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Staphylococcus aureus biofilm elicits the expansion, activation and polarization of myeloid-derived suppressor cells in vivo and in vitro

Peng, Ching-Chuan Hsieh, Mel S. Lee, Pey-Jium Chang. Funding acquisition: Kuo-Ti Peng, Mel S. Lee. Investigation: Kuo-Ti Peng, Ching-Chuan Hsieh, Tsung-Yu Huang, Pei-Chun Chen, Hsin Nung Shih, Mel S ... . Lee. Methodology: Ching-Chuan Hsieh, Tsung-Yu Huang, Mel S. Lee, Pey-Jium Chang. Project administration: Pei-Chun Chen. Resources: Tsung-Yu Huang, Hsin-Nung Shih, Mel S. Lee. Supervision: Mel S. Lee

Comparative effectiveness of angiotensin-converting enzyme inhibitors versus angiotensin II receptor blockers for major renal outcomes in patients with diabetes: A 15-year cohort study

Background Angiotensin converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) are considered to have similar renoprotective effects; so far there has been no consensus about their priorities. This study aimed to compare ACEIs and ARBs for major renal outcomes and survival in a 15-year cohort of adults with diabetes. Methods This study utilized Taiwan’s...

Using antidepressants and the risk of stroke recurrence: report from a national representative cohort study

Background Evidence about the association between antidepressants and the risk of stroke recurrence was scanty. This study evaluated the risk of stroke recurrence according to using antidepressants in patients with stroke from a national representative cohort. Methods This cohort study followed 16770 patients aged > =20 years who had an incident stroke from 2000 to 2009 from the...

Risk of Bleeding and Stroke with Oral Anticoagulation and Antiplatelet Therapy in Patients with Atrial Fibrillation in Taiwan: A Nationwide Cohort Study

Background Data on the use of oral anticoagulation (OAC) and antiplatelet therapy and the risk of bleeding and stroke amongst Asian patients with atrial fibrillation (AF) are limited. We investigated the risks of bleeding and stroke with use of oral anticoagulation (OAC) and antiplatelet therapy as mono- or combination therapy, in patients with AF from a Chinese nationwide cohort...

The Impact of Diabetes Mellitus and Corresponding HbA1c Levels on the Future Risks of Cardiovascular Disease and Mortality: A Representative Cohort Study in Taiwan

Background This study explored the relationship between the glycated hemoglobin (HbA1c) level in patients with or without diabetes mellitus and future risks of cardiovascular disease and death. Methods Based on a national representative cohort, a total of 5277 participants (7% with diabetes) were selected from Taiwan's Triple High Survey in 2002. The comorbidities, medication...

Stem cell transplantation therapy in Parkinson’s disease

Ineffective therapeutic treatments and inadequate repair ability in the central nervous system are disturbing problems for several neurological diseases. Fortunately, the development of clinically applicable populations of stem cells has provided an avenue to overcome the failure of endogenous repair systems and substitute new cells into the damaged brain. However, there are...

Total 25-Hydroxyvitamin D Concentration as a Predictor for All-Cause Death and Cardiovascular Event Risk among Ethnic Chinese Adults: A Cohort Study in a Taiwan Community

Background Evidence of an inverse association between serum 25-hydoroxyvitamin D [25(OH)D] and the risk of all-cause death and cardiovascular disease from prospective studies is inconsistent. We tested the relationship between 25(OH)D and the risk among adult ethnic Chinese in Taiwan. Methods We conducted a community-based cohort study of 1816 participants (age 60.2±10.2 yrs, 45...

Population-Based Cohort Analyses of the Bidirectional Relationship Between Type 2 Diabetes and Depression

OBJECTIVE This study addresses the strength of association for the bidirectional relationship between type 2 diabetes and depression.

Increased risk and related factors of depression among patients with COPD: a population-based cohort study

Background Depression is a common and mostly undertreated problem in patients with chronic diseases. However, population-based studies on the association between chronic obstructive pulmonary disease (COPD) and subsequent depression are limited in Asian populations. This study evaluated the incidence and risk factors of depression for patients with COPD in Taiwan. Methods Using...

DNA-Interactive Properties of Crotamine, a Cell-Penetrating Polypeptide and a Potential Drug Carrier

Crotamine, a 42-residue polypeptide derived from the venom of the South American rattlesnake Crotalus durissus terrificus, has been shown to be a cell-penetrating protein that targets chromosomes, carries plasmid DNA into cells, and shows specificity for actively proliferating cells. Given this potential role as a nucleic acid-delivery vector, we have studied in detail the...

