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Accordance to the Dietary Approaches to Stop Hypertension diet pattern and cardiovascular disease in a British, population-based cohort

The dietary approaches to stop hypertension (DASH) diet could be an important population-level strategy to reduce cardiovascular disease (CVD) in the UK, but there is little UK-based evidence on this diet pattern in relation to CVD risk. We tested whether dietary accordance with DASH was associated with risk of CVD in a population-based sample of 23,655 UK adults. This...

Does exposure to the food environment differ by socioeconomic position? Comparing area-based and person-centred metrics in the Fenland Study, UK

Thomas Burgoine 0 Tarra L. Penney 0 Nita G. Forouhi Pablo Monsivais 0 0 UKCRC Centre for Diet and Activity Research (CEDAR), MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine

Interplay between genetic predisposition, macronutrient intake and type 2 diabetes incidence: analysis within EPIC-InterAct across eight European countries

; Macronutrient - Nita G. Forouhi and Nicholas J. Wareham are joint senior authors. Abbreviations EPIC European Prospective Investigation into Cancer and Nutrition GRS Genetic risk score Introduction Genetic

Egg consumption and risk of type 2 diabetes: a prospective study and dose–response meta-analysis

Aims/hypothesis In this study, we aimed to investigate the association between egg consumption and type 2 diabetes risk in the Cohort of Swedish Men and to conduct a meta-analysis to summarise available prospective evidence on this association. Methods We followed 39,610 men (aged 45–79 years) from 1998 up to 2012 for incident type 2 diabetes. Egg consumption was assessed at...

Positive association between artificially sweetened beverage consumption and incidence of diabetes. Reply to Sylvetsky Meni AC, Swithers SE, Rother KI [letter]

O'Connor 0 Nita G. Forouhi 0 0 Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science , Cambridge Biomedical Campus ... , Cambridge CB2 0QQ , UK 1 Nita G. Forouhi Artificially-sweetened beverages; Epidemiology; Sugar-sweetened beverages; Type 2 diabetes - Abbreviations ASB Artificially sweetened beverages SSB Sugar-sweetened

The EPIC-InterAct Study: A Study of the Interplay between Genetic and Lifestyle Behavioral Factors on the Risk of Type 2 Diabetes in European Populations

Nita G. Forouhi Nicholas J. Wareham The rising prevalence of type 2 diabetes around the world and the global pattern of variation in risk between countries have been widely attributed to an ... MC_UU_12015/5 and MC_UU_12015/1). Compliance with Ethics Guidelines Conflict of Interest Nita G. Forouhi and Nicholas J. Wareham declare that they have no conflict of interest. Human and Animal Rights and

Fish consumption and frying of fish in relation to type 2 diabetes incidence: a prospective cohort study of Swedish men

Purpose Epidemiological evidence on the association between fish consumption and risk of type 2 diabetes is heterogeneous across geographical regions. Differences related to fish consumption pattern could possibly help explain the discrepancy between the findings. We therefore aimed to investigate the association between fish consumption (total, fried, specific fish items) and...

Prospective associations and population impact of sweet beverage intake and type 2 diabetes, and effects of substitutions with alternative beverages

Aims/hypothesis This study aimed to evaluate the association of types of sugar-sweetened beverages (SSB) (soft drinks, sweetened-milk beverages, sweetened tea/coffee), artificially sweetened beverages (ASB) and fruit juice with incident type 2 diabetes and determine the effects of substituting non-SSB for SSB and the population-attributable fraction of type 2 diabetes due to...

Age trajectories of glycaemic traits in non-diabetic South Asian and white individuals: the Whitehall II cohort study

Aims/hypothesis South Asian individuals have an increased prevalence of type 2 diabetes, but little is known about the development of glycaemic traits in this ethnic group. We compared age-related changes in glycaemic traits between non-diabetic South Asian and white participants. Methods In a prospective British occupational cohort with 5-yearly clinical examinations (n = 230/5...

The Impact of Health Behaviours on Incident Cardiovascular Disease in Europeans and South Asians – A Prospective Analysis in the UK SABRE Study

Background There is consistent evidence on the impact of health behaviours on risk of cardiovascular disease (CVD) in European populations. As South Asians in the UK have an excess risk of CVD and coronary heart disease (CHD) compared to Europeans, we investigated whether a similar association between combined health behaviours and risk of CVD and CHD among this high-risk group...

