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22 papers found.
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Iα to Iβ mechano-conversion and amorphization in native cellulose simulated by crystal bending

The bending of rod-like native cellulose crystals with degree of polymerization 40 and 160 using molecular dynamics simulations resulted in a deformation-induced local amorphization at the kinking point and allomorphic interconversion between cellulose Iα and Iβ in the unbent segments. The transformation mechanism involves a longitudinal chain slippage of the hydrogen-bonded...

On The Lash Bar Count Algorithm Based on Image Recognition

This paper solved the problem that lash bars were difficult to be quickly and accurately counted,and proposed a kind of lash bar count algorithm based on image recognition through observation and study of the morphology of lash bars, namely the algorithm that combines cross type algorithm and flexible T type algorithm. Firstly,the color image is processed by graying and threshold...

Serotonin-Exacerbated DSS-Induced Colitis Is Associated with Increase in MMP-3 and MMP-9 Expression in the Mouse Colon

Background. 5-HT enhances dextran sulfate sodium- (DSS-) induced colitis and is involved in inflammatory bowel disease (IBD). Matrix metalloproteinases (MMPs) play roles in the process of intestinal inflammation. Aims. To examine whether 5-HT induces MMPs expression in mouse colon to enhance DSS-induced colitis. Materials and Methods. C57BL/6J (B6) mice were treated with either...

A Non-sulfided flower-like Ni-PTA Catalyst that Enhances the Hydrotreatment Efficiency of Plant Oil to Produce Green Diesel

performance in the hydrotreatment of Jatropha oil (autoclave was drawn by Pan Chen). Full size image Characterization of flower-like Ni-PTA catalyst The morphology of the catalyst was characterized by ... of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083, P. R. ChinaJing Liu, Pan Chen, Lihong Deng, Jing He, Luying Wang & Jiandu LeiKey Laboratory for Biomechanics and

NiO-PTA supported on ZIF-8 as a highly effective catalyst for hydrocracking of Jatropha oil

, Luying Wang, Rong Li, Pan Chen, Xin Rao, Lihong Deng & Jiandu LeiKey Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang ... for Luying Wang in:Nature Research journals • PubMed • Google ScholarSearch for Rong Li in:Nature Research journals • PubMed • Google ScholarSearch for Pan Chen in:Nature Research journals • PubMed

Short-Fragment DNA Residue from Vaccine Purification Processes Promotes Immune Response to the New Inactivated EV71 Vaccine by Upregulating TLR9 mRNA

To reduce potential oncogenic long genomic DNA in vaccines, nuclease treatment has been applied in the purification processes. However, this action increased the residue of short-fragment DNA and its effect on vaccine potency was still elusive. In this study, we found residual sf-DNA in an inactivated EV71 vaccine could enhance humoral immune response in mice. Ag stimulation in...

Comparing the Primary and Recall Immune Response Induced by a New EV71 Vaccine Using Systems Biology Approaches

Three inactivated EV71 whole-virus vaccines have completed Phase III clinical trials in mainland China, with high efficacy, satisfactory safety, and sustained immunogenicity. However, the molecular mechanisms how this new vaccine elicit potent immune response remain poorly understood. To characterize the primary and recall responses to EV71 vaccines, PBMC from 19 recipients...

Extreme obesity induces massive beta cell expansion in mice through self-renewal and does not alter the beta cell lineage

Aims/hypothesis Understanding the developmental biology of beta cell regeneration is critical for developing new diabetes therapies. Obesity is a potent but poorly understood stimulus for beta cell expansion. Current models of obesity are complicated by developmental compensation or concurrent diabetes, limiting their usefulness for identifying the lineage mechanism(s) of beta...

The Gastric Mucosa from Patients Infected with CagA+ or VacA+ Helicobacter pylori Has a Lower Level of Dual Oxidase-2 Expression than Uninfected or Infected with CagA−/VacA− H. pylori

Background Helicobacter pylori (H. pylori) is a well-recognized gastroduodenal pathogen and class I carcinogen. Dual oxidase-2 (DUOX2), a member of NADPH oxidase family, has several critical physiological functions, including thyroid hormone biosynthesis and host mucosal defense.AimTo investigate the effect of H. pylori infection on DUOX2 gene expression in human stomach...

