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Systematic analysis of non-structural protein features for the prediction of PTM function potential by artificial neural networks

Post-translational modifications (PTMs) provide an extensible framework for regulation of protein behavior beyond the diversity represented within the genome alone. While the rate of identification of PTMs has rapidly increased in recent years, our knowledge of PTM functionality encompasses less than 5% of this data. We previously developed SAPH-ire (Structural Analysis of PTM...

A 3D Printed Toolbox for Opto-Mechanical Components

In this article we present the development of a set of opto-mechanical components (a kinematic mount, a translation stage and an integrating sphere) that can be easily built using a 3D printer based on Fused Filament Fabrication (FFF) and parts that can be found in any hardware store. Here we provide a brief description of the 3D models used and some details on the fabrication...

Larval stages of the deep-sea lobster Polycheles typhlops (Decapoda, Polychelida) identified by DNA analysis: morphology, systematic, distribution and ecology

Sophia Agrobiotech (INRA) , 400 Route des Chappes, BP 167, 06903 Sophia Antipolis Cedex , France 1 A. P. Torres (&) E. Blanco Instituto Espan ̃ol de Oceanograf ́ıa, Centre Oceanogra`fic de les Balears ... Mediterranean; DNA barcoding; Crustacea; Vertical distribution - Asvin P. Torres and Ferran Palero have contributed equally to this work. Introduction Mediterranean deep-sea benthos is dominated by fishes and

Novel Pancreatic Cancer Cell Lines Derived from Genetically Engineered Mouse Models of Spontaneous Pancreatic Adenocarcinoma: Applications in Diagnosis and Therapy

Pancreatic cancer (PC) remains one of the most lethal human malignancies with poor prognosis. Despite all advances in preclinical research, there have not been significant translation of novel therapies into the clinics. The development of genetically engineered mouse (GEM) models that produce spontaneous pancreatic adenocarcinoma (PDAC) have increased our understanding of the...

Membrane hyperpolarization during human sperm capacitation

Sperm capacitation is a complex and indispensable physiological process that spermatozoa must undergo in order to acquire fertilization capability. Spermatozoa from several mammalian species, including mice, exhibit a capacitation-associated plasma membrane hyperpolarization, which is necessary for the acrosome reaction to occur. Despite its importance, this hyperpolarization...

Gamma-ray bursts and dark energy–dark matter interaction

In this work, gamma-ray burst (GRB) data are used to place constraints on a putative coupling between dark energy and dark matter. Type Ia supernovae constraints from the Sloan Digital Sky Survey II (SDSS-II) first-year results, the cosmic microwave background radiation shift parameter from Wilkinson Microwave Anisotropy Probe seven year results and the baryon acoustic...

Sexual recombination is a signature of a persisting malaria epidemic in Peru

Background The aim of this study was to consider the impact that multi-clone, complex infections have on a parasite population structure in a low transmission setting. In general, complexity of infection (minimum number of clones within an infection) and the overall population level diversity is expected to be minimal in low transmission settings. Additionally, the parasite...

Prevalence of TPMT and ITPA gene polymorphisms and effect on mercaptopurine dosage in Chilean children with acute lymphoblastic leukemia

Background Mercaptopurine (6-MP) plays a pivotal role in treatment of childhood acute lymphoblastic leukemia (ALL); however, interindividual variability in toxicity of this drug due to genetic polymorphism in 6-MP metabolizing enzymes has been described. We determined the prevalence of the major genetic polymorphisms in 6-MP metabolizing enzymes in Chilean children with ALL...

Coexistence of larvae of tuna species and other fish in the surface mixed layer in the NW Mediterranean

To analyze the potential trophic interactions among tuna larvae and other fish species, we studied the larval fish assemblages inhabiting the surface mixed layer around the Balearic Islands using data from two surveys carried out in summer 2006 and 2008. Despite the high diversity, Thunnus alalunga, Auxis rochei, Cyclothone pygmaea and Ceratoscopelus maderensis clearly dominated...

Discovery of Hα satellite emission in a low state of the SW Sextantis star BB Doradus*

3 M. A. P. Torres 7 8 0 Departamento de Astrof ́ısica, Universidad de La Laguna, La Laguna , E-38203 Santa Cruz de Tenerife , Spain 1 Instituto de Astrof ́ısica de Canarias , V ́ıa La ́ctea s/n, La

Optical spectroscopy of the quiescent counterpart to EXO 0748−676: a black widow scenario?

