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Serum Sex Steroids in Premenopausal Women and Breast Cancer Risk Within the European Prospective Investigation into Cancer and Nutrition (EPIC)

Background: Contrasting etiologic hypotheses about the role of endogenous sex steroids in breast cancer development among premenopausal women implicate ovarian androgen excess and progesterone deficiency, estrogen excess, estrogen and progesterone excess, and both an excess or lack of adrenal androgens (dehydroepiandrosterone [DHEA] or its sulfate [DHEAS]) as risk factors. We...

Meat, Fish, and Colorectal Cancer Risk: The European Prospective Investigation into Cancer and Nutrition

Background: Current evidence suggests that high red meat intake is associated with increased colorectal cancer risk. High fish intake may be associated with a decreased risk, but the existing evidence is less convincing. Methods: We prospectively followed 478 040 men and women from 10 European countries who were free of cancer at enrollment between 1992 and 1998. Information on...

A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium

Wilbert H. M. Peters Rayjean J. Hung John McLaughlin Lars Vatten Inger Njlstad Gary E. Goodman John K. Field Triantafillos Liloglou Paolo Vineis Francoise Clavel-Chapelon Domenico Palli Rosario Martnez

Body Size and Risk of Colon and Rectal Cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC)

Background: Body weight and body mass index (BMI) are positively related to risk of colon cancer in men, whereas weak or no associations exist in women. This discrepancy may be related to differences in fat distribution between sexes or to the use of hormone replacement therapy (HRT) in women. Methods: We used multivariable adjusted Cox proportional hazards models to examine the...

Pooled Analysis and Meta-analysis of Glutathione S-Transferase M1 and Bladder Cancer: A HuGE Review

Smoking is a known risk factor for bladder cancer. The product of the GSTM1 gene, glutathione S-transferase M1 (GSTM1), is involved in the detoxification of polycyclic aromatic hydrocarbons found in tobacco smoke; a homozygous deletion of this gene in approximately 50% of Caucasians and Asians results in a lack of GSTM1 enzyme activity. Most studies examining the relation between...

Ethanol Intake and Risk of Lung Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Sabine Rohrmann ) Jakob Linseisen Hendriek C. Boshuizen John Whittaker Antonio Agudo Paolo Vineis Paolo Boffetta Majken K. Jensen Anja Olsen Kim Overvad Anne Tjnneland Marie-Christine Boutron-Ruault

Hematopoietic cancer and peptic ulcer: a multicenter case-control study

Paolo Vineis 3 Paolo Crosignani 1 Carlotta Sacerdote 3 Arabella Fontana 0 Giovanna Masala 6 7 Lucia Miligi 6 Oriana Nanni 5 Valerio Ramazzotti 4 Stefania Rodella 9 Emanuele Stagnaro 7 Rosario Tumino

Smoking and Lymphoma Risk in the European Prospective Investigation into Cancer and Nutrition

Lymphomas are one of the few cancers that have been increasing in incidence over the past decades. So far, only a few established risk factors have been identified, including immunosuppression and viral infections. Recent evidence suggests etiologic heterogeneity of different lymphoma subtypes. Smoking may affect risk differently, depending on the lymphoma entity. The European...

European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene

Kvetoslava Koppova Paolo Vineis Silvia Polidoro Simonetta Guarrera Carlotta Sacerdote Angeles Panadero Jose I. Sanz-Velez Manuel Sanchez Gabriel Valdivia Maria D. Garcia-Prats Jan G. Hengstler Silvia Selinski

Polymorphisms in fatty acid metabolism-related genes are associated with colorectal cancer risk

Kay-Tee Khaw Nick Wareham Sophie Morois Marie-Christine Boutron-Ruault Franxcoise Clavel-Chapelon Veronique Chajes Mazda Jenab Paolo Boffetta Paolo Vineis Traci Mouw Teresa Norat Elio Riboli Alexandra

Polymorphisms of genes coding for ghrelin and its receptor in relation to anthropometry, circulating levels of IGF-I and IGFBP-3, and breast cancer risk: a case–control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC)

- Ruault Agnes Fournier Jakob Linseisen Annekatrin Lukanova Heiner Boeing Eva Fisher Antonia Trichopoulou Christina Georgila Dimitrios Trichopoulos Domenico Palli Vittorio Krogh Rosario Tumino Paolo Vineis

Fruit and Vegetable Intake and Overall Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC)

Background It is widely believed that cancer can be prevented by high intake of fruits and vegetables. However, inconsistent results from many studies have not been able to conclusively establish an inverse association between fruit and vegetable intake and overall cancer risk.

