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Diagnostic and prognostic value of microRNAs in cholangiocarcinoma: a systematic review and meta-analysis

Diagnostic and prognostic value of microRNAs in cholangiocarcinoma: a systematic review and meta-analysis Chao Sun,1 Jie Zhu,1 Bin Wu,1 Jianlei Chen,1 Zhenwei Zhu,1 Peng Cai,1 Wanliang Guo,2 Zhicheng

Low-Overhead Paxos Replication

Log replication is a key component in highly available database systems. In order to guarantee data consistency and reliability, it is common for modern database systems to utilize Paxos protocol, which is responsible for replicating transactional logs from one primary node to multiple backups. However, the Paxos replication needs to store and synchronize some additional metadata...

Energy metabolic dysfunction as a carcinogenic factor in cancer cells

Cancer, as a leading cause of death, has attracted enormous public attention. Reprogramming of cellular energy metabolism is deemed to be one of the principal hallmarks of cancer. In this article, we reviewed the mutual relationships among environmental pollution factors, energy metabolic dysfunction, and various cancers. We found that most environmental pollution factors could...

Coupling Mechanism of Electromagnetic Field and Thermal Stress on Drosophila melanogaster

Temperature is an important factor in research on the biological effects of extremely low-frequency electromagnetic field (ELF-EMF), but interactions between ELF-EMF and temperature remain unknown. The effects of ELF-EMF (50 Hz, 3 mT) on the lifespan, locomotion, heat shock response (HSR), and oxidative stress (OS) of Canton-Special (CS) and mutant w1118 flies were investigated...

Associations Between CYP2B6 rs707265, rs1042389, rs2054675, and Hirschsprung Disease in a Chinese Population

Background Previous studies suggested that cytochrome P450 participated in the tumor metastasis and migration. CYP2B6 also acts as an important enzyme which metabolize partially or primarily metabolism of drugs, environmental contaminants, and mutagens. The objective of this study was to investigate the influence of CYP2B6 polymorphism on susceptibility of Hirschsprung disease...

Motion speed modulates walking direction discrimination: The role of the feet in biological motion perception

The human visual system is tuned to the motions of biological entities, which provide potentially vital information for survival. The current study examines the interplay between motion speed and motion direction perception. Following a brief presentation of a point-light walker walking straight ahead or slightly leftward or rightward, observers were asked to quickly judge the...

The Mitochondrial Genome of Paramphistomum cervi (Digenea), the First Representative for the Family Paramphistomidae

We determined the complete mitochondrial DNA (mtDNA) sequence of a fluke, Paramphistomum cervi (Digenea: Paramphistomidae). This genome (14,014 bp) is slightly larger than that of Clonorchis sinensis (13,875 bp), but smaller than those of other digenean species. The mt genome of P. cervi contains 12 protein-coding genes, 22 transfer RNA genes, 2 ribosomal RNA genes and 2 non...

Mapping codon usage of the translation initiation region in porcine reproductive and respiratory syndrome virus genome

Background Porcine reproductive and respitatory syndrome virus (PRRSV) is a recently emerged pathogen and severely affects swine populations worldwide. The replication of PRRSV is tightly controlled by viral gene expression and the codon usage of translation initiation region within each gene could potentially regulate the translation rate. Therefore, a better understanding of...

Development and validation of an ELISA using a protein encoded by ORF2 antigenic domain of porcine circovirus type 2

-Jun Shang 0 Xue-Peng Cai 0 Xiang-Tao Liu 0 0 State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute

Complete mitochondrial genomes of Taenia multiceps, T. hydatigena and T. pisiformis: additional molecular markers for a tapeworm genus of human and animal health significance

Background Mitochondrial genomes provide a rich source of molecular variation of proven and widespread utility in molecular ecology, population genetics and evolutionary biology. The tapeworm genus Taenia includes a diversity of tapeworm parasites of significant human and veterinary importance. Here we add complete sequences of the mt genomes of T. multiceps, T. hydatigena and T...