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From John Snow to omics: the long journey of environmental epidemiology

for Genomic Medicine , Turin , Italy 1 & Paolo Vineis A major difference between infectious and non-communicable diseases is that infectious diseases typically have unique necessary causes whereas

Allostatic load and subsequent all-cause mortality: which biological markers drive the relationship? Findings from a UK birth cohort

The concept of allostatic load (AL) refers to the idea of a global physiological ‘wear and tear’ resulting from the adaptation to the environment through the stress response systems over the life span. The link between socioeconomic position (SEP) and mortality has now been established, and there is evidence that AL may capture the link between SEP and mortality. In order to...

Causality in cancer research: a journey through models in molecular epidemiology and their philosophical interpretation

-210176796] to Paolo Vineis, and partially supported by the Arts and Humanities Research Council via grant AH/M005917/1 to Phyllis Illari and Federica Russo. The authors thank Christopher Wild for comments on

Socioeconomic indicators in epidemiologic research: A practical example from the LIFEPATH study

. Requests should be sent to the PI of the LIFEPATH Project, Paolo Vineis (e-mail . uk). Funding: This study is supported by the European Commission (Horizon 2020 grant nÊ 633666) and Background Several ... , Ragusa, Italy), Paolo Vineis (MRC-PHE Centre for Environment and Health, School of Public Health, Department of Epidemiology and Biostatistics, Imperial College London, London UK), Peter Vollenweider

Modifiable causes of premature death in middle-age in Western Europe: results from the EPIC cohort study

Background Life expectancy is increasing in Europe, yet a substantial proportion of adults still die prematurely before the age of 70 years. We sought to estimate the joint and relative contributions of tobacco smoking, hypertension, obesity, physical inactivity, alcohol and poor diet towards risk of premature death. Methods We analysed data from 264,906 European adults from the...

Physical activity and risk of Amyotrophic Lateral Sclerosis in a prospective cohort study

European Community (5th Framework Programme) to Prof. Paolo Vineis (Grant QLK4CT199900927); and a grant of the Compagnia di San Paolo to the ISI Foundation. All authors are independent form founders ... , Paolo Vineis. Analysis and interpretation of data: Valentina Gallo, Nicola Vanacore, H. Bas Bueno-de-Mesquita, Roel Vermeulen, Carol Brayne, Petra A. Wark, Heather A Ward, Pietro Ferrari, Mazda Jenab

Long-Term Realism and Cost-Effectiveness: Primary Prevention in Combatting Cancer and Associated Inequalities Worldwide

The global figure of 14 million new cancer cases in 2012 is projected to rise to almost 22 million by 2030, with the burden in low- and middle-income countries (LMICs) shifting from 59% to 65% of all cancer cases worldwide over this time. While the overheads of cancer care are set to rapidly increase in all countries worldwide irrespective of income, the limited resources to...

Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis

Flower 1 Ed Curry 1 Nicholas Orr Katarzyna Tomczyk Michael E. Jones Alan Ashworth Anthony Swerdlow Marc Chadeau-Hyam 4 Eiliv Lund Montserrat Garcia-Closas Torkjel M. Sandanger James M. Flanagan 0 1 Paolo ... Vineis 0 3 4 0 Equal contributors 1 Epigenetics Unit, Division of Cancer, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London , 4th Floor IRDB, Hammersmith Campus, Du Cane Road

Gene-specific DNA methylation profiles and LINE-1 hypomethylation are associated with myocardial infarction risk

Background DNA methylation profiles are responsive to environmental stimuli and metabolic shifts. This makes DNA methylation a potential biomarker of environmental-related and lifestyle-driven diseases of adulthood. Therefore, we investigated if white blood cells’ (WBCs) DNA methylation profiles are associated with myocardial infarction (MI) occurrence. Whole-genome DNA...