Diabetes risk and amino acid profiles: cross-sectional and prospective analyses of ethnicity, amino acids and diabetes in a South Asian and European cohort from the SABRE (Southall And Brent REvisited) Study

Aims/hypothesis South Asian individuals have an increased risk of diabetes compared with Europeans that is unexplained by obesity and traditional or established metabolic measures. Circulating amino acids (AAs) may provide additional explanatory insights. In a unique cohort of European and South Asian men, we compared cross-sectional associations between AAs, metabolic and...

Socioeconomic status, financial hardship and measured obesity in older adults: a cross-sectional study of the EPIC-Norfolk cohort

Background Socioeconomic status is strongly associated with obesity. Current economic circumstances are also independently associated with self-reported weight status in Finnish civil servants. We aimed to examine three types of financial hardship in relation to measured general and central obesity in a general population of older adults, while considering conventional...

Dietary dairy product intake and incident type 2 diabetes: a prospective study using dietary data from a 7-day food diary

Laura M. O'Connor Marleen A. H. Lentjes Robert N. Luben Kay-Tee Khaw Nicholas J. Wareham Nita G. Forouhi 0 ) MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of

Definitions and potential health benefits of the Mediterranean diet: views from experts around the world

definition [10,38]. Competing interests MAM declares that he has no competing interests. The importance of redefining the Mediterranean diet in epidemiology Tammy YN Tong, Nita G Forouhi (Figures 3 and 4 ... Forouhi 6 Shweta Khandelwal 5 Dorairaj Prabhakaran 5 Dariush Mozaffarian 4 Michel de Lorgeril 3 0 CIBER-OBN, Instituto de Salud Carlos III , Madrid , Spain 1 Department of Preventive Medicine and Public

Ethnic Differences in Disability Prevalence and Their Determinants Studied over a 20-Year Period: A Cohort Study

Background To compare disability prevalence rates in the major ethnic groups in the UK and understand the risk factors contributing to differences identified. It was hypothesised that Indian Asian and African Caribbean people would experience higher rates of disability compared with Europeans. Methods Data was collected from 888 European, 636 Indian Asian and 265 African...

Fish Consumption, Dietary Long-Chain n-3 Fatty Acids, and Risk of Type 2 Diabetes: Systematic review and meta-analysis of prospective studies

ALICE WALLIN MSC DANIELA DI GIUSEPPE MSC NICOLA ORSINI PHD PINAL S. PATEL MPHIL NITA G. FOROUHI FFPH ALICJA WOLK DMSC R e v i e w s / C o n s e n s u s OBJECTIVEdThe evidence on the association

Development and validation of a robust automated analysis of plasma phospholipid fatty acids for metabolic phenotyping of large epidemiological studies

A fully automated, high-throughput method was developed to profile the fatty acids of phospholipids from human plasma samples for application to a large epidemiological sample set (n > 25,000). We report here on the data obtained for the quality-control materials used with the first 860 batches, and the validation process used. The method consists of two robotic systems combined...

Insulin Resistance and Truncal Obesity as Important Determinants of the Greater Incidence of Diabetes in Indian Asians and African Caribbeans Compared With Europeans: The Southall And Brent REvisited (SABRE) cohort

THERESE TILLIN MSC MB BS ALUN D. HUGHES PHD MB BS BSC IAN F. GODSLAND PHD PETER WHINCUP FFPHM PHD MSC MB BCHIR NITA G. FOROUHI MFPH PHD MSC MRCP MB BS BMEDSCI E p i d e m i o l o g y / H e a l t h

The effects of vitamin D2 or D3 supplementation on glycaemic control and related metabolic parameters in people at risk of type 2 diabetes: protocol of a randomised double-blind placebo-controlled trial

Background The global prevalence of type 2 diabetes is increasing. Effective strategies to address this public health challenge are currently lacking. A number of epidemiological studies have reported associations between low concentrations of 25-hydroxy vitamin D and the incidence of diabetes, but a causal link has not been established. We investigate the effect of vitamin D...