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Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer

Giovannetti), Istituto Toscano Tumori grant (Ugo Boggi, Niccola Funel, Elisa Giovannetti), European Union iCARE Marie Curie grant (Leticia G. Leon), CCA Foundation 2015 (Elisa Giovannetti), Tuscany Region grant ... FAS Health (Ugo Boggi, Niccola Funel, Elisa Giovannetti). Availability of data and materials All data generated or analysed during this study are included in this published article (and its

MicroRNA profiling of primary pulmonary enteric adenocarcinoma in members from the same family reveals some similarities to pancreatic adenocarcinoma—a step towards personalized therapy

towards personalized therapy Ingrid Garajová 1 4 Niccola Funel 2 3 Michelangelo Fiorentino 8 Valentina Agostini 8 Manuela Ferracin 6 7 Massimo Negrini 6 7 Giovanni Luca Frassineti 10 Giampaolo Gavelli 9 ... the manuscript to be published. Acknowledgements This work was partially supported by grants from Istituto Toscano Tumori (ITT) and AIRC Start-Up grant (to Niccola Funel and Elisa Giovannetti). Submit

AKT1 and SELP Polymorphisms Predict the Risk of Developing Cachexia in Pancreatic Cancer Patients

Giovannetti, Niccola Funel, Ugo Boggi) and AIRC Start-Up grant (Elisa Giovannetti). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

Vascular Dysfunction in a Mouse Model of Rett Syndrome and Effects of Curcumin Treatment

Mutations in the coding sequence of the X-linked gene MeCP2 (Methyl CpG–binding protein) are present in around 80% of patients with Rett Syndrome, a common cause of intellectual disability in female and to date without any effective pharmacological treatment. A relevant, and so far unexplored feature of RTT patients, is a marked reduction in peripheral circulation. To investigate...

Role of CYB5A in Pancreatic Cancer Prognosis and Autophagy Modulation

Background Loss of 18q22.3 is a prognostic marker in pancreatic ductal adenocarcinoma (PDAC). This study investigated genes encoded by this cytoband.

Mutational Profiling of Kinases in Human Tumours of Pancreatic Origin Identifies Candidate Cancer Genes in Ductal and Ampulla of Vater Carcinomas

Background Protein kinases are key regulators of cellular processes (such as proliferation, apoptosis and invasion) that are often deregulated in human cancers. Accordingly, kinase genes have been the first to be systematically analyzed in human tumors leading to the discovery that many oncogenes correspond to mutated kinases. In most cases the genetic alterations translate in...

High-Throughput MicroRNA (miRNAs) Arrays Unravel the Prognostic Role of MiR-211 in Pancreatic Cancer

, Godefridus J Peters), AIRC Marie Curie International Fellowship (Elisa Giovannetti), and Italian Minister of Research, PRIN-2009 (Elisa Giovannetti, Niccola Funel, Ugo Boggi). Toray Industries, Inc. is a

Identification of MicroRNA-21 as a Biomarker for Chemoresistance and Clinical Outcome Following Adjuvant Therapy in Resectable Pancreatic Cancer

Background Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis. The high risk of recurrence following surgical resection provides the rationale for adjuvant therapy. However, only a subset of patients benefit from adjuvant therapy. Identification of molecular markers to predict treatment outcome is therefore warranted. The aim of the present study was to evaluate...