Lactoferrin suppresses the Epstein–Barr virus-induced inflammatory response by interfering with pattern recognition of TLR2 and TLR9

, Ministry of Education, Changsha, ChinaYing Zheng, Zailong Qin, Qiurong Ye, Pan Chen, Zhaohui Luo, Xiaoping Liu, Yanhong Zhou, Wei Xiong, Jian Ma & Guiyuan LiCenter for Medical Research, Second Xiangya ... • Google ScholarSearch for Zailong Qin in:Nature Research journals • PubMed • Google ScholarSearch for Qiurong Ye in:Nature Research journals • PubMed • Google ScholarSearch for Pan Chen in:Nature Research

TorsinA rescues ER-associated stress and locomotive defects in C. elegans models of ALS

Molecular mechanisms underlying neurodegenerative diseases converge at the interface of pathways impacting cellular stress, protein homeostasis and aging. Targeting the intrinsic capacities of neuroprotective proteins to restore neuronal function and/or attenuate degeneration represents a potential means toward therapeutic intervention. The product of the human DYT1 gene, torsinA...

Complete Genome Analysis of a Haemophilus parasuis Serovar 12 Strain from China

Haemophilus parasuis is the etiological agent of Glässer's disease in pigs and 15 standard serovars were identified. The widespread disease causes great economic loss in the swine industry worldwide. Aiming to investigate the differences in genome composition and functions among various strains, a highly virulent strain ZJ0906 of H. parasuis serovar 12 from China was analyzed and...

Development and Evaluation of a Pseudovirus-Luciferase Assay for Rapid and Quantitative Detection of Neutralizing Antibodies against Enterovirus 71

The level of neutralizing antibodies (NtAb) induced by vaccine inoculation is an important endpoint to evaluate the efficacy of EV71 vaccine. In order to evaluate the efficacy of EV71 vaccine, here, we reported the development of a novel pseudovirus system expression firefly luciferase (PVLA) for the quantitative measurement of NtAb. We first evaluated and validated the...

SPLUNC1 Regulates Cell Progression and Apoptosis through the miR-141-PTEN/p27 Pathway, but Is Hindered by LMP1

Chen Xiaofang Guo Houde Zhou Wenling Zhang Zhaoyang Zeng Qianjin Liao Xiayu Li Bo Xiang Jianbo Yang Jian Ma Ming Zhou Shuping Peng Juanjuan Xiang Xiaoling Li Colvin Wanshura LE Wei Xiong James B

Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

Human hepatitis B virus (HBV) infection and HBV-related diseases remain a major public health problem. Individuals coinfected with its satellite hepatitis D virus (HDV) have more severe disease. Cellular entry of both viruses is mediated by HBV envelope proteins. The pre-S1 domain of the large envelope protein is a key determinant for receptor(s) binding. However, the identity of...

Promoter Hypermethylation-mediated Inactivation of LRRC4 in Gliomas

Background Leucine-rich repeat C4 protein (LRRC4) is a new member of the leucine-rich repeat (LRR) superfamily. It is not only a brain-specific gene but also a novel candidate for tumor suppression. LRRC4 inactivation is commonly found in glioma cell lines and primary glioma biopsies. However, little is known about the mechanism controlling LRRC4 expression. In a previous study...

Extremes of Clinical and Enzymatic Phenotypes in Children With Hyperinsulinism Caused by Glucokinase Activating Mutations

Samir Sayed David R. Langdon Stella Odili Pan Chen Carol Buettger Alisa B. Schiffman Mariko Suchi Rebecca Taub Joseph Grimsby Franz M. Matschinsky Charles A. Stanley OBJECTIVEHeterozygous

The early-onset torsion dystonia-associated protein, torsinA, is a homeostatic regulator of endoplasmic reticulum stress response

Early-onset torsion dystonia is the most severe heritable form of dystonia, a human movement disorder that typically starts during a developmental window in early adolescence. Deletion in the DYT1 gene, encoding the torsinA protein, is responsible for this dominantly inherited disorder, which is non-degenerative and exhibits reduced penetrance among carriers. Here, we explore the...