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In vitro and in vivo toxicity assessment of nanoparticles

Nanotechnology has revolutionized gene therapy, diagnostics and environmental remediation. Their bulk production, uses and disposal have posed threat to the environment. With the appearance of these nanoparticles in the environment, their toxicity assessment is an immediate concern. This review is an attempt to summarize the major techniques used in cytotoxity determination. The...

Data mining models for predicting oral cancer survivability

In this paper, three predictive models are proposed to identify the most effective model for predicting the survival rate of oral cancer in patients who visit the ENT OPD. This study examined 1,024 patients who visited a tertiary care center during Jan 2004 and Dec 2009. The predictive models developed in this work are Single Tree, Decision Tree Forest and TreeBoost based on...

Systematic CpT (ApG) Depletion and CpG Excess Are Unique Genomic Signatures of Large DNA Viruses Infecting Invertebrates

Differences in the relative abundance of dinucleotides, if any may provide important clues on host-driven evolution of viruses. We studied dinucleotide frequencies of large DNA viruses infecting vertebrates (n = 105; viruses infecting mammals = 99; viruses infecting aves = 6; viruses infecting reptiles = 1) and invertebrates (n = 88; viruses infecting insects = 84; viruses...

A molecular systems approach to modelling human skin pigmentation: identifying underlying pathways and critical components

Background Ultraviolet radiations (UV) serve as an environmental stress for human skin, and result in melanogenesis, with the pigment melanin having protective effects against UV induced damage. This involves a dynamic and complex regulation of various biological processes that results in the expression of melanin in the outer most layers of the epidermis, where it can exert its...

NGS Transcriptomes and Enzyme Inhibitors Unravel Complexity of Picrosides Biosynthesis in Picrorhiza kurroa Royle ex. Benth

Picrorhiza kurroa is an important medicinal herb valued for iridoid glycosides, Picroside-I (P-I) and Picroside-II (P-II), which have several pharmacological activities. Genetic interventions for developing a picroside production platform would require knowledge on biosynthetic pathway and key control points, which does not exist as of today. The current study reports that...

Simultaneous quantification of triterpenoic acids by high performance liquid chromatography method in the extracts of gum resin of Boswellia serrata obtained by different extraction techniques

manuscript. All authors read and approved the final manuscript. Acknowledgements This work is dedicated to our colleague late Dr. R K Khajuria, Chief Scientist, CSIR-IIIM, Jammu. One of the authors, Neha ... Sharma is highly thankful to the Department of Science and Technology, New Delhi for the award of INSPIRE fellowship. Competing interests The authors declare that they have no competing interests. 1

The Lancet Weight Determines Wheal Diameter in Response to Skin Prick Testing with Histamine

Background Skin prick test (SPT) is a common test for diagnosing immunoglobulin E-mediated allergies. In clinical routine, technicalities, human errors or patient-related biases, occasionally results in suboptimal diagnosis of sensitization. Objective Although not previously assessed qualitatively, lancet weight is hypothesized to be important when performing SPT to minimize the...

Concentration dependent Electrospray Ionisation Mass Spectrometry and Tandem Mass Spectrometry (MS/MS ) studies on (E,E)-1-[5-(1,3-benzodioxol-5yl)-1-oxo-2,4-pentadienyl]- piperidine (Piperine) and its analogues

Studies on piperine ((M 1 )) and its synthetic analogues (M 2–18 ) by positive electrospray ionisation mass spectrometry were carried out in the flow injection mode of analysis in methanol. The MS experiments on these compounds at concentration 5 ng/μL or above yielded dimeric ionic species [2 M + Na]+ which revealed that piperine and its analogues exhibit clustering of ions when...

Compatibility of Metarhizium anisopliae (Metsch.) Sorok. with Ocimum sanctum Linn. (Tulsi) (Lamiaceae) Extracts

The compatibility of Metarhizium anisopliae with Ocimum sanctum was studied in vitro. Leaves, roots, stems and seed extracts of O. sanctum were mixed in a Potato Dextrose Agar and Potato Dextrose Broth. M. anisopliae was inoculated and the mycelial dry weight and spore count were assessed. The behavior of the fungus with the extracts was similar in terms of mycelial dry weight...

Proteome scale comparative modeling for conserved drug and vaccine targets identification in Corynebacterium pseudotuberculosis

Corynebacterium pseudotuberculosis (Cp) is a pathogenic bacterium that causes caseous lymphadenitis (CLA), ulcerative lymphangitis, mastitis, and edematous to a broad spectrum of hosts, including ruminants, thereby threatening economic and dairy industries worldwide. Currently there is no effective drug or vaccine available against Cp. To identify new targets, we adopted a novel...