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Search: authors:"Pablo Navarro"

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A rapid passage through a two-active-X-chromosome state accompanies the switch of imprinted X-inactivation patterns in mouse trophoblast stem cells

Background In female mice, while the presence of two-active X-chromosomes characterises pluripotency, it is not tolerated in most other cellular contexts. In particular, in the trophoblastic lineage, impairment of paternal X (X P ) inactivation results in placental defects. Results Here, we show that Trophoblast Stem (TS) cells can undergo a complete reversal of imprinted X...

Lineage-specific regulation of imprinted X inactivation in extraembryonic endoderm stem cells

Background Silencing of the paternal X chromosome (Xp), a phenomenon known as imprinted X-chromosome inactivation (I-XCI), characterises, amongst mouse extraembryonic lineages, the primitive endoderm and the extraembryonic endoderm (XEN) stem cells derived from it. Results Using a combination of chromatin immunoprecipitation characterisation of histone modifications and single...

The X-inactivation trans-activator Rnf12 is negatively regulated by pluripotency factors in embryonic stem cells

X-inactivation, the molecular mechanism enabling dosage compensation in mammals, is tightly controlled during mouse early embryogenesis. In the morula, X-inactivation is imprinted with exclusive silencing of the paternally inherited X-chromosome. In contrast, in the post-implantation epiblast, X-inactivation affects randomly either the paternal or the maternal X-chromosome. The...

A role for non-coding Tsix transcription in partitioning chromatin domains within the mouse X-inactivation centre

Background Delimiting distinct chromatin domains is essential for temporal and spatial regulation of gene expression. Within the X-inactivation centre region (Xic), the Xist locus, which triggers X-inactivation, is juxtaposed to a large domain of H3K27 trimethylation (H3K27me3). Results We describe here that developmentally regulated transcription of Tsix, a crucial non-coding...

Promoter-restricted H3 Lys 4 di-methylation is an epigenetic mark for monoallelic expression

Claire Rougeulle 0 Pablo Navarro 0 Philip Avner 0 0 Unite de Ge ne tique Mole culaire Murine, Institut Pasteur , 25 rue du Dr Roux, 75015 Paris , France Methylation of histone tails has been

Tumoural denervation of the nigrostriatal pathway

Martin Victor Aaos Teresa Baringo Paola Lievano Leticia De la Cueva Pablo Navarro Estela Arroyo Mario Gonzalez Dolores Abos - A 22-year-old woman, diagnosed 7 years ago with low-grade astrocytoma