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A Field Synopsis on Low-Penetrance Variants in DNA Repair Genes and Cancer Susceptibility

, University of Ioannina School of Medicine , Ioannina 45110, Greece ( 1 Paolo Vineis, Maurizio Manuguerra, Fotini K. Kavvoura, Simonetta Guarrera, Alessandra Allione, Fabio Rosa, Alessandra Di Gregorio, Silvia

A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium

Wilbert H. M. Peters Rayjean J. Hung John McLaughlin Lars Vatten Inger Njlstad Gary E. Goodman John K. Field Triantafillos Liloglou Paolo Vineis Francoise Clavel-Chapelon Domenico Palli Rosario Martnez

A Network of Investigator Networks in Human Genome Epidemiology

Julia A. Newton Bishop 8 Thomas R. O'Brien Gloria Petersen 9 Elio Riboli () 6 Daniela Seminara 7 Emanuela Taioli 4 Andre G. Uitterlinden () 5 Paolo Vineis 2 Deborah M. Winn Georgia Salanti 1 Julian P. T

A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23

. Grubb III Heiner Boeing Paolo Vineis Franc¸ oise Clavel-Chapelon Domenico Palli Rosario Tumino Vittorio Krogh Salvatore Panico Eric J. Duell Jose´ Ramo´ n Quiro´ s Maria-Jose´ Sanchez Carmen Navarro Eva

Adiposity, hormone replacement therapy use and breast cancer risk by age and hormone receptor status: a large prospective cohort study

Birgit Teucher 0 Heiner Boeing Krasimira Aleksandrova Antonia Trichopoulou Pagona Lagiou Dimitrios Trichopoulos Domenico Palli Sabina Sieri Salvatore Panico Rosario Tumino Paolo Vineis Jos Ramn Quirs

Air pollution and cancer: biomarker studies in human populations†

the open access publication charges for this article was provided by the European Commission (QLK4-CT-1999-00927) to Paolo Vineis. Conflict of Interest Statement: None declared. References

Allostatic load and subsequent all-cause mortality: which biological markers drive the relationship? Findings from a UK birth cohort

The concept of allostatic load (AL) refers to the idea of a global physiological ‘wear and tear’ resulting from the adaptation to the environment through the stress response systems over the life span. The link between socioeconomic position (SEP) and mortality has now been established, and there is evidence that AL may capture the link between SEP and mortality. In order to...

An Absolute Risk Model to Identify Individuals at Elevated Risk for Pancreatic Cancer in the General Population

Den Eeden Paolo Vineis Jarmo Virtamo Jean Wactawski-Wende Brian M. Wolpin Herbert Yu Kai Yu Anne Zeleniuch-Jacquotte Stephen J. Chanock Robert N. Hoover Patricia Hartge Peter Kraft - Purpose: We

Assessing causal relationships in genomics: From Bradford-Hill criteria to complex gene-environment interactions and directed acyclic graphs

European Union 6th Framework Program, Priority 5: “Food Quality and Safety” (Contract No 513943). Paolo Vineis would like to acknowledge the European Union grant HEALTH-2007-201550 HyperGenes. Sara Geneletti

Association Between Genetic Variants on Chromosome 15q25 Locus and Objective Measures of Tobacco Exposure

George R. Uhl Paolo Vineis Sandosh Padmanabhan Barbara J. Jefferis Antoinette Amuzu Elio Riboli Mark N. Upton Paul Aveyard Shah Ebrahim Aroon D. Hingorani Graham Watt Tom M. Palmer Nicholas J. Timpson EPIC

Association Between Total Number of Deaths, Diabetes Mellitus, Incident Cancers, and Haplotypes in Chromosomal Region 8q24 in a Prospective Study

, Silvia Polidoro, Alessandra Allione, Fabio Rosa, Floriana Voglino, Rossana Critelli, Alessia Russo, Paolo Vineis, Giuseppe Matullo); Department of Genetics, Biology, and Biochemistry, University of Torino ... Environment and Health, St. Marys Campus, Imperial College London, London, United Kingdom (Paolo Vineis). This work was supported by grants from the Associazione Italiana per le Ricerche sul Cancro, Italy (to

Autoantibodies to Ezrin are an early sign of pancreatic cancer in humans and in genetically engineered mouse models

4 Alessio Naccarati 6 Carlotta Sacerdote 5 6 Stefania Beghelli 10 Samantha Bersani 9 Stefano Barbi 9 Claudio Bassi 3 Aldo Scarpa 9 10 Paola Nistic 12 Mirella Giovarelli 0 1 4 Paolo Vineis 6 13 Michele

Biomarkers of Oxidative Stress and Risk of Developing Colorectal Cancer: A Cohort-nested Case-Control Study in the European Prospective Investigation Into Cancer and Nutrition

London, London, United Kingdom (Paolo Vineis); HuGeF Foundation, Turin, Italy (Paolo Vineis); Department of Clinical and Experimental Medicine, Faculty of Medicine, Federico II University, Naples, Italy

Biomarkers of dietary intake of micronutrients modulate DNA adduct levels in healthy adults

DNA adducts, a reliable indicator of internal dose exposure to genotoxic agents and, possibly, of cancer risk, have been shown to be modulated by diet, particularly by the consumption of fresh fruit and vegetables, and by the intake of antioxidants (Palli et al., 2000, Int. J. Cancer, 87, 444–451). We have therefore investigated the association between DNA adducts in peripheral...

Birth Order and Risk of Non-Hodgkin Lymphoma—True Association or Bias?

There is inconsistent evidence that increasing birth order may be associated with risk of non-Hodgkin lymphoma (NHL). The authors examined the association between birth order and related variables and NHL risk in a pooled analysis (1983–2005) of 13,535 cases and 16,427 controls from 18 case-control studies within the International Lymphoma Epidemiology Consortium (InterLymph...

Blood Erythrocyte Concentrations of Cadmium and Lead and the Risk of B-Cell Non-Hodgkin’s Lymphoma and Multiple Myeloma: A Nested Case-Control Study

BackgroundCadmium (Cd) and lead (Pb) are hypothesised to be risk factors for non-Hodgkin’s lymphoma (NHL), a group of haematological malignancies with a suspected environmental aetiology. Within the EnviroGenoMarkers study we utilised pre-diagnostic erythrocyte concentrations of Cd and Pb to determine whether exposure was associated with risk of B-cell NHL and multiple myeloma...

Blood Pressure and Risk of Renal Cell Carcinoma in the European Prospective Investigation into Cancer and Nutrition

Elevated blood pressure has been implicated as a risk factor for renal cell carcinoma (RCC), but prospective studies were confined to men and did not consider the effect of antihypertensive medication. The authors examined the relation among blood pressure, antihypertensive medication, and RCC in the European Prospective Investigation into Cancer and Nutrition (EPIC). Blood...

Body Size and Risk of Colon and Rectal Cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC)

Background: Body weight and body mass index (BMI) are positively related to risk of colon cancer in men, whereas weak or no associations exist in women. This discrepancy may be related to differences in fat distribution between sexes or to the use of hormone replacement therapy (HRT) in women. Methods: We used multivariable adjusted Cox proportional hazards models to examine the...

Cancer as an evolutionary process at the cell level: an epidemiological perspective

Germ-line mutations (present in all cells) in genes that are crucial for the cell cycle cause cancer only in specific cell lines (e.g. mismatch repair genes in the colon; BRCA1-2 in breast and ovary; other cancers in Bloom syndrome, neurofibromatosis and xeroderma pigmentosum). The mutation rate of genes other than mismatch repair or p53 is the same in colon cancer and in normal...

Causal diagrams in systems epidemiology

Methods of diagrammatic modelling have been greatly developed in the past two decades. Outside the context of infectious diseases, systematic use of diagrams in epidemiology has been mainly confined to the analysis of a single link: that between a disease outcome and its proximal determinant(s). Transmitted causes ("causes of causes") tend not to be systematically analysed. The...