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Probing Cortical Sites of Antipsychotic Drug Action with in vivo Receptor Imaging

Behavioural Neurology 0953-4180 Probing cortical sites of antipsychotic drug action with in vivo receptor imaging P. Shaw 1 L.S. Pilowsky 0 0 Section of Neurochemical Imaging, Institute of

Large pyroelectric properties at reduced depolarization temperature in A-site nonstoichiometry composition of lead-free 0.94Na x Bi y TiO3–0.06Ba z TiO3 ceramics

Nonstoichiometry lead-free 0.94Na x Bi y TiO3–0.06Ba z TiO3 (N x B y T–0.06B z T) (from x = y = 0.5, z = 1.00 to x = 0.5, y = 0.534, z = 1.02) ceramic compositions were prepared by a conventional solid-state route. XRD shows that the compositions are at a morphotropic phase boundary where rhombohedral and tetragonal phases coexist. The depolarization temperature (T d) can be...

Large pyroelectric properties at reduced depolarization temperature in A-site nonstoichiometry composition of lead-free 0.94Na x Bi y TiO3–0.06Ba z TiO3 ceramics

Nonstoichiometry lead-free 0.94Na x Bi y TiO3–0.06Ba z TiO3 (N x B y T–0.06B z T) (from x = y = 0.5, z = 1.00 to x = 0.5, y = 0.534, z = 1.02) ceramic compositions were prepared by a conventional solid-state route. XRD shows that the compositions are at a morphotropic phase boundary where rhombohedral and tetragonal phases coexist. The depolarization temperature (T d) can be...

The effects of Ba2+ content on depolarization temperature and pyroelectric properties of lead-free 0.94Na0.5Bi0.5TiO3–0.06Ba1+xTiO3 ceramics

Lead-free 0.94Na0.5Bi0.5TiO3–0.06Ba1+xTiO3 (NBT–0.06B1+xT) ceramics (0.0 ≤ x ≤ 0.03) were synthesized by a conventional solid-state reaction process. X-ray diffraction shows that the compositions are at the morphotropic phase boundary where rhombohedral and tetragonal phase coexist. Grain size slightly changes with the increase of Ba2+ content and reaches the minimum at x = 0.02...

Sequence diversity and differential expression of major phenylpropanoid-flavonoid biosynthetic genes among three mango varieties

Background Mango fruits contain a broad spectrum of phenolic compounds which impart potential health benefits; their biosynthesis is catalysed by enzymes in the phenylpropanoid-flavonoid (PF) pathway. The aim of this study was to reveal the variability in genes involved in the PF pathway in three different mango varieties Mangifera indica L., a member of the family Anacardiaceae...

Establishing the UK DNA Bank for motor neuron disease (MND)

In 2003 the Motor Neurone Disease (MND) Association, together with The Wellcome Trust, funded the creation of a national DNA Bank specific for MND. It was anticipated that the DNA Bank would constitute an important resource to researchers worldwide and significantly increase activity in MND genetic research. The DNA Bank houses over 3000 high quality DNA samples, all of which...

DNA hairpins destabilize duplexes primarily by promoting melting rather than by inhibiting hybridization

The effect of secondary structure on DNA duplex formation is poorly understood. Using oxDNA, a nucleotide level coarse-grained model of DNA, we study how hairpins influence the rate and reaction pathways of DNA hybridzation. We compare to experimental systems studied by Gao et al. (1) and find that 3-base pair hairpins reduce the hybridization rate by a factor of 2, and 4-base...

Traction esophageal diverticulum: a rare cause of gastro-intestinal bleeding

Esophageal diverticula are uncommon lesions that are usually classified according to their location (cervical, thoracic, or epiphrenic), or underlying pathogenesis (pulsion or traction), and their morphology (true or false).The majority of esophageal diverticula are acquired lesions that occur predominantly in elderly adults. Pulsion, or false, diverticula are the most commonly...

Modification of intracellular glutathione status does not change the cardiac trapping of 64Cu(ATSM)

Background The trapping mechanisms of the PET hypoxia imaging agent copper(II)-diacetyl-bis(N4-methylthiosemicarbazone) (64Cu(ATSM)) remain unresolved, although its reduction prior to dissociation may be mediated by intracellular thiols. Glutathione (GSH) is the most abundant intracellular thiol, and its redox status changes in cancer cells and ischaemic myocardium (two prime...

