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Search: authors:"Olivier Destaing"

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αII-Spectrin Regulates Invadosome Stability and Extracellular Matrix Degradation

microscopy platform of the Institut Albert Boniot with the expertise of Olivier Destaing. We thank Dr. Martine Torres for her editorial assistance. Conceived and designed the experiments: AP MCL OD. Performed ... western immunoblotting. II-Spectrin silencing does not change significantly the expression of these integrins. (TIF) Aurlie Ponceau (PhD fellow) performed this work. Marie-Christine Lecomte and Olivier

Essential Function of Dynamin in the Invasive Properties and Actin Architecture of v-Src Induced Podosomes/Invadosomes

The large GTPase dynamin plays a key role in endocytosis but is also localized at numerous actin rich sites. We investigated dynamin functions at podosomes/invadosomes, actin-based cellular adhesion structures implicated in tissue invasion. Podosomes/invadosomes are constituted of long F-actin bundles perpendicular to the substratum (actin cores), connected to randomly arranged F...

Flt3+ macrophage precursors commit sequentially to osteoclasts, dendritic cells and microglia

Background Macrophages, osteoclasts, dendritic cells, and microglia are highly specialized cells that belong to the mononuclear phagocyte system. Functional and phenotypic heterogeneity within the mononuclear phagocyte system may reveal differentiation plasticity of a common progenitor, but developmental pathways leading to such diversity are still unclear. Results Mouse bone...