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Serum magnesium and risk of incident heart failure in older men: The British Regional Heart Study

To examine the association between serum magnesium and incident heart failure (HF) in older men and investigate potential pathways including cardiac function, inflammation and lung function. Prospective study of 3523 men aged 60–79 years with no prevalent HF or myocardial infarction followed up for a mean period of 15 years, during which 268 incident HF cases were ascertained...

Copeptin and the risk of incident stroke, CHD and cardiovascular mortality in older men with and without diabetes: The British Regional Heart Study

Aims/hypothesis This study aimed to examine the association between copeptin (a surrogate marker of arginine vasopressin) and incident stroke, CHD and cardiovascular mortality in older men with and without diabetes. Methods We conducted a prospective study of 3536 men aged 60–79 years who were followed for an average of 13 years. During this period, there were 437 major CHD...

The relationships between body composition characteristics and cognitive functioning in a population-based sample of older British men

Background Current research has established obesity as one of the main modifiable risk factors for cognitive impairment. However, evidence on the relationships of total and regional body composition measures as well as sarcopenia with cognitive functioning in the older population remains inconsistent. Methods Data are based on 1,570 participants from the British Regional Heart...

Adiposity in Early, Middle and Later Adult Life and Cardiometabolic Risk Markers in Later Life; Findings from the British Regional Heart Study

Objectives: This research investigates the associations between body mass index (BMI) at 21, 40–59, 60–79 years of age on cardiometabolic risk markers at 60–79 years. Methods: A prospective study of 3464 British men with BMI measured at 40–59 and 60–79 years, when cardiometabolic risk was assessed. BMI at 21 years was ascertained from military records, or recalled from middle-age...

Carboxyhaemoglobin levels and their determinants in older British men

Background Although there has been concern about the levels of carbon monoxide exposure, particularly among older people, little is known about COHb levels and their determinants in the general population. We examined these issues in a study of older British men. Methods Cross-sectional study of 4252 men aged 60–79 years selected from one socially representative general practice...

Missed opportunities for secondary prevention of cerebrovascular disease in elderly British men from 1999 to 2005: a population-based study

Objective We examined patterns in medication use for secondary prevention of cerebrovascular disease in older British men from 1999 to 2005, and investigated socio-demographic and disease-related influences on medication use. Methods Percentage use of antiplatelet drugs, blood pressure-lowering drugs and statins use was calculated in men, aged 65–87 years in 2005, who had been...

Secondary prevention of coronary heart disease in older British men: extent of inequalities before and after implementation of the National Service Framework

Administrator 0 Olia Papacosta, Research Statistician 1 Sheena E. Ramsay, Research Fellow 2 Department of Primary Care and Population Sciences, Royal Free and University College Medical School , London , UK 3 The

Fibrinogen and Factor VII Levels Are Related to Adiposity But Not to Fetal Growth or Social Class in Children Aged 10–11 Years

Factors operating in fetal life or during childhood may be important in determining fibrinogen and factor VII concentrations in adult life, and particularly in explaining social gradients in cardiovascular disease risk. In 1994, the authors measured fibrinogen and factor Vile levels in 641 children aged 10–11 years (61% response rate) from schools in five towns in England and...