technologies. Author Contributions Conceptualization: Jan Scott, Nicholas Martin, Nathan A. Gillespie, Ian B. Hickie. Formal analysis: Jan Scott, Jacob J. Crouse, Nicholas Ho. Funding acquisition: Nicholas ... Martin, Nathan A. Gillespie. Investigation: Richard Parker, John McGrath, Nathan A. Gillespie, Sarah Medland. Methodology: Jan Scott, Jacob J. Crouse, Nicholas Ho, Ian B. Hickie. Project administration
Background The relative contributions of genetics and environment to asthma in Hispanics or to asthma in children younger than 3 years are not well understood. Objective To examine the relative contributions of genetics and environment to early-childhood asthma by performing a longitudinal twin study of asthma in Puerto Rican children ≤3 years old. Methods 678 twin infants from...
Head motion (HM) is a well known confound in analyses of functional MRI (fMRI) data. Neuroimaging researchers therefore typically treat HM as a nuisance covariate in their analyses. Even so, it is possible that HM shares a common genetic influence with the trait of interest. Here we investigate the extent to which this relationship is due to shared genetic factors, using HM...
Hair cortisol concentration (HCC) is a promising measure of long-term hypothalamus-pituitary-adrenal (HPA) axis activity. Previous research has suggested an association between HCC and psychological variables, and initial studies of inter-individual variance in HCC have implicated genetic factors. However, whether HCC and psychological variables share genetic risk factors remains...
Gelernter , Dorret I. Boomsma, Nicholas G. Martin, Stuart MacGregor , John R. B. Perry, Abraham A. Palmer , Danielle Posthuma , Marcus R. Munafò , Nathan A. Gillespie, Eske M. Derks and
, Brien P Riley, Nathan A Gillespie & John M HettemaDepartments of Biomedical Informatics and Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USAAn-Yuan Guo & Zhongming ZhaoDepartment ... • Google ScholarSearch for Brien P Riley in:Nature Research journals • PubMed • Google ScholarSearch for Nathan A Gillespie in:Nature Research journals • PubMed • Google ScholarSearch for Carol A Prescott
The volume of the lateral ventricles (LV) increases with age and their abnormal enlargement is a key feature of several neurological and psychiatric diseases. Although lateral ventricular volume is heritable, a comprehensive investigation of its genetic determinants is lacking. In this meta-analysis of genome-wide association studies of 23,533 healthy middle-aged to elderly...
General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16–102) and find 148 genome-wide significant independent loci (P < 5 × 10−8) associated with general cognitive function. Within the novel...