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6 papers found.
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Using an Extracurricular Honors Program to Engage Future Physicians Into Scientific Research in Early Stages of Medical Training

Physician-scientists are urgently needed to make progress in the dynamic world of medical healthcare. Currently, there is a worldwide shortage in physicians pursuing a scientific career. Actively engaging students in research in early stages of medical training could help to direct students towards a scientific career and contribute to creating the next generation of physician...

The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development

, Margreet R. de Vries, Peter J. van den Elsen, Paul H. A. Quax. Formal analysis: Rob C. M. de Jong, Mark M. Ewing, Margreet R. de Vries. Investigation: Rob C. M. de Jong, Mark M. Ewing, Margreet R. de ... . Writing ± original draft: Rob C. M. de Jong, Mark M. Ewing, Margreet R. de Vries. Writing ± review & editing: