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From John Snow to omics: the long journey of environmental epidemiology

for Genomic Medicine , Turin , Italy 1 & Paolo Vineis A major difference between infectious and non-communicable diseases is that infectious diseases typically have unique necessary causes whereas

Allostatic load and subsequent all-cause mortality: which biological markers drive the relationship? Findings from a UK birth cohort

The concept of allostatic load (AL) refers to the idea of a global physiological ‘wear and tear’ resulting from the adaptation to the environment through the stress response systems over the life span. The link between socioeconomic position (SEP) and mortality has now been established, and there is evidence that AL may capture the link between SEP and mortality. In order to...

Causality in cancer research: a journey through models in molecular epidemiology and their philosophical interpretation

-210176796] to Paolo Vineis, and partially supported by the Arts and Humanities Research Council via grant AH/M005917/1 to Phyllis Illari and Federica Russo. The authors thank Christopher Wild for comments on

Socioeconomic indicators in epidemiologic research: A practical example from the LIFEPATH study

. Requests should be sent to the PI of the LIFEPATH Project, Paolo Vineis (e-mail . uk). Funding: This study is supported by the European Commission (Horizon 2020 grant nÊ 633666) and Background Several ... , Ragusa, Italy), Paolo Vineis (MRC-PHE Centre for Environment and Health, School of Public Health, Department of Epidemiology and Biostatistics, Imperial College London, London UK), Peter Vollenweider

Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases

. S. Kleinjans 1 Paolo Vineis 4 Soterios A. Kyrtopoulos 2 0 Department of Biobank Research, and Occupational and Environmental Medicine, Department of Public Health and Clinical Medicine, Umeå

Modifiable causes of premature death in middle-age in Western Europe: results from the EPIC cohort study

Background Life expectancy is increasing in Europe, yet a substantial proportion of adults still die prematurely before the age of 70 years. We sought to estimate the joint and relative contributions of tobacco smoking, hypertension, obesity, physical inactivity, alcohol and poor diet towards risk of premature death. Methods We analysed data from 264,906 European adults from the...

A life course approach to explore the biological embedding of socioeconomic position and social mobility through circulating inflammatory markers

and Biostatistics, School of Public Health, Imperial College London, London, UKRaphaële Castagné, Gianluca Campanella, Florence Guida, Roel Vermeulen, Paolo Vineis & Marc Chadeau-HyamINSERM, UMR1027 ... journals • PubMed • Google ScholarSearch for Roel Vermeulen in:Nature Research journals • PubMed • Google ScholarSearch for Paolo Vineis in:Nature Research journals • PubMed • Google ScholarSearch for Silvia

Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation

in:Nature Research journals • PubMed • Google ScholarSearch for Dimitrios Trichopoulos in:Nature Research journals • PubMed • Google ScholarSearch for Paolo Vineis in:Nature Research journals • PubMed

Physical activity and risk of Amyotrophic Lateral Sclerosis in a prospective cohort study

European Community (5th Framework Programme) to Prof. Paolo Vineis (Grant QLK4CT199900927); and a grant of the Compagnia di San Paolo to the ISI Foundation. All authors are independent form founders ... , Paolo Vineis. Analysis and interpretation of data: Valentina Gallo, Nicola Vanacore, H. Bas Bueno-de-Mesquita, Roel Vermeulen, Carol Brayne, Petra A. Wark, Heather A Ward, Pietro Ferrari, Mazda Jenab

Omics for prediction of environmental health effects: Blood leukocyte-based cross-omic profiling reliably predicts diseases associated with tobacco smoking

London, St Mary’s Campus, Norfolk Place, W2 1PG, UKMarc Chadeau-Hyam, Paolo Vineis, Rachel Kelly & Toby J. AthersuchDivision of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht ... • Google ScholarSearch for Paolo Vineis in:Nature Research journals • PubMed • Google ScholarSearch for Soterios A. Kyrtopoulos in:Nature Research journals • PubMed • Google Scholar Contributions S.A.K

Gene-specific DNA methylation profiles and LINE-1 hypomethylation are associated with myocardial infarction risk

Background DNA methylation profiles are responsive to environmental stimuli and metabolic shifts. This makes DNA methylation a potential biomarker of environmental-related and lifestyle-driven diseases of adulthood. Therefore, we investigated if white blood cells’ (WBCs) DNA methylation profiles are associated with myocardial infarction (MI) occurrence. Whole-genome DNA...

Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis

Flower 1 Ed Curry 1 Nicholas Orr Katarzyna Tomczyk Michael E. Jones Alan Ashworth Anthony Swerdlow Marc Chadeau-Hyam 4 Eiliv Lund Montserrat Garcia-Closas Torkjel M. Sandanger James M. Flanagan 0 1 Paolo ... Vineis 0 3 4 0 Equal contributors 1 Epigenetics Unit, Division of Cancer, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London , 4th Floor IRDB, Hammersmith Campus, Du Cane Road

Long-Term Realism and Cost-Effectiveness: Primary Prevention in Combatting Cancer and Associated Inequalities Worldwide

The global figure of 14 million new cancer cases in 2012 is projected to rise to almost 22 million by 2030, with the burden in low- and middle-income countries (LMICs) shifting from 59% to 65% of all cancer cases worldwide over this time. While the overheads of cancer care are set to rapidly increase in all countries worldwide irrespective of income, the limited resources to...

Characterization of whole-genome autosomal differences of DNA methylation between men and women

ShemT‑ov Simone Wahl 0 Harald Grallert 0 Giovanni Fiorito SoY‑oun Shin Katharina Schramm Petra Wolf Sonja Kunze 0 Yael Baran Simonetta Guarrera Paolo Vineis Vittorio Krogh Salvatore Panico Rosario Tumino

Differentially methylated microRNAs in prediagnostic samples of subjects who developed breast cancer in the European Prospective Investigation into Nutrition and Cancer (EPIC-Italy) cohort

The crosstalk between microRNAs (miRNAs) and other epigenetic factors may lead to novel hypotheses about carcinogenesis identifying new targets for research. Because a single miRNA can regulate multiple downstream target genes, its altered expression may potentially be a sensitive biomarker to detect early malignant transformation and improve diagnosis and prognosis. In the...

Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort

Heiner Boeing Pagona Lagiou Christina Bamia Dimitrios Trichopoulos Domenico Palli Valeria Pala Salvatore Panico Rosario Tumino Paolo Vineis H. Bas Bueno-de-Mesquita Petra H. Peeters Elisabete Weiderpass

Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study

¨hn Verena A Katze Heiner Boeing Antonia Trichopoulou Christos Tsironis Pagona Lagiou Domenico Palli Valeria Pala Salvatore Panico Rosario Tumino Paolo Vineis Bueno-de-Mesquita Petra H Peeters Anette

Reliability of Serum Metabolites over a Two-Year Period: A Targeted Metabolomic Approach in Fasting and Non-Fasting Samples from EPIC

Objective Although metabolic profiles have been associated with chronic disease risk, lack of temporal stability of metabolite levels could limit their use in epidemiological investigations. The present study aims to evaluate the reliability over a two-year period of 158 metabolites and compare reliability over time in fasting and non-fasting serum samples. Methods Metabolites...