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43 papers found.
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Neuroimaging genomics in psychiatry—a translational approach

Neuroimaging genomics is a relatively new field focused on integrating genomic and imaging data in order to investigate the mechanisms underlying brain phenotypes and neuropsychiatric disorders. While early work in neuroimaging genomics focused on mapping the associations of candidate gene variants with neuroimaging measures in small cohorts, the lack of reproducible results...

Validating the use of intrinsic markers in body feathers to identify inter-individual differences in non-breeding areas of northern fulmars

Field Station , Cromarty IV11 8YJ , UK 3 Paul M. Thompson 4 Present Address: British Antarctic Survey , High Cross, Madingley Road, Cambridge CB3 0ET , UK Many wildlife studies use chemical analyses to

Multi-Shell Hybrid Diffusion Imaging (HYDI) at 7 Tesla in TgF344-AD Transgenic Alzheimer Rats

Diffusion weighted imaging (DWI) is widely used to study microstructural characteristics of the brain. Diffusion tensor imaging (DTI) and high-angular resolution imaging (HARDI) are frequently used in radiology and neuroscience research but can be limited in describing the signal behavior in composite nerve fiber structures. Here, we developed and assessed the benefit of a...

Neuroimaging, nutrition, and iron-related genes

Several dietary factors and their genetic modifiers play a role in neurological disease and affect the human brain. The structural and functional integrity of the living brain can be assessed using neuroimaging, enabling large-scale epidemiological studies to identify factors that help or harm the brain. Iron is one nutritional factor that comes entirely from our diet, and its...

Influence of APOE Genotype on Hippocampal Atrophy over Time - An N=1925 Surface-Based ADNI Study

The apolipoprotein E (APOE) e4 genotype is a powerful risk factor for late-onset Alzheimer’s disease (AD). In the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort, we previously reported significant baseline structural differences in APOE e4 carriers relative to non-carriers, involving the left hippocampus more than the right—a difference more pronounced in e4...

An advanced white matter tract analysis in frontotemporal dementia and early-onset Alzheimer’s disease

California , Marina del Rey, CA , USA 3 Paul M. Thompson 4 Departments of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine , Los Angeles, CA , USA 5 Brain, Behavior, and Aging Research Center, VA

Variation in breeding phenology provides insights into drivers of long-term population change in harbour seals

Subject Areas: ecology 0 Line S. Cordes 0 Paul M. Thompson 0 0 Institute of Biological and Environmental Sciences, University of Aberdeen, Lighthouse Field Station , George Street, Cromarty IV11 8YJ

Thicker Temporal Cortex Associates with a Developmental Trajectory for Psychopathic Traits in Adolescents

Psychopathy is a clinical condition characterized by a failure in normal social interaction and morality. Recent studies have begun to reveal brain structural abnormalities associated with psychopathic tendencies in children. However, little is known about whether variations in brain morphology are linked to the developmental trajectory of psychopathic traits over time. In this...

Ictal Depth EEG and MRI Structural Evidence for Two Different Epileptogenic Networks in Mesial Temporal Lobe Epilepsy

Hypersynchronous (HYP) and low voltage fast (LVF) activity are two separate ictal depth EEG onsets patterns often recorded in presurgical patients with MTLE. Evidence suggests the mechanisms generating HYP and LVF onset seizures are distinct, including differential involvement of hippocampal and extra-hippocampal sites. Yet the extent of extra-hippocampal structural alterations...

Subregional Hippocampal Morphology and Psychiatric Outcome in Adolescents Who Were Born Very Preterm and at Term

Background The hippocampus has been reported to be structurally and functionally altered as a sequel of very preterm birth (<33 weeks gestation), possibly due its vulnerability to hypoxic–ischemic damage in the neonatal period. We examined hippocampal volumes and subregional morphology in very preterm born individuals in mid- and late adolescence and their association with...

