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Search: authors:"Pedro Gonçalves"

8 papers found.
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Ergonomic strategies to improve radiographers’ posture during mammography activities

Objectives To identify alternatives for radiographers’ postures while performing mammography that can contribute to reduce the risk of work-related musculoskeletal disorders (WRMSDs). Methods Radiographers’ postures to positioning craniocaudal (CC) and mediolateral oblique (MLO) views were simulated without any intervention for three scenarios: radiographer/patient with similar ...

The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells

Background The family of D cyclins has a fundamental role in cell cycle progression, but its members (D1, D2, D3) are believed to have redundant functions. However, there is some evidence that contradicts the notion of mutual redundancy and therefore this concept is still a matter of debate. Results Our data show that the cyclin D1 is indispensable for normal hematopoiesis. Indeed, ...

Activation of a TRP-like channel and intracellular Ca2+ dynamics during phospholipase-C-mediated cell death

The model organism Neurospora crassa undergoes programmed cell death when exposed to staurosporine. Here, we show that staurosporine causes defined changes in cytosolic free Ca2+ ([Ca2+]c) dynamics and a distinct Ca2+ signature that involves Ca2+ influx from the external medium and internal Ca2+ stores. We investigated the molecular basis of this Ca2+ response by using [Ca2+]c ...

RENAL DENERVATION

Introduction and Aims: Endovascular renal denervation is a catheter-based treatment for resistant hypertension that reduces afferent and efferent renal sympathetic nerve activity. In chronic kidney disease, elevated sympathetic activity has been causally linked to disease progression and cardiovascular sequelae. We hypothesized that renal denervation in dialysis patients would ...

HYPERTENSION: EXPERIMENTAL

Introduction and Aims: Few studies have reported the effect of doxazosin as the third antihypertensive agent on morning blood pressure (BP) in diabetic patients with chronic kidney disease (CKD). We assessed the effects of doxazosin on morning BP in these patients using ambulatory BP monitoring (ABPM) devises equipped with heart rate variability analysis and compared the findings ...

Hypertension - human studies

Introduction and Aims:Stroke remains a major cause of disability and mortality in hemodialysis [HD] patients with studies deriving predominantly from US FMC LA n=6,890; RRI n=5,620]. Overall 2% of the cohort [n=575] experienced stroke events [Table 1; p-values shown if <0.1]. Older age, cerebrovascular comorbidity, higher mean pre-dialysis systolic blood pressure [SBP] and ...

Vascular access

Introduction and Aims:Interventions, both endovascular and surgical, are used to manage hemodialysis (HD) native AV fistulae. We postulated that dialysis facilities that routinely prescribe lower blood flow rates would experience lower FPR. Methods:DOPPS data were used from 3 study phases (2: 2002-04, 3:2005-08, and 4: 2009-11) to determine FPR. Rates were calculated as total ...