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Search: authors:"Patrycja Saganowska"

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DSC as a screening tool for rapid co-crystal detection in binary mixtures of benzodiazepines with co-formers

In recent years, co-crystals have been the subject of increasing interest within the pharmaceutical industry because these new solid forms of active pharmaceutical ingredients have the ability to enhance the bioavailability of poorly water-soluble drugs with a low dissolution rate. For this reason, it is crucial to prepare co-crystals of benzodiazepines, i.e. psychoactive drugs ...

Principal component and cluster analyses as supporting tools for co-crystals detection

The application of chemometry as a solution to a range of problems in the pharmaceutical industry has been the subject of increasing interest in recent years. Therefore, the objective of this work was to assess to what extent a chemometric approach based on principal component analysis (PCA) and cluster analysis (CA) can be used as a supplementary tool for co-crystal detection ...