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Efficacy and safety of saxagliptin in patients with type 2 diabetes: A systematic review and meta-analysis

(saxagliptin vs active comparators)]. (EPS) Author Contributions Conceptualization: Peng Men, Hui-lin Tang, Suo-di Zhai. Investigation: Peng Men. Methodology: Peng Men, Hui-lin Tang. 14 / 18 Project ... administration: Suo-di Zhai. Writing ± original draft: Peng Men. Writing ± review & editing: Xiao-tong Li, Suo-di Zhai. 15 / 18 16 / 18 17 / 18 1. Ogurtsova K , da Rocha Fernandes JD , Huang Y , Linnenkamp U

Impact of dipeptidyl peptidase-4 inhibitors on serum adiponectin: a meta-analysis

Background Adiponectin, an adipose-specific protein, is negatively correlated with pro-atherogenic low-density lipoprotein cholesterol (LDL-C) and other cardiovascular risk factors such as insulin resistance. Therefore, low levels of adiponectin are associated with a higher risk for diabetes and cardiovascular disease. Dipeptidyl peptidase-4 inhibitors (DPP4i) have been used for...

Association between the AUC0-24/MIC Ratio of Vancomycin and Its Clinical Effectiveness: A Systematic Review and Meta-Analysis

Background A target AUC0-24/MIC ratio of 400 has been associated with its clinical success when treating Staphylococcus aureus infections but is not currently supported by state-of-the-art evidence-based research. Objective This current systematic review aimed to evaluate the available evidence for the association between the AUC0-24/MIC ratio of vancomycin and its clinical...