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Targeted delivery of mannosylated-PLGA nanoparticles of antiretroviral drug to brain

Targeted delivery of mannosylated-PLGA nanoparticles of anti-retroviral drug to brain Bhavin K Patel, Rajesh H Parikh, Nilesh Patel Department of Pharmaceutics and Pharmaceutical Technology ... delivery of the drug into brain macrophages. - Bhavin K patel rajesh h parikh Nilesh patel Department of pharmaceutics and pharmaceutical Technology, r amanbhai patel College of pharmacy, Charotar

A Comparison of Drug Transport in Pulmonary Absorption Models: Isolated Perfused rat Lungs, Respiratory Epithelial Cell Lines and Primary Cell Culture

Purpose To evaluate the ability of human airway epithelial cell layers and a simple rat isolated perfused lung (IPL) model to predict pulmonary drug absorption in rats in vivo. Method The permeability of seven compounds selected to possess a range of lipophilicity was measured in two airway cell lines (Calu-3 and 16HBE14o-), in normal human bronchial epithelial (NHBE) cells and...

Use of 4-factor prothrombin complex concentrate in the treatment of a gastrointestinal hemorrhage complicated by dabigatran

Target-specific oral anticoagulants (TSOACs) provide patients and healthcare providers with an alternative to vitamin K antagonists (VKA). The TSOACs are of similar or superior efficacy to warfarin, but unlike VKAs, there are no approved ‘antidotes’ for rapid reversal of life-threatening bleeding on therapy. We report here the case of an 83-year-old gentleman, who presented to...