A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23

. Grubb III Heiner Boeing Paolo Vineis Franc¸ oise Clavel-Chapelon Domenico Palli Rosario Tumino Vittorio Krogh Salvatore Panico Eric J. Duell Jose´ Ramo´ n Quiro´ s Maria-Jose´ Sanchez Carmen Navarro Eva

Lung cancers attributable to environmental tobacco smoke and air pollution in non-smokers in different European countries: a prospective study

Paolo Vineis Gerard Hoek Michal Krzyzanowski Federica Vigna- Taglianti Fabrizio Veglia Luisa Airoldi airoldi

A Network of Investigator Networks in Human Genome Epidemiology

Julia A. Newton Bishop 8 Thomas R. O'Brien Gloria Petersen 9 Elio Riboli () 6 Daniela Seminara 7 Emanuela Taioli 4 Andre G. Uitterlinden () 5 Paolo Vineis 2 Deborah M. Winn Georgia Salanti 1 Julian P. T

The Role of Smoking and Diet in Explaining Educational Inequalities in Lung Cancer Incidence

Menvielle, Hendriek Boshuizen, Anton E. Kunst , Susanne O. Dalton, Paolo Vineis, Manuela M. Bergmann, Silke Hermann, Pietro Ferrari, Ole Raaschou-Nielsen, Anne Tjønneland, Rudolf Kaaks, Jakob Linseisen, Maria

Serum Vitamin D and Risk of Prostate Cancer in a Case-Control Analysis Nested Within the European Prospective Investigation into Cancer and Nutrition (EPIC)

, Imperial College, London, United Kingdom (Paolo Vineis, Elio Riboli); Division of Epidemiology and Life Sciences, Institute for Scientific Interchange Foundation, Torino, Italy (Paolo Vineis); Molecular and

Blood Pressure and Risk of Renal Cell Carcinoma in the European Prospective Investigation into Cancer and Nutrition

Elevated blood pressure has been implicated as a risk factor for renal cell carcinoma (RCC), but prospective studies were confined to men and did not consider the effect of antihypertensive medication. The authors examined the relation among blood pressure, antihypertensive medication, and RCC in the European Prospective Investigation into Cancer and Nutrition (EPIC). Blood...

Inverse correlation between alcohol consumption and lymphocyte levels of 8-hydroxydeoxyguanosine in humans

In a cross-sectional study of 115 premenopausal non-smoking women, we examined the relationship between lymphocyte levels of 8-hydroxy-2′-deoxyguanosine (8-oxodGuo) and habitual alcohol consumption. The study was conducted in four different regions of Europe, including Potsdam (Germany), Turin (Italy), Malmö (Sweden) and Granada (Spain). Mean 8-oxodGuo levels differed...

XRCC1, XRCC3, XPD gene polymorphisms, smoking and 32P-DNA adducts in a sample of healthy subjects

Paolo Vineis 7 0 Unita` di Epidemiologia , CSPO, 50135, Firenze 1 ISI Foundation, Institute for Scientific Interchange , Villa Gualino, 10133, Torino 2 Dipartimento di Genetica , Biologia e Biochimica ... : Paolo Vineis (P.I), Laura Davico, Laura Fiorini, Maria Luisa Abbadini and Fabrizio Veglia (ISI Foundation). (iii) EPIC-Florence: Unita` di Epidemiologia, CSPO, Firenze. Key personnel: Domenico Palli (P.I