Target Localization by Resolving the Time Synchronization Problem in Bistatic Radar Systems Using Space Fast-Time Adaptive Processor

Adaptive Processor D. Madurasinghe 0 A. P. Shaw 0 0 Electronic Warfare and Radar Division, Defence Science and Technology Organisation , P.O. Box 1600, Edinburgh, SA 5111 , Australia The proposed ... diffuse jammer multipath by an airborne adaptive radar , ” IEEE Transactions on Aerospace and Electronic Systems , vol. 31 , no. 2 , pp. 805 - 820 , 1995 . [14] D. Madurasinghe and A. P. Shaw , “ Mainlobe

“ALARA issues arising for safety and security of radiation sources and security screening devices” – Summary and recommendations of the 12th European ALARA network workshop

The 12th European ALARA Network (EAN) workshop on “ALARA issues arising for safety and security of radiation sources and security screening devices” took place in Vienna (Austria) in October 2009. The aim of that workshop was to consider how the implementation of ALARA, in terms of planned and emergency situations, involving worker and public doses, is affected by the...

Isolation, identification and expression analysis of salt-induced genes in Suaeda maritima, a natural halophyte, using PCR-based suppression subtractive hybridization

* and Birendra P Shaw 0 Address: Environmental Biotechnology Laboratory, Institute of Life Sciences , Nalco Square, Bhubaneswar, PIN-751023 , India Background: Despite wealth of information generated on

“ALARA in radioactive waste management” Summary and recommendations of the 11th European ALARA Network Workshop

management of radioactive waste . In: ALARA in radioactive waste management, April 9 - 11 , 2008 , Athens (Greece). Croüail P. , Shaw P. , Drouet F. ( 2007 ) “Experience and new developments in implementing

Mainlobe Jammer Nulling via TSI Finders: A Space Fast-Time Adaptive Processor

multichannel radar signalprocessing algorithms for airborne radar. Andrew P. Shaw received a first-class honours degree in physics from the University of Reading, UK, in 1983, and a Ph.D. degree in 1987. From ... . Shaw 0 0 Electronic Warfare and Radar Divison, Defence Science and Technology Organisation , P.O. Box 1500, Edinburgh, SA 5111 , Australia An algorithm based on a space fast-time adaptive processor is

Parental Age Effects on Cortical Morphology in Offspring

The age at which a parent has a child impacts the child's cognition and risk for mental illness. It appears that this risk is curvilinear, with both age extremes associated with lower intelligence and increased prevalence of some neuropsychiatric disorders. Little is known of the neural mechanisms underpinning this phenomenon. We extracted lobar volumes, surface areas, and...

Quantifying the Burden of Rhodesiense Sleeping Sickness in Urambo District, Tanzania

Background Human African trypanosomiasis is a severely neglected vector-borne disease that is always fatal if untreated. In Tanzania it is highly focalised and of major socio-economic and public health importance in affected communities. Objectives This study aimed to estimate the public health burden of rhodesiense HAT in terms of DALYs and financial costs in a highly disease...

Pneumothorax in a Young Man in Brooklyn, New York

Shia Lin,1 Monica Ghitan,1 Igor Brichkov,2 Jason P. Shaw,2 and Edward K. Chapnick1 1Division of Infectious Diseases, 2Department of Surgery, 3Department of Medicine, and 4Department of Pathology

Long-term follow-up of HCV-infected hematopoietic SCT patients and effects of antiviral therapy

for P Shaw in:Nature Research journals • PubMed • Google ScholarSearch for H Einsele in:Nature Research journals • PubMed • Google Scholar Competing interests The authors declare no conflict of interest

Structural Basis of Chemokine Sequestration by a Tick Chemokine Binding Protein: The Crystal Structure of the Complex between Evasin-1 and CCL3

Background Chemokines are a subset of cytokines responsible for controlling the cellular migration of inflammatory cells through interaction with seven transmembrane G protein-coupled receptors. The blocking of a chemokine-receptor interaction results in a reduced inflammatory response, and represents a possible anti-inflammatory strategy, a strategy that is already employed by...