Loading...
Non-alcoholic fatty liver disease (NAFLD) is a leading form of chronic liver disease with large unmet need. Non-alcoholic steatohepatitis (NASH), a progressive variant of NAFLD, can lead to fibrosis, cirrhosis, and hepatocellular carcinoma. To identify potential new therapeutics for NASH, we used a computational approach based on Connectivity Map (CMAP) analysis, which pointed us...
, Bao Hoang, Vinod Kumar, Mark R. Hurle, Sarah O?Donnell, Anna Vossenka?mper, Lin Wang. Project administration: Neetu Rajpal, Thomas T. MacDonald, Mike Reilly, Bart J. Votta. Resources: Qing Xie, Neetu ... . Writing ? original draft: William C. Reisdorf, Qing Xie, Deepak K. Rajpal, Yolanda Sanchez. Writing ? review & editing: William C. Reisdorf, Qing Xie, Xin Zeng, Wensheng Xie, Neetu Rajpal, Bao Hoang, Mark E
In addition to classic functions of facilitating hepatobiliary secretion and intestinal absorption of lipophilic nutrients, bile acids (BA) are also endocrine factors and regulate glucose and lipid metabolism. Recent data indicate that antiobesity bariatric procedures e.g. Roux-en-Y gastric bypass surgery (RYGB), which also remit diabetes, increase plasma BAs in humans, leading...