Head Motion and Inattention/Hyperactivity Share Common Genetic Influences: Implications for fMRI Studies of ADHD

Head motion (HM) is a well known confound in analyses of functional MRI (fMRI) data. Neuroimaging researchers therefore typically treat HM as a nuisance covariate in their analyses. Even so, it is possible that HM shares a common genetic influence with the trait of interest. Here we investigate the extent to which this relationship is due to shared genetic factors, using HM...

Joint genetic analysis of hippocampal size in mouse and human identifies a novel gene linked to neurodegenerative disease

Derrek P Hibar Thomas E Nichols Sarah E Medland Paul M Thompson Reinmar Hager 0 0 Computational and Evolutionary Biology, Faculty of Life Sciences, University of Manchester , Michael Smith Building, Oxford

Short-term disturbance by a commercial two-dimensional seismic survey does not lead to long-term displacement of harbour porpoises

Paul M. Thompson Kate L. Brookes Isla M. Graham Tim R. Barton Keith Needham Gareth Bradbury Nathan D. Merchant 0 WWT Consulting , Slimbridge, Gloucestershire GL2 7BT , UK 1 Kongsberg Maritime Ltd ... science, ecology Author for correspondence: Paul M. Thompson e-mail: Present address: Marine Scotland Science, Marine Laboratory, Aberdeen AB11 9DB, UK. Electronic supplementary material is available at

Correction: Quantitative Amyloid Imaging in Autosomal Dominant Alzheimer’s Disease: Results from the DIAN Study Group

Friedrichsen Nelly Joseph-Mathurin Qing Wang Russ C. Hornbeck Beau M. Ances Abraham Z. Snyder Lisa A. Cash Robert A. Koeppe William E. Klunk Douglas Galasko Adam M. Brickman Eric McDade John M. Ringman Paul M ... . Thompson Andrew J. Saykin Bernardino Ghetti Reisa A. Sperling Keith A. Johnson Stephen P. Salloway Peter R. Schofield Colin L. Masters Victor L. Villemagne Nick C. Fox Stefan Förster Kewei Chen Eric M

Mismatch Negativity in Recent-Onset and Chronic Schizophrenia: A Current Source Density Analysis

Mismatch negativity (MMN) is a component of the event-related potential elicited by deviant auditory stimuli. It is presumed to index pre-attentive monitoring of changes in the auditory environment. MMN amplitude is smaller in groups of individuals with schizophrenia compared to healthy controls. We compared duration-deviant MMN in 16 recent-onset and 19 chronic schizophrenia...

Quantitative Amyloid Imaging in Autosomal Dominant Alzheimer’s Disease: Results from the DIAN Study Group

Amyloid imaging plays an important role in the research and diagnosis of dementing disorders. Substantial variation in quantitative methods to measure brain amyloid burden exists in the field. The aim of this work is to investigate the impact of methodological variations to the quantification of amyloid burden using data from the Dominantly Inherited Alzheimer’s Network (DIAN...

A Multivariate Surface-Based Analysis of the Putamen in Premature Newborns: Regional Differences within the Ventral Striatum

Many children born preterm exhibit frontal executive dysfunction, behavioral problems including attentional deficit/hyperactivity disorder and attention related learning disabilities. Anomalies in regional specificity of cortico-striato-thalamo-cortical circuits may underlie deficits in these disorders. Nonspecific volumetric deficits of striatal structures have been documented...

Brain mapping as a tool to study neurodegeneration

Alzheimer’s disease (AD) is the most common neurodegenerative disorder for those 65 years or older; it currently affects 4.5 million in the United States and is predicted to rise to 13.2 million by the year 2050. Neuroimaging and brain mapping techniques offer extraordinary power to understand AD, providing spatially detailed information on the extent and trajectory of the...

Temporal and spatial variation in age-specific survival rates of a long-lived mammal, the Hawaiian monk seal

Jason D Baker () Paul M Thompson 0 University of Aberdeen, School of Biological Sciences , Lighthouse Field Station, George Street, Cromarty, Ross-shire IV11 8YJ, UK 1 Pacific Islands Fisheries