to the...

Photosynthetic gas exchange responses of Swietenia macrophylla King and Melia azedarach L. plantations under drought conditions

Background The environmental stresses caused by climate change have become more severe in recent decades, affecting tree growth and physiology. Tropical forests have great potential for global carbon sequestration. However, they suffer from heavy rainfall and prolonged dry periods due to climate change. Swietenia macrophylla King and Melia azedarach L. are economically valuable...

MicroRNA signatures of endogenous Huntingtin CAG repeat expansion in mice

, Giovanni Coppola, Steve Horvath. Formal analysis: Peter Langfelder, Steve Horvath, X. William Yang. Funding acquisition: X. William Yang. Investigation: Nan Wang, X. William Yang. Methodology: Peter

Gaussian-binary restricted Boltzmann machines for modeling natural image statistics

sampling algorithms for training GRBMs and show that Contrastive Divergence performs better than training methods that use a persistent Markov chain. - Funding: Author Nan Wang was employed by Institut ... fuÈr Neuroinformatik, Ruhr- UniversitaÈt at Bochum at the time of the study and is now employed by Zalando SE. Zalando SE provided no financial support for the study. Nan Wang was supported by a

Analytical formulation of lunar cratering asymmetries

A&A Astronomy & Astrophysics Nan Wang 0 Ji-Lin Zhou (hN—) 0 0 School of Astronomy and Space Science and Key Laboratory of Modern Astronomy and Astrophysics in Ministry of Education, Nanjing

Modified human glucagon-like peptide-1 (GLP-1) produced in E. coli has a long-acting therapeutic effect in type 2 diabetic mice

abbreviations in alphabetical order. (XLSX) Author Contributions Conceptualization: Dehu Liu. Data curation: Fangfang Xu, Nan Wang, Gangqiang Li. Formal analysis: Fangfang Xu, Kevin Yueju Wang, Nan Wang ... . Funding acquisition: Dehu Liu. Investigation: Dehu Liu. Methodology: Fangfang Xu, Nan Wang, Gangqiang Li. Resources: Nan Wang. Supervision: Kevin Yueju Wang. Writing ± original draft: Fangfang Xu, Kevin

Authenticity and Relationship Satisfaction: Two Distinct Ways of Directing Power to Self-Esteem

Possessing power contributes to high self-esteem, but how power enhances self-esteem is still unknown. As power is associated with both self-oriented goals and social-responsibility goals, we proposed that power predicts self-esteem through two positive personal and interpersonal results: authenticity and relationship satisfaction. Three studies were carried out with a total of...

Transcriptomic analysis of the response of Pseudomonas fluorescens to epigallocatechin gallate by RNA-seq

Epigallocatechin gallate (EGCG) is a main constituent of green tea polyphenols that are widely used as food preservatives and are considered to be safe for consumption. However, the underlying antimicrobial mechanism of EGCG and the bacterial response to EGCG are not clearly understood. In the present study, a genome-wide transcriptional analysis of a typical spoilage bacterium...

Expression of a fungal manganese peroxidase in Escherichia coli: a comparison between the soluble and refolded enzymes

Background Manganese peroxidase (MnP) from Irpex lacteus F17 has been shown to have a strong ability to degrade recalcitrant aromatic pollutants. In this study, a recombinant MnP from I. lacteus F17 was expressed in Escherichia coli Rosetta (DE3) in the form of inclusion bodies, which were refolded to achieve an active enzyme. Further, we optimized the in vitro refolding...

A Monte Carlo exploration of threefold base geometries for 4d F-theory vacua

We use Monte Carlo methods to explore the set of toric threefold bases that support elliptic Calabi-Yau fourfolds for F-theory compactifications to four dimensions, and study the distribution of geometrically non-Higgsable gauge groups, matter, and quiver structure. We estimate the number of distinct threefold bases in the connected set studied to be ∼ 1048. The distribution of...

The F-theory geometry with most flux vacua

Applying the Ashok-Denef-Douglas estimation method to elliptic Calabi-Yau fourfolds suggests that a single elliptic fourfold \( {\mathrm{\mathcal{M}}}_{\max } \) gives rise to \( \mathcal{O}\left({10}^{272,000}\right) \) F-theory flux vacua, and that the sum total of the numbers of flux vacua from all other F-theory geometries is suppressed by a relative factor of \( \mathcal{O...

Generalized Cartan Calculus in general dimension

We develop the generalized Cartan Calculus for the groups \( G=\mathrm{S}\mathrm{L}\left(2,\mathrm{\mathbb{R}}\right)\times {\mathrm{\mathbb{R}}}^{+},\mathrm{S}\mathrm{L}\left(5,\mathrm{\mathbb{R}}\right) \) and SO(5, 5). They are the underlying algebraic structures of d = 9, 7, 6 exceptional field theory, respectively. These algebraic identities are needed for the “tensor...

The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection

Zhang, Pan Yang, Nan Wang, Jialong Zhang, Jingyun Li, Hao Guo, Xiangyun Yin, Zihe Rao, Xiangxi Wang, and Liguo Zhang declare that they have no conflict of interest. This article does not contain any

Estimation of basal metabolic rate in Chinese: are the current prediction equations applicable?

Background Measurement of basal metabolic rate (BMR) is suggested as a tool to estimate energy requirements. Therefore, BMR prediction equations have been developed in multiple populations because indirect calorimetry is not always feasible. However, there is a paucity of data on BMR measured in overweight and obese adults living in Asia and equations developed for this group of...

Bioactivity of a modified human Glucagon-like peptide-1

Diabetes has become the third largest cause of death in humans worldwide. Therefore, effective treatment for this disease remains a critical issue. Glucagon-like peptide-1 (GLP-1) plays an important role in glucose homeostasis, and therefore represents a promising candidate to use for the treatment of diabetes. Native GLP-1, however, is quickly degraded in in the circulatory...

A comparative study of k-spectrum-based error correction methods for next-generation sequencing data analysis

Background Innumerable opportunities for new genomic research have been stimulated by advancement in high-throughput next-generation sequencing (NGS). However, the pitfall of NGS data abundance is the complication of distinction between true biological variants and sequence error alterations during downstream analysis. Many error correction methods have been developed to correct...