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Microdialysis and ultrasound elastography for monitoring of localized muscular reaction after pharmacological stimulation in rats

ObjectiveHalothane and caffeine are known to cause skeletal muscular contractions in vitro and have been proven to induce circumscribed metabolic reactions when injected into rat skeletal muscle. In this study 26 rats were investigated by either continuous application of calcium 160 mM or bolus injection of caffeine 160 mM or halothane 10% vol via a microdialysis probe in the...

Preventing nausea and vomiting in women undergoing regional anesthesia for cesarean section: challenges and solutions

Preventing nausea and vomiting in women undergoing regional anesthesia for cesarean section: challenges and solutions Yvonne Jelting,1 Christian Klein,1 Thomas Harlander,1 Leopold Eberhart,2 Norbert

Monitoring of in-hospital cardiac arrest events with the focus on Automated External Defibrillators – a retrospective observational study

Background Patients with cardiac arrest have lower survival rates, when resuscitation performance is low. In In-hospital settings the first responders on scene are usually nursing staff without rhythm analysing skills. In such cases Automated External Defibrillators (AED) might help guiding resuscitation performance. At the Wuerzburg University Hospital (Germany) an AED-program...

“Colloid twice daily” is not fluid resuscitation! Inappropriate inclusion of clinical trials in meta-analyses may distract from gaps in evidence

Dear Editor, We read with interest the recent systematic review investigating the impact of hydroxyethyl starch administration as part of initial fluid resuscitation for severe sepsis on mortality [1]. The authors claimed to have identified “prospective randomised controlled trials (RCTs) in adult patients with severe sepsis receiving 6 % tetrastarch (of potato or waxy maize...

Management of malignant hyperthermia: diagnosis and treatment

Management of malignant hyperthermia: diagnosis and treatment Daniel Schneiderbanger, Stephan Johannsen, Norbert Roewer, Frank SchusterDepartment of Anaesthesia and Critical Care, University of

Three-dimensional quantitative structure–activity relationship and docking studies in a series of anthocyanin derivatives as cytochrome P450 3A4 inhibitors

Three-dimensional quantitative structure–activity relationship and docking studies in a series of anthocyanin derivatives as cytochrome P450 3A4 inhibitors Sergey Shityakov,1 István Puskás,2 Norbert

Evaluation of suspected malignant hyperthermia events during anesthesia

Background Malignant hyperthermia (MH), a metabolic myopathy triggered by volatile anesthetics and depolarizing muscle relaxants, is a potentially lethal complication of general anesthesia in susceptible patients. The implementation of modern inhalation anesthetics that research indicates as less potent trigger substances and the recommended limitations of succinylcholine use...

Balanced Hydroxyethylstarch (HES 130/0.4) Impairs Kidney Function In-Vivo without Inflammation

Volume therapy is a standard procedure in daily perioperative care, and there is an ongoing discussion about the benefits of colloid resuscitation with hydroxyethylstarch (HES). In sepsis HES should be avoided due to a higher risk for acute kidney injury (AKI). Results of the usage of HES in patients without sepsis are controversial. Therefore we conducted an animal study to...

The effect of succinylcholine on malignant hyperthermia events in susceptible swine

Background While the impact of volatile anaesthetics to induce malignant hyperthermia (MH) is abundantly clear, the role of succinylcholine still remains controversial. To evaluate the influence of succinylcholine on porcine MH events, the authors investigated the hemodynamic and metabolic responses in MH susceptible (MHS) and non-susceptible (MHN) swine following either...

Use of local anaesthetics and adjuncts for spinal and epidural anaesthesia and analgesia at German and Austrian University Hospitals: an online survey to assess current standard practice

Background The present anonymous multicenter online survey was conducted to evaluate the application of regional anaesthesia techniques as well as the used local anaesthetics and adjuncts at German and Austrian university hospitals. Methods 39 university hospitals were requested to fill in an online questionnaire, to determine the kind of regional anaesthesia and preferred drugs...

Aromatase Inhibition Attenuates Desflurane-Induced Preconditioning against Acute Myocardial Infarction in Male Mouse Heart In Vivo

The volatile anesthetic desflurane (DES) effectively reduces cardiac infarct size following experimental ischemia/reperfusion injury in the mouse heart. We hypothesized that endogenous estrogens play a role as mediators of desflurane-induced preconditioning against myocardial infarction. In this study, we tested the hypothesis that desflurane effects local estrogen synthesis by...

The Connection of Monocytes and Reactive Oxygen Species in Pain

The interplay of specific leukocyte subpopulations, resident cells and proalgesic mediators results in pain in inflammation. Proalgesic mediators like reactive oxygen species (ROS) and downstream products elicit pain by stimulation of transient receptor potential (TRP) channels. The contribution of leukocyte subpopulations however is less clear. Local injection of neutrophilic...

Effects of crystalloids and colloids on liver and intestine microcirculation and function in cecal ligation and puncture induced septic rodents

Background Septic acute liver and intestinal failure is associated with a high mortality. We therefore investigated the influence of volume resuscitation with different crystalloid or colloid solutions on liver and intestine injury and microcirculation in septic rodents. Methods Sepsis was induced by cecal ligation and puncture (CLP) in 77 male rats. Animals were treated with...

Delayed systemic air embolism in a child with severe blunt chest trauma treated with high-frequency oscillatory ventilation

Purpose Trauma is the leading cause of death in children over one year of age. Even with optimal field care, blunt chest trauma with hemoptysis is a potentially fatal injury due to exsanguination or arterial air embolism. Most often, cardiovascular collapse that is unresponsive to therapy develops shortly after endotracheal intubation and initiation of positive pressure...

High frequency oscillatory ventilation and prone positioning in a porcine model of lavage-induced acute lung injury

Greim 0 Norbert Roewer - 1 0 Klinik fur Anasthesiologie , Intensiv- und Notfallmedizin, Klinikum Fulda, Pacelliallee 4, 36043 Fulda , Germany 1 Klinik und Poliklinik fur Anasthesiologie