We present phase-resolved optical spectroscopy of the counterpart to the neutron star (NS) low-mass X-ray binary EXO 0748−676, almost one year after it turned into quiescence. The spectra display prominent Hβ and Hγ and weak Fe ii lines in emission. An average of all the spectra (corrected for the orbital motion) also exhibits a very weak line from Mg i. Tomographic...

A bright off-nuclear X-ray source: a type IIn supernova, a bright ULX or a recoiling supermassive black hole in CXO J122518.6+144545

In this paper we report the discovery of CXO J122518.6+144545, a peculiar X-ray source with a position 3.6 ± 0.2 arcsec off-nuclear from a Sloan Digital Sky Survey Data Release 7 (SDSS DR7) z= 0.0447 galaxy. The 3.6 arcsec offset corresponds to 3.2 kpc at the distance of the galaxy. The 0.3–8 keV X-ray flux of this source is 5 × 10−14 erg cm−2 s−1 and its 0.3–8 keV luminosity is...

Defective Glycogenesis Contributes Toward the Inability to Suppress Hepatic Glucose Production in Response to Hyperglycemia and Hyperinsulinemia in Zucker Diabetic Fatty Rats

Tracy P. Torres Yuka Fujimoto E.P. Donahue Richard L. Printz Karen L. Houseknecht Judith L. Treadway Masakazu Shiota OBJECTIVE-Examine whether normalizing net hepatic glyco- The flux from glucose to

Spatial and seasonal variability in cetacean distribution in the fjords of northern Patagonia, Chile

, NSW 2109 , Australia. R. Hucke- Gaete and J. P. Torres-Florez: Marine Mammal Ecology Laboratory , Centro Ballena Azul, Instituto de Ecolog a y Evolucio n, Universidad Austral de Chile , Casilla 567

The fight for accretion: discovery of intermittent mass transfer in BB Doradus in the low state

Our long-term photometric monitoring of southern nova-like cataclysmic variables with the 1.3-m Small and Moderate Aperture Research Telescope System (SMARTS) telescope found BB Doradus fading from V∼ 14.3 towards a deep low state at V∼ 19.3 in 2008 April. Here we present time-resolved optical spectroscopy of BB Dor in this faint state in 2009. The optical spectrum in quiescence...

Time-resolved spectroscopy of the pulsating CV GW Lib

We present time-resolved optical spectroscopy of the dwarf nova GW Librae during its rare 2007 April superoutburst and compare these with quiescent epochs. The data provide the first opportunity to track the evolution of the principal spectral features. In the early stages of the outburst, the optically thick disc dominates the optical and the line components show clear orbital...

The nature of the X-ray transient MAXI J0556−332

. A. P. Torres 7 0 INAF - Osservatorio Astronomico di Brera , via E. Bianchi 46, 23807 Merate , Italy 1 Departamento de Astrofisica, Universidad de La Laguna, E-38205 La Laguna , Tenerife , Spain 2

Optical spectroscopy of the quiescent counterpart to EXO 0748−676

We present phase resolved optical spectroscopy and X-ray timing of the neutron star X-ray binary EXO 0748−676 after the source returned to quiescence in the autumn of 2008. The X-ray light curve displays eclipses consistent in orbital period, orbital phase and duration with the predictions and measurements before the return to quiescence. Hα and He i emission lines are present in...

Chandra localization and optical/near-infrared follow-up of Galactic X-ray sources

We investigate a sample of 11 Galactic X-ray sources recently discovered with INTEGRAL or RXTE with the goal of identifying their optical and/or near-infrared (NIR) counterpart. For this purpose, new Chandra positions of nine objects are presented together with follow-up observations of all the targets in the optical and NIR. For the four sources IGR J16194−2810, IGR J16479−4514...

Phenolic compounds from Rosemary (Rosmarinus officinalis L.) attenuate oxidative stress and reduce blood cholesterol concentrations in diet-induced hypercholesterolemic rats

Background Phenolic compounds combine antioxidant and hypocholesterolemic activities and, consequently, are expected to prevent or minimize cardiometabolic risk. Methods To evaluate the effect of an aqueous extract (AQ) and non-esterified phenolic fraction (NEPF) from rosemary on oxidative stress in diet-induced hypercholesterolemia, 48 male 4-week old Wistar rats were divided...