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Targeted CGRP Small Molecule Antagonists for Acute Migraine Therapy

Migraine is a highly prevalent, severe, and disabling neurological condition with a significant unmet need for effective acute therapies. Patients (~50%) are dissatisfied with their currently available therapies. Calcitonin gene-related peptide (CGRP) has emerged as a key neuropeptide involved in the pathophysiology of migraines. As reviewed in this manuscript, a number of small...

Treatment of disabling headache with greater occipital nerve injections in a large population of childhood and adolescent patients: a service evaluation

evaluation Francesca Puledda 0 Peter J. Goadsby 0 Prab Prabhakar 0 Headache Group, Department of Basic and Clinical Neuroscience, King's College London, and NIHR-Wellcome Trust King's Clinical Research

Anti-CGRP Monoclonal Antibodies: the Next Era of Migraine Prevention?

no conflict of interest. Peter J. Goadsby has received grants and personal fees from Amgen and Eli-Lilly and Company and personal fees from Alder Biopharmaceuticals, Novartis, Teva Pharmaceuticals

An update on migraine: current understanding and future directions

Migraine is a common brain disorder with high disability rates which involves a series of abnormal neuronal networks, interacting at different levels of the central and peripheral nervous system. An increase in the interest around migraine pathophysiology has allowed researchers to unravel certain neurophysiological mechanisms and neurotransmitter involvement culminating in the...

Current Approaches to Neuromodulation in Primary Headaches: Focus on Vagal Nerve and Sphenopalatine Ganglion Stimulation

Facility, King's College London , London , UK 3 Peter J. Goadsby Neuromodulation is a promising, novel approach f o r t h e t r e a t m e n t o f p r i m a r y h e a d a c h e d i s o r d e r s ... . Peter J. Goadsby declares grant support and personal fees from Allergan, eNeura Inc. and Amgen Inc.; he also declares personal fees from Autonomic Technologies Inc., Alder Biopharmaceuticals, Pfizer Inc

Calcitonin gene-related peptide and pain: a systematic review

Background Calcitonin gene-related peptide (CGRP) is widely distributed in nociceptive pathways in human peripheral and central nervous system and its receptors are also expressed in pain pathways. CGRP is involved in migraine pathophysiology but its role in non-headache pain has not been clarified. Methods We performed a systematic literature search on PubMed, Embase and...

Postoperative hemicrania continua-like headache - a case series

Background Hemicrania continua (HC) is a rare chronic headache disorder, typically accompanied by cranial autonomic features and responding to therapeutic doses of indomethacin. The pathophysiology of hemicrania continua is not fully understood. Findings We report a series of three patients who developed a continuous hemicranial headache after cranial surgery. Each case presented...

The origin of nausea in migraine–A PET study

Background Nausea is a common and disabling symptom of migraine. The origin of nausea is not well understood although functional connections between trigeminal neurons and the nucleus tractus solitarius may explain occurrence of nausea with pain. However, nausea occurs as a premonitory symptom in about a quarter of patients, suggesting that a primary brain alteration unrelated to...

Single-pulse transcranial magnetic stimulation (sTMS) for the acute treatment of migraine: evaluation of outcome data for the UK post market pilot program

Background Single pulse transcranial magnetic stimulation (sTMS) is a novel treatment for acute migraine. Previous randomised controlled data demonstrated that sTMS is effective and well tolerated in the treatment of migraine with aura. The aim of the programme reported here was to evaluate patient responses in the setting of routine clinical practice. Methods Migraine patients...

New onset migraine with aura after treatment initiation with ivabradine

Background Migraine with aura is a complex neurological disorder modeled in animals by cortical spreading depression. It is less usual to find complete animal models for the disease so any opportunity to test a human effect back at the bench is welcome. Findings We report the case of a 24 year old woman who developed new onset episodic migraine with visual aura shortly after...


0 Peter J. Goadsby, M.D. , Ph.D., D. Sc . Headache Group Department of Neurology University of California , San Francisco San Francisco, California Migraine is a highly disabling,1 common,2 and ... certainly be welcomed by many migraineurs. Disclosure For the last 3 years, Peter J. Goadsby has been a consultant, advisor, and/or collaborator for Advanced Bionics, Allergan, Almirall, Amgen, ATI

Enhancing cognitive-behavioural therapy for recurrent headache: design of a randomised controlled trial

Background We have argued against the traditional approach of counselling avoidance of all triggers of headaches and migraine. Problems with this approach include the impossibility of avoiding all triggers and the high costs associated with trying to do so, and that avoidance could lead to reduced tolerance for the triggers. We have developed an alternative approach called...

Update on Hemicrania Continua

Dr. E. Cittadini: none; Dr. Peter J. Goadsby has served as a board member for Allergan; CoLucid Pharmaceuticals; MAP Pharmaceuticals, Inc.; Merck, Sharpe, and Dohme; Neuralieve; NeurAxon; ATI

Migraine among medical students in Kuwait University

Background Medical students routinely have triggers, notably stress and irregular sleep, which are typically associated with migraine. We hypothesized that they may be at higher risk to manifest migraine. We aimed to determine the prevalence of migraine among medical students in Kuwait University. Methods This is cross-sectional, questionnaire-based study. Participants who had...

Migraine misdiagnosis as a sinusitis, a delay that can last for many years

Background Sinusitis is the most frequent misdiagnosis given to patients with migraine. Therefore we decided to estimate the frequency of misdiagnosis of sinusitis among migraine patients. Methods The study included migraine patients with a past history of sinusitis. All included cases fulfilled the International Classification of Headache Disorders, 3rd edition (ICHD-III- beta...