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57 papers found.
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Higher yields of hybrid rice do not depend on nitrogen fertilization under moderate to high soil fertility conditions

Background Increasing rice yield with fewer external inputs is critical to ensuring food security, reducing environmental costs, and improving returns. Use of hybrid rice has expanded greatly in China due to its higher yield potential. Meanwhile, large and increasing amounts of nitrogen (N) fertilizers have been used for expanding rice production in China. It is not clear to what...

In situ reaction mechanism of MgAlON in Al–Al2O3–MgO composites at 1700°C under flowing N2

The Al–Al2O3–MgO composites with added aluminum contents of approximately 0wt%, 5wt%, and 10wt%, named as M1, M2, and M3, respectively, were prepared at 1700°C for 5 h under a flowing N2 atmosphere using the reaction sintering method. After sintering, the Al–Al2O3–MgO composites were characterized and analyzed by X-ray diffraction, scanning electron microscopy, and energy...

Forecasting energy demand using neural-network-based grey residual modification models

Grey forecasting models have taken an important role for forecasting energy demand, particularly the GM(1,1) model, because they are able to construct a forecasting model using a limited samples without statistical assumptions. To improve prediction accuracy of a GM(1,1) model, its predicted values are often adjusted by establishing a residual GM(1,1) model, which together form a...

Microwave absorption properties of SiC@SiO2@Fe3O4 hybrids in the 2–18 GHz range

To enhance the microwave absorption performance of silicon carbide nanowires (SiCNWs), SiO2 nanoshells with a thickness of approximately 2 nm and Fe3O4 nanoparticles were grown on the surface of SiCNWs to form SiC@SiO2@Fe3O4 hybrids. The microwave absorption performance of the SiC@SiO2@Fe3O4 hybrids with different thicknesses was investigated in the frequency range from 2 to 18...

Quality control of single-cell RNA-seq by SinQC

Summary: Single-cell RNA-seq (scRNA-seq) is emerging as a promising technology for profiling cell-to-cell variability in cell populations. However, the combination of technical noise and intrinsic biological variability makes detecting technical artifacts in scRNA-seq samples particularly challenging. Proper detection of technical artifacts is critical to prevent spurious results...

miR-589-5p inhibits MAP3K8 and suppresses CD90 + cancer stem cells in hepatocellular carcinoma

Background Cancer stem cells (CSCs) are important in the tumorigenesis and progression of hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) play crucial roles regulating CD133 + and EpCAM + CSCs in HCC, although it is unclear whether miRNAs regulate CD90 + CSCs in HCC. Methods The miRNA profiles of CD90 + and CD90 - HCC cells were analyzed using a miRNA microarray and...

Temperature-Related Yield Constraints of Early-Rice in South China: A Cross-Location Analysis

Warm temperature during post-heading is generally hypothesized to be the critical factor limiting grain yield of early-rice in South China. However, there is no direct evidence to confirm this hypothesis in the field. This study was conducted to determine the temperature-related yield constraints of early-rice in South China. Field experiments were carried out in Huaiji (a...

CCAT: Combinatorial Code Analysis Tool for transcriptional regulation

Combinatorial interplay among transcription factors (TFs) is an important mechanism by which transcriptional regulatory specificity is achieved. However, despite the increasing number of TFs for which either binding specificities or genome-wide occupancy data are known, knowledge about cooperativity between TFs remains limited. To address this, we developed a computational...

Motor neuron-derived Thsd7a is essential for zebrafish vascular development via the Notch-dll4 signaling pathway

Background Development of neural and vascular systems displays astonishing similarities among vertebrates. This parallelism is under a precise control of complex guidance signals and neurovascular interactions. Previously, our group identified a highly conserved neural protein called thrombospondin type I domain containing 7A (THSD7A). Soluble THSD7A promoted and guided...

Reliability and Validity of the Perfusion, Extent, Depth, Infection and Sensation (PEDIS) Classification System and Score in Patients with Diabetic Foot Ulcer

Aims To validate the perfusion, extent, depth, infection and sensation (PEDIS) classification system and to make the clinical practice easier, we created a score system and compared this system with two previously published common score systems. Methods A retrospective cohort study was conducted on patients with diabetic foot ulcer (DFU) attending our hospital (n=364) from May...

