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Coordinated inhibition of C/EBP by Tribbles in multiple tissues is essential for Caenorhabditis elegans development

Background Tribbles proteins are conserved pseudokinases that function to control kinase signalling and transcription in diverse biological processes. Abnormal function in human Tribbles has been implicated in a number of diseases including leukaemia, metabolic syndromes and cardiovascular diseases. Caenorhabditis elegans Tribbles NIPI-3 was previously shown to activate host...

Coordinated inhibition of C/EBP by Tribbles in multiple tissues is essential for Caenorhabditis elegans development

Background Tribbles proteins are conserved pseudokinases that function to control kinase signalling and transcription in diverse biological processes. Abnormal function in human Tribbles has been implicated in a number of diseases including leukaemia, metabolic syndromes and cardiovascular diseases. Caenorhabditis elegans Tribbles NIPI-3 was previously shown to activate host...

A quantitative genome-wide RNAi screen in C. elegans for antifungal innate immunity genes

Université UM2, Inserm, U1104, CNRS UMR7280 , 13288 Marseille , France 1 Olivier Zugasti and Nishant Thakur are co-first authors 2 Present address: Section of Hematology/Oncology, Department of Pediatrics

VIRsiRNApred: a web server for predicting inhibition efficacy of siRNAs targeting human viruses

Background Selection of effective viral siRNA is an indispensable step in the development of siRNA based antiviral therapeutics. Despite immense potential, a viral siRNA efficacy prediction algorithm is still not available. Moreover, performances of the existing general mammalian siRNA efficacy predictors are not satisfactory for viral siRNAs. Therefore, we have developed...

HIPdb: A Database of Experimentally Validated HIV Inhibiting Peptides

Background Besides antiretroviral drugs, peptides have also demonstrated potential to inhibit the Human immunodeficiency virus (HIV). For example, T20 has been discovered to effectively block the HIV entry and was approved by the FDA as a novel anti-HIV peptide (AHP). We have collated all experimental information on AHPs at a single platform. Descriptions HIPdb is a manually...

VIRmiRNA: a comprehensive resource for experimentally validated viral miRNAs and their targets

Viral microRNAs (miRNAs) regulate gene expression of viral and/or host genes to benefit the virus. Hence, miRNAs play a key role in host–virus interactions and pathogenesis of viral diseases. Lately, miRNAs have also shown potential as important targets for the development of novel antiviral therapeutics. Although several miRNA and their target repositories are available for...

AVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses

Antiviral peptides (AVPs) have exhibited huge potential in inhibiting viruses by targeting various stages of their life cycle. Therefore, we have developed AVPdb, available online at http://crdd.osdd.net/servers/avpdb, to provide a dedicated resource of experimentally verified AVPs targeting over 60 medically important viruses including Influenza, HCV, HSV, RSV, HBV, DENV, SARS...

AVPpred: collection and prediction of highly effective antiviral peptides

Nishant Thakur 0 Abid Qureshi 0 Manoj Kumar 0 0 Bioinformatics Centre, CSIR-Institute of Microbial Technology , Sector 39-A, Chandigarh 160036, India In the battle against viruses, antiviral

VIRsiRNAdb: a curated database of experimentally validated viral siRNA/shRNA

Nishant Thakur 0 Abid Qureshi 0 Manoj Kumar 0 0 Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR) , Sector 39-A, Chandigarh-160036, India

HIVsirDB: A Database of HIV Inhibiting siRNAs

Background Human immunodeficiency virus (HIV) is responsible for millions of deaths every year. The current treatment involves the use of multiple antiretroviral agents that may harm patients due to their toxic nature. RNA interference (RNAi) is a potent candidate for the future treatment of HIV, uses short interfering RNA (siRNA/shRNA) for silencing HIV genes. In this study...