Characterization of whole-genome autosomal differences of DNA methylation between men and women

ShemT‑ov Simone Wahl 0 Harald Grallert 0 Giovanni Fiorito SoY‑oun Shin Katharina Schramm Petra Wolf Sonja Kunze 0 Yael Baran Simonetta Guarrera Paolo Vineis Vittorio Krogh Salvatore Panico Rosario Tumino

Differentially methylated microRNAs in prediagnostic samples of subjects who developed breast cancer in the European Prospective Investigation into Nutrition and Cancer (EPIC-Italy) cohort

The crosstalk between microRNAs (miRNAs) and other epigenetic factors may lead to novel hypotheses about carcinogenesis identifying new targets for research. Because a single miRNA can regulate multiple downstream target genes, its altered expression may potentially be a sensitive biomarker to detect early malignant transformation and improve diagnosis and prognosis. In the...

Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort

Heiner Boeing Pagona Lagiou Christina Bamia Dimitrios Trichopoulos Domenico Palli Valeria Pala Salvatore Panico Rosario Tumino Paolo Vineis H. Bas Bueno-de-Mesquita Petra H. Peeters Elisabete Weiderpass

Reliability of Serum Metabolites over a Two-Year Period: A Targeted Metabolomic Approach in Fasting and Non-Fasting Samples from EPIC

Objective Although metabolic profiles have been associated with chronic disease risk, lack of temporal stability of metabolite levels could limit their use in epidemiological investigations. The present study aims to evaluate the reliability over a two-year period of 158 metabolites and compare reliability over time in fasting and non-fasting serum samples. Methods Metabolites...

Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: a cohort study

Genevieve Buckland Mara Jos Snchez Miren Dorronsoro Carmen Navarro Aurelio Barricarte Timothy J Key Antonia Trichopoulou Christos Tsironis Pagona Lagiou Giovanna Masala Valeria Pala Rosario Tumino Paolo ... Vineis 1 Salvatore Panico H Bas Bueno-de-Mesquita 1 Peter D Siersema Bodil Ohlsson Karin Jirstrm Maria Wennberg Lena M Nilsson Elisabete Weiderpass Tilman Khn Verena Katzke Kay-Tee Khaw Nick J Wareham Anne

Espresso Coffee Consumption and Risk of Coronary Heart Disease in a Large Italian Cohort

Background The relationship between coffee consumption and coronary heart disease (CHD) has been investigated in several studies with discrepant results. We examined the association between Italian-style (espresso and mocha) coffee consumption and CHD risk. Methods We investigated 12,800 men and 30,449 women without history of cardiovascular disease recruited to the EPICOR...

Dynamics of smoking-induced genome-wide methylation changes with time since smoking cessation

Several studies have recently identified strong epigenetic signals related to tobacco smoking. However, an aspect that did not receive much attention is the evolution of epigenetic changes with time since smoking cessation. We conducted a series of epigenome-wide association studies to capture the dynamics of smoking-induced epigenetic changes after smoking cessation, using...

Plasma Elaidic Acid Level as Biomarker of Industrial Trans Fatty Acids and Risk of Weight Change: Report from the EPIC Study

Background Few epidemiological studies have examined the association between dietary trans fatty acids and weight gain, and the evidence remains inconsistent. The main objective of the study was to investigate the prospective association between biomarker of industrial trans fatty acids and change in weight within the large study European Prospective Investigation into Cancer and...

Circulating Biomarkers of One-Carbon Metabolism in Relation to Renal Cell Carcinoma Incidence and Survival

Background The etiology of renal cell carcinoma (RCC) is only partially understood, but a metabolic component appears likely. We investigated biomarkers of one-carbon metabolism and RCC onset and survival.

Prediagnostic immunoglobulin E levels and risk of chronic lymphocytic leukemia, other lymphomas and multiple myeloma-results of the European Prospective Investigation into Cancer and Nutrition

 Sánchez Soledad Sánchez Signe Borgquist Salma Butt Beatrice Melin Florentin Späth Sabina Rinaldi Paul Brennan Rachel S.Kelly Elio Riboli Paolo Vineis Rudolf Kaaks © The Author 2014. Published by Oxford