Retinitis Pigmentosa Reduces the Risk of Proliferative Diabetic Retinopathy: A Nationwide Population-Based Cohort Study

Purpose To study the association between retinitis pigmentosa (RP) and the progression of diabetic retinopathy (DR). Methods Using the Longitudinal Health Insurance Database 2000 of Taiwan, we identified individuals with an initial diagnosis for RP during the period of 1997–2008. A non-RP comparison group, 10-fold frequency matched by sex, age, index year and the year of diabetes...

SNP rs10248565 in HDAC9 as a novel genomic aberration biomarker of lung adenocarcinoma in non-smoking women

Background Numerous efforts have been made to elucidate the etiology and improve the treatment of lung cancer, but the overall five-year survival rate is still only 15%. Although cigarette smoking is the primary risk factor for lung cancer, only 7% of female lung cancer patients in Taiwan have a history of smoking. Since cancer results from progressive accumulation of genetic...

Compounds that correct F508del-CFTR trafficking can also correct other protein trafficking diseases: an in vitro study using cell lines

Background Many genetic diseases are due to defects in protein trafficking where the mutant protein is recognized by the quality control systems, retained in the endoplasmic reticulum (ER), and degraded by the proteasome. In many cases, the mutant protein retains function if it can be trafficked to its proper cellular location. We have identified structurally diverse correctors...

Concurrent exposure to a dectin-1 agonist suppresses the Th2 response to epicutaneously introduced antigen in mice

Background Epicutaneous sensitization with protein allergen that induces predominant Th2 responses is an important sensitization route in atopic dermatitis. Fungal components have been shown to modulate Th cell differentiation. However, the effects of fungal components on epicutaneous sensitization are unclear. Results In this study, we showed that co-administration of curdlan, a...

Association between chronic viral hepatitis infection and breast cancer risk: a nationwide population-based case-control study

Background In Taiwan, there is a high incidence of breast cancer and a high prevalence of viral hepatitis. In this case-control study, we used a population-based insurance dataset to evaluate whether breast cancer in women is associated with chronic viral hepatitis infection. Methods From the claims data, we identified 1,958 patients with newly diagnosed breast cancer during the...

Positive Association Between Hepatitis C Infection and Oral Cavity Cancer: A Nationwide Population-Based Cohort Study in Taiwan

Objectives The association between viral hepatitis (B and C) and oral cavity cancer has been widely debated. This nationwide, population-based cohort study assessed the subsequent risk of oral cavity cancer among patients with chronic viral hepatitis infection. Materials and Methods Data were retrieved from insurance claims data of 1,000,000 randomly sampled individuals covered...

Diabetes and risk of subsequent gastric cancer: a population-based cohort study in Taiwan

Background Epidemiological data concerning the association between diabetes and the subsequent development of gastric cancer are controversial. This population-based retrospective cohort study investigated the subsequent risk of gastric cancer for diabetic patients. Methods From claims data of the universal health insurance of Taiwan, we identified 19,625 persons aged ≥20 years...

DCB-3503, a Tylophorine Analog, Inhibits Protein Synthesis through a Novel Mechanism

Background DCB-3503, a tylophorine analog, inhibits the growth of PANC-1 (human pancreatic ductal cancer cell line) and HepG2 (human hepatocellular cancer cell line) tumor xenografts in nude mice. The inhibition of growth leads to cancer cell differentiation instead of cell death. However, the mechanisms of action of tylophorine analogs is unknown. Methodology/Principal Findings...

Fine-Grained Rate Shaping for Video Streaming over Wireless Networks

Video streaming over wireless networks faces challenges of time-varying packet loss rate and fluctuating bandwidth. In this paper, we focus on streaming precoded video that is both source and channel coded. Dynamic rate shaping has been proposed to "shape" the precompressed video to adapt to the fluctuating bandwidth. In our earlier work, rate shaping was extended to shape the...

Integrated Analyses of Copy Number Variations and Gene Expression in Lung Adenocarcinoma

Numerous efforts have been made to elucidate the etiology and improve the treatment of lung cancer, but the overall five-year survival rate is still only 15%. Identification of prognostic biomarkers for lung cancer using gene expression microarrays poses a major challenge in that very few overlapping genes have been reported among different studies. To address this issue, we have...