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Genetic Research and Women’s Heart Disease: a Primer

Standards Conflict of Interest Maryam Kavousi is supported by the VENI grant (91616079) from The Netherlands Organization for Health Research and Development (ZonMw). Lawrence F. Bielak and Patricia A ... . Peyser declare that they have no conflict of interest. Human and Animal Rights and Informed Consent This article does not contain any studies with human or animal subjects performed by any of the authors

The cis and trans effects of the risk variants of coronary artery disease in the Chr9p21 region

Background Recent genome-wide association studies (GWAS) have shown that single nucleotide polymorphisms (SNPs) in the Chr9p21 region are associated with coronary artery disease (CAD). Most of the SNPs identified in this region are non-coding SNPs, suggesting that they may influence gene expression by cis or trans mechanisms to affect disease susceptibility. Since all cells from...

The relationship between diastolic blood pressure and coronary artery calcification is dependent on single nucleotide polymorphisms on chromosome 9p21.3

Background Single nucleotide polymorphisms (SNPs) within the 9p21.3 genomic region have been consistently associated with coronary heart disease (CHD), myocardial infarction, and quantity of coronary artery calcification (CAC), a marker of subclinical atherosclerosis. Prior studies have established an association between blood pressure measures and CAC. To examine mechanisms by...

Genetic associations with expression for genes implicated in GWAS studies for atherosclerotic cardiovascular disease and blood phenotypes

Genome-wide association studies (GWAS) have uncovered many genetic associations for cardiovascular disease (CVD). However, data are limited regarding causal genetic variants within implicated loci. We sought to identify regulatory variants (cis- and trans-eQTLs) affecting expression levels of 93 genes selected by their proximity to SNPs with significant associations in prior GWAS...

Genome-Wide Association Study of Gene by Smoking Interactions in Coronary Artery Calcification

. Peyser 0 James E. Hixson 0 Dan E. Arking, Johns Hopkins University, United States of America 0 1 Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science

The Association of Coronary Artery Calcification and Carotid Artery Intima-Media Thickness With Distinct, Traditional Coronary Artery Disease Risk Factors in Asymptomatic Adults

Asymptomatic Adults Evadnie Rampersaud Lawrence F. Bielak Afshin Parsa Haiqing Shen Wendy Post Kathleen A. Ryan Patrick Donnelly John A. Rumberger Patrick F. Sheedy II Patricia A. Peyser Alan R. Shuldiner ... , Maryland (Wendy Post); Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan (Lawrence F. Bielak, Patricia A. Peyser); Department of Cardiovascular Diseases, The

Genetics of coronary artery calcification among African Americans, a meta-analysis

Background Coronary heart disease (CHD) is the major cause of death in the United States. Coronary artery calcification (CAC) scores are independent predictors of CHD. African Americans (AA) have higher rates of CHD but are less well-studied in genomic studies. We assembled the largest AA data resource currently available with measured CAC to identify associated genetic variants...

Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes

Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies (GWAS) in individuals of European ancestry. In order to investigate the genetic architecture of T2D in African Americans, the...

Genome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci

Central obesity, measured by waist circumference (WC) or waist-hip ratio (WHR), is a marker of body fat distribution. Although obesity disproportionately affects minority populations, few studies have conducted genome-wide association study (GWAS) of fat distribution among those of predominantly African ancestry (AA). We performed GWAS of WC and WHR, adjusted and unadjusted for...

Potential of Quantity of Coronary Artery Calcification to Identify New Risk Factors for Asymptomatic Atherosclerosis

- tion , Rochester , MN. Reprint requests to Dr. Patricia A. Peyser, Department of Epide- miology, University of Michigan , 109 Observatory, Ann Arbor, Ml 48109 The goals of this study of adults