There is growing interest in examining the simultaneous effects of multiple exposures and, more generally, the effects of mixtures of exposures, as part of the exposome concept (being defined as the totality of human environmental exposures from conception onwards). Uncovering such combined effects is challenging owing to the large number of exposures, several of them being...
Birgit Teucher 0 Heiner Boeing Krasimira Aleksandrova Antonia Trichopoulou Pagona Lagiou Dimitrios Trichopoulos Domenico Palli Sabina Sieri Salvatore Panico Rosario Tumino Paolo Vineis Jos Ramn Quirs
Tumino in:PubMed • Google Scholar Search for Paolo Vineis in:PubMed • Google Scholar Search for José Ramón Quirós in:PubMed • Google Scholar Search for Genevieve Buckland in:PubMed • Google Scholar
European Union 6th Framework Program, Priority 5: “Food Quality and Safety” (Contract No 513943). Paolo Vineis would like to acknowledge the European Union grant HEALTH-2007-201550 HyperGenes. Sara Geneletti
Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Program, Priority 5: "Food Quality and Safety" (Contract No 513943). Paolo Vineis would like to acknowledge
Silvia Polidoro in:PubMed • Google Scholar Search for Manuela Assumma in:PubMed • Google Scholar Search for Laura Baglietto in:PubMed • Google Scholar Search for Paolo Vineis in:PubMed • Google Scholar
Methods of diagrammatic modelling have been greatly developed in the past two decades. Outside the context of infectious diseases, systematic use of diagrams in epidemiology has been mainly confined to the analysis of a single link: that between a disease outcome and its proximal determinant(s). Transmitted causes ("causes of causes") tend not to be systematically analysed. The...
The eruption of genetic research presents a tremendous opportunity to epidemiologists to improve our ability to identify causes of ill health. Epidemiologists have enthusiastically embraced the new tools of genomics and proteomics to investigate gene-environment interactions. We argue that neither the full import nor limitations of such studies can be appreciated without...
The eruption of genetic research presents a tremendous opportunity to epidemiologists to improve our ability to identify causes of ill health. Epidemiologists have enthusiastically embraced the new tools of genomics and proteomics to investigate gene-environment interactions. We argue that neither the full import nor limitations of such studies can be appreciated without...
-210176796] to Paolo Vineis, and partially supported by the Arts and Humanities Research Council via grant AH/M005917/1 to Phyllis Illari and Federica Russo. The authors thank Christopher Wild for comments on
socio- economic and psychological factors. Notes Paolo Vineis, Phyllis Illari and Federica Russo contributed equally to this work Declarations Authors’ contributions All authors equally contributed ... EU H2020 grant [Proposal Number: SEP-210176796] to Paolo Vineis, and partially supported by the Arts and Humanities Research Council via grant AH/M005917/1 to Phyllis Illari and Federica Russo. The
Background It has been documented that variations exist in breast cancer treatment despite wide dissemination of clinical practice guidelines. The aim of this population-based study was to evaluate the impact of regional guidelines (Piedmont guidelines, PGL) for breast cancer diagnosis and treatment on quality-of-care indicators in the Northwestern Italian region of Piedmont...
It has been documented that variations exist in breast cancer treatment despite wide dissemination of clinical practice guidelines. The aim of this population-based study was to evaluate the impact of regional guidelines (Piedmont guidelines, PGL) for breast cancer diagnosis and treatment on quality-of-care indicators in the Northwestern Italian region of Piedmont. We included...
Population disease proportions attributable to various causal agents are popular as they present a simplified view of the contribution of each agent to the disease load. However they are only summary figures that may be easily misinterpreted or over-interpreted even when the causal link between an exposure and an effect is well established. This commentary discusses several...
results -Demonstrate the utility of the exposome approach to funders and policy makers Plenary discussion – Internal Exposome The plenary session on the “Internal Exposome” led by Paolo Vineis and Tim ... . Weak Carcinogens and “Pathway Perturbation” Paolo Vineis in a presentation “Weak carcinogens and “pathway perturbation””, highlighted some of the ways in which EXPOsOMICS research is contributing to
As an introduction to the series of papers arising from the first ‘Lorenzo Tomatis Conference on Environment and Cancer’ , Tomatis’ contributions to research in cancer prevention are first noted, especially the ongoing programme ‘IARC Monographs on Carcinogenic Risk for humans’ that he established at the International Agency for Research on Cancer’ , of which he was the Director...
As an introduction to the series of papers arising from the first ‘Lorenzo Tomatis Conference on Environment and Cancer’ , Tomatis’ contributions to research in cancer prevention are first noted, especially the ongoing programme ‘IARC Monographs on Carcinogenic Risk for humans’ that he established at the International Agency for Research on Cancer’ , of which he was the Director...
BackgroundIt is well established that estrogens and other hormonal factors influence breast cancer susceptibility. We hypothesized that a woman’s total lifetime estrogen exposure accumulates changes in DNA methylation, detectable in the blood, which could be used in risk assessment for breast cancer.MethodsAn estimated lifetime estrogen exposure (ELEE) model was defined using...
It is well established that estrogens and other hormonal factors influence breast cancer susceptibility. We hypothesized that a woman’s total lifetime estrogen exposure accumulates changes in DNA methylation, detectable in the blood, which could be used in risk assessment for breast cancer. An estimated lifetime estrogen exposure (ELEE) model was defined using epidemiological...
Flower 1 Ed Curry 1 Nicholas Orr Katarzyna Tomczyk Michael E. Jones Alan Ashworth Anthony Swerdlow Marc Chadeau-Hyam 4 Eiliv Lund Montserrat Garcia-Closas Torkjel M. Sandanger James M. Flanagan 0 1 Paolo ... Vineis 0 3 4 0 Equal contributors 1 Epigenetics Unit, Division of Cancer, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London , 4th Floor IRDB, Hammersmith Campus, Du Cane Road
