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Search: authors:"Pardini, Barbara"

6 papers found.
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Polymorphisms in microRNA genes as predictors of clinical outcomes in colorectal cancer patients

Colorectal cancer (CRC) is one of the most frequently diagnosed malignancies worldwide. It is routinely cured by a 5-fluorouracil (5-FU)-based chemotherapy which improves outcomes in patients. We investigated the effect of single nucleotide polymorphisms (SNPs) in two microRNA (miRNA)-encoding genes that have been previously reported as important in prognosis in patients with...

Association of DNA repair polymorphisms with DNA repair functional outcomes in healthy human subjects

We investigated association between polymorphisms in DNA repair genes and the capacity to repair DNA damage induced by γ-irradiation and by base oxidation in a healthy population. Irradiation-specific DNA repair rates were significantly decreased in individuals with XRCC1 Arg399Gln homozygous variant genotype (0.45 ± 0.47 SSB/10 9 Da) than in those with wild-type genotype (1.10...

Genome-wide association study for colorectal cancer identifies risk polymorphisms in German familial cases and implicates MAPK signalling pathways in disease susceptibility

Genetic susceptibility accounts for ∼35% of all colorectal cancer (CRC). Ten common low-risk variants contributing to CRC risk have been identified through genome-wide association studies (GWASs). In our GWAS, 610 664 genotyped single-nucleotide polymorphisms (SNPs) passed the quality control filtering in 371 German familial CRC patients and 1263 controls, and replication studies...