Author Contributions Conceptualization: Suleiman Alhaji Muhammad, Noor Hayaty Abu Kasim, Sharida Fakurazi. Formal analysis: Suleiman Alhaji Muhammad, Norshariza Nordin, Muhammad Zulfadli Mehat, Sharida ... Fakurazi. Funding acquisition: Suleiman Alhaji Muhammad, Norshariza Nordin, Paisal Hussin, Sharida Fakurazi. Investigation: Suleiman Alhaji Muhammad, Paisal Hussin. Writing – original draft: Suleiman
. Investigation: Hadri Hadi bin Md Yusof, Norshariza Nordin, Yoke Kqueen Cheah, Eric Tatt Wei Ho, King-Hwa Ling, Pike-See Cheah. Methodology: Eryse Amira Seth, Han-Chung Lee, Hadri Hadi bin Md Yusof, Norshariza ... . Writing – original draft: Eryse Amira Seth, Han-Chung Lee, Hadri Hadi bin Md Yusof, Norshariza Nordin, Yoke Kqueen Cheah, Eric Tatt Wei Ho, King-Hwa Ling, Pike-See Cheah. Writing – review & editing: King
One of the strategies in the establishment of in vitro oxidative stress models for neurodegenerative diseases, such as Alzheimer’s disease (AD), is to induce neurotoxicity by amyloid beta (Aβ) peptides in suitable neural cells. Presently, data on the neurotoxicity of Aβ in neural cells differentiated from stem cells are limited. In this study, we attempted to induce oxidative...
Jaafaru, Norshariza Nordin, Khozirah Shaari, Rozita Rosli, Ahmad Faizal Abdull Razis. Data curation: Mohammed Sani Jaafaru, Norshariza Nordin, Khozirah Shaari, Rozita Rosli, Ahmad Faizal Abdull Razis ... . Formal analysis: Mohammed Sani Jaafaru, Norshariza Nordin. Funding acquisition: Ahmad Faizal Abdull Razis. Investigation: Mohammed Sani Jaafaru, Khozirah Shaari, Ahmad Faizal Abdull Razis. Methodology
Breast cancer remains a leading cause of death in women worldwide. Although breast cancer therapies have greatly advanced in recent years, many patients still develop tumour recurrence and metastasis, and eventually succumb to the disease due to chemoresistance. Citral has been reported to show cytotoxic effect on various cancer cell lines. However, the potential of citral to...
Breast cancer remains a leading cause of death in women worldwide. Although breast cancer therapies have greatly advanced in recent years, many patients still develop tumour recurrence and metastasis, and eventually succumb to the disease due to chemoresistance. Citral has been reported to show cytotoxic effect on various cancer cell lines. However, the potential of citral to...
Glutamate is the primary excitatory neurotransmitter in the central nervous system. Excessive concentrations of glutamate in the brain can be excitotoxic and cause oxidative stress, which is associated with Alzheimer’s disease. In the present study, the effects of vitamin E in the form of tocotrienol-rich fraction (TRF) and alpha-tocopherol (α-TCP) in modulating the glutamate...
Nordin,1,2 Nur’izzati Mansor,1,2 and Amirah Salwani Zaulkffali3 1Department of Biomedical Science, Faculty of Medicine and Health Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
The receptor for advanced glycation end products (RAGE) is a transmembrane receptor of the immunoglobulin superfamily, capable of binding a broad repertoire of ligands. RAGE-ligands interaction induces a series of signal transduction cascades and lead to the activation of transcription factor NF-B as well as increased expression of cytokines, chemokines, and adhesion molecules...
Direct reprogramming of somatic cells into induced pluripotent stem (iPS) cells has emerged as an invaluable method for generating patient-specific stem cells of any lineage without the use of embryonic materials. Following the first reported generation of iPS cells from murine fibroblasts using retroviral transduction of a defined set of transcription factors, various new...