Regulation of the pentose phosphate pathway in cancer

, pyruvate kinase (PK)-M2; PPP, pentose phosphate pathway; PTEN, phosphatase and tensin homologue; TKT, transketolase. COMPLIANCE WITH ETHICS GUIDELINES Peng Jiang, Wenjing Du and Mian Wu declare that they

Comprehensive analyses of tumor immunity: implications for cancer immunotherapy

Background Understanding the interactions between tumor and the host immune system is critical to finding prognostic biomarkers, reducing drug resistance, and developing new therapies. Novel computational methods are needed to estimate tumor-infiltrating immune cells and understand tumor–immune interactions in cancers. Results We analyze tumor-infiltrating immune cells in over 10...

The co-expression of MMP-9 and Tenascin-C is significantly associated with the progression and prognosis of pancreatic cancer

Background Matrix metalloproteinase-9 (MMP-9) and Tenascin-C (TN-C) have been shown to be involved in the metastasis of many tumors. The purpose of this study was to determine the relationship between the co-expression of these two molecules and the clinical prognosis of pancreatic cancer. Methods We investigated the expression of TN-C and MMP-9 in 103 pancreatic cancer tissues...

Chloroplast Transformation of Platymonas (Tetraselmis) subcordiformis with the bar Gene as Selectable Marker

The objective of this research was to establish a chloroplast transformation technique for Platymonas (Tetraselmis) subcordiformis. Employing the gfp gene as a reporter and the bar gene as a selectable marker, transformation vectors of P. subcordiformis chloroplast were constructed with endogenous fragments rrn16S–trnI (left) and trnA–rrn23S (right) as a recombination site of the...

The contribution of Alu exons to the human proteome

Background Alu elements are major contributors to lineage-specific new exons in primate and human genomes. Recent studies indicate that some Alu exons have high transcript inclusion levels or tissue-specific splicing profiles, and may play important regulatory roles in modulating mRNA degradation or translational efficiency. However, the contribution of Alu exons to the human...

Primary renal squamous cell carcinoma mimicking the renal cyst: a case report and review of the recent literature

Background Renal squamous cell carcinoma is a rare neoplasm with poor prognosis. Chronic irritation from nephrolithiasis and/or pyelonephritis is the leading cause. Case presentation We described a 51-year-old male patient who was admitted because of left flank pain. Ultrasonography showed a renal cyst containing calculus. However, contrast-enhanced ultrasonography and CT scan...

Inhibition of Glycoprotein VI Clustering by Collagen as a Mechanism of Inhibiting Collagen-Induced Platelet Responses: The Example of Losartan

Exposure of platelets to collagen triggers the formation of a platelet clot. Pharmacological agents capable of inhibiting platelet activation by collagen are thus of potential therapeutic interest. Thrombus formation is initiated by the interaction of the GPIb-V-IX complex with collagen-bound vWF, while GPVI interaction with collagen triggers platelet activation that is...

Network analysis of gene essentiality in functional genomics experiments

Many genomic techniques have been developed to study gene essentiality genome-wide, such as CRISPR and shRNA screens. Our analyses of public CRISPR screens suggest protein interaction networks, when integrated with gene expression or histone marks, are highly predictive of gene essentiality. Meanwhile, the quality of CRISPR and shRNA screen results can be significantly enhanced...

Potential Yield Increase of Hybrid Rice at Five Locations in Southern China

Background A number of field studies have demonstrated that the yield potential of hybrid rice cultivars is higher than that of inbred cultivars, although the magnitude of difference between hybrid and inbred cultivars at different yield levels has not been described. The objective of this study is to compare the yield increase potential at different yield levels between hybrid...

Computational Assessment of the Cooperativity between RNA Binding Proteins and MicroRNAs in Transcript Decay

Transcript degradation is a widespread and important mechanism for regulating protein abundance. Two major regulators of transcript degradation are RNA Binding Proteins (RBPs) and microRNAs (miRNAs). We computationally explored whether RBPs and miRNAs cooperate to promote transcript decay. We defined five RBP motifs based on the evolutionary conservation of their recognition...