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116 papers found.
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Chronic disease research in Europe and the need for integrated population cohorts

Lyon Cedex 08 , France 2 & Paul Brennan 3 Imperial College London , London , UK 4 Biobanking and Biomolecular Research Resources Infrastructure (BBMRI-ERIC) , Graz , Austria 5 Department of Human

Genomic analysis of head and neck cancer cases from two high incidence regions

FP7 Marie Curie ActionsÐPeopleÐCo-funding of regional, national and international programmes (COFUND). Author Contributions Conceptualization: Paul Brennan. Formal analysis: Sandra Perdomo, Matthieu ... Polesel, Ivana Holcatova, Lorenzo Simonato, Cristina Canova, Pagona Lagiou, James D. McKay. Software: Matthieu Foll. Supervision: Paul Brennan. Writing ± original draft: Sandra Perdomo, Paul Brennan

Gene-set meta-analysis of lung cancer identifies pathway related to systemic lupus erythematosus

Introduction Gene-set analysis (GSA) is an approach using the results of single-marker genome-wide association studies when investigating pathways as a whole with respect to the genetic basis of a disease. Methods We performed a meta-analysis of seven GSAs for lung cancer, applying the method META-GSA. Overall, the information taken from 11,365 cases and 22,505 controls from...

Circulating MicroRNAs as Non-Invasive Biomarkers for Early Detection of Non-Small-Cell Lung Cancer

Background Detection of lung cancer at an early stage by sensitive screening tests could be an important strategy to improving prognosis. Our objective was to identify a panel of circulating microRNAs in plasma that will contribute to early detection of lung cancer. Material and Methods Plasma samples from 100 early stage (I to IIIA) non–small-cell lung cancer (NSCLC) patients...

Circulating Concentrations of Vitamin B6 and Kidney Cancer Prognosis: A Prospective Case-Cohort Study

Prospective cohort studies have found that prediagnostic circulating vitamin B6 is inversely associated with both risk of kidney cancer and kidney cancer prognosis. We investigated whether circulating concentrations of vitamin B6 at kidney cancer diagnosis are associated with risk of death using a case-cohort study of 630 renal cell carcinoma (RCC) patients. Blood was collected...

META-GSA: Combining Findings from Gene-Set Analyses across Several Genome-Wide Association Studies

Introduction Gene-set analysis (GSA) methods are used as complementary approaches to genome-wide association studies (GWASs). The single marker association estimates of a predefined set of genes are either contrasted with those of all remaining genes or with a null non-associated background. To pool the p-values from several GSAs, it is important to take into account the...

Reproductive profiles and risk of breast cancer subtypes: a multi-center case-only study

Previous studies have shown that reproductive factors are differentially associated with breast cancer (BC) risk by subtypes. The aim of this study was to investigate associations between reproductive factors and BC subtypes, and whether these vary by age at diagnosis. We used pooled data on tumor markers (estrogen and progesterone receptor, human epidermal growth factor receptor...

Prediction of breast cancer risk based on common genetic variants in women of East Asian ancestry

Long 0 Manjeet K. Bolla Kyriaki Michailidou Joe Dennis Qin Wang Yu-Tang Gao Ying Zheng Alison M. Dunning Montserrat García-Closas Paul Brennan Shou-Tung Chen Ji-Yeob Choi Mikael Hartman Hidemi Ito

Interplay between REST and nucleolin transcription factors: a key mechanism in the overexpression of genes upon increased phosphorylation

Teeo Tediose Martin Kolev Baalasubramanian Sivasankar Paul Brennan B. Paul Morgan Rossen Donev The authors and publisher wish to replace the anti-NCL panel of Figure 3B with the original image shown

Mortality and cancer in relation to ABO blood group phenotypes in the Golestan Cohort Study

Pourshams Paul Brennan Paolo Boffetta Reza Malekzadeh 1 Sanford M Dawsey 0 Christian C Abnet 0 Ashkan Emadi 0 Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Dr

The Clinical Performance of an Office-Based Risk Scoring System for Fatal Cardiovascular Diseases in North-East of Iran

Background Cardiovascular diseases (CVD) are becoming major causes of death in developing countries. Risk scoring systems for CVD are needed to prioritize allocation of limited resources. Most of these risk score algorithms have been based on a long array of risk factors including blood markers of lipids. However, risk scoring systems that solely use office-based data, not...

Identification of shared risk loci and pathways for bipolar disorder and schizophrenia

Bipolar disorder (BD) is a highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. BD shows substantial clinical and genetic overlap with other psychiatric disorders, in particular schizophrenia (SCZ). The genes underlying this etiological overlap remain largely unknown. A recent SCZ genome wide association study (GWAS) by the...

Obesity, metabolic factors and risk of different histological types of lung cancer: A Mendelian randomization study

Background Assessing the relationship between lung cancer and metabolic conditions is challenging because of the confounding effect of tobacco. Mendelian randomization (MR), or the use of genetic instrumental variables to assess causality, may help to identify the metabolic drivers of lung cancer. Methods and findings We identified genetic instruments for potential metabolic risk...

Genetic Variants in Nicotine Addiction and Alcohol Metabolism Genes, Oral Cancer Risk and the Propensity to Smoke and Drink Alcohol: A Replication Study in India

Background Genetic variants in nicotinic acetylcholine receptor and alcohol metabolism genes have been associated with propensity to smoke tobacco and drink alcohol, respectively, and also implicated in genetic susceptibility to head and neck cancer. In addition to smoking and alcohol, tobacco chewing is an important oral cancer risk factor in India. It is not known if these...

Gene–environment interaction and aetiology of cancer: what does it mean and how can we measure it?

Paul Brennan 0 0 Unit of Environmental Cancer Epidemiology, International Agency for Research on Cancer , 150 cours Albert Thomas, F-69008 Lyon, France One form of defence against cancer

Modifiable causes of premature death in middle-age in Western Europe: results from the EPIC cohort study

that provided them. The use of a random sample of anonymised data from the EPIC study can be requested by contacting Dr Paul Brennan, , who will issue the request to members of the EPIC Steering

Diagnostic Accuracy of Age and Alarm Symptoms for Upper GI Malignancy in Patients with Dyspepsia in a GI Clinic: A 7-Year Cross-Sectional Study

Objectives We investigated whether using demographic characteristics and alarm symptoms can accurately predict cancer in patients with dyspepsia in Iran, where upper GI cancers and H. pylori infection are common. Methods All consecutive patients referred to a tertiary gastroenterology clinic in Tehran, Iran, from 2002 to 2009 were invited to participate in this study. Each...

Common Variation at 1q24.1 (ALDH9A1) Is a Potential Risk Factor for Renal Cancer

So far six susceptibility loci for renal cell carcinoma (RCC) have been discovered by genome-wide association studies (GWAS). To identify additional RCC common risk loci, we performed a meta-analysis of published GWAS (totalling 2,215 cases and 8,566 controls of Western-European background) with imputation using 1000 Genomes Project and UK10K Project data as reference panels and...

Determinants of Gastroesophageal Reflux Disease, Including Hookah Smoking and Opium Use– A Cross-Sectional Analysis of 50,000 Individuals

Background Gastroesophageal reflux disease (GERD) is a common cause of discomfort and morbidity worldwide. However, information on determinants of GERD from large-scale studies in low- to medium-income countries is limited. We investigated the factors associated with different measures of GERD symptoms, including frequency, patient-perceived severity, and onset time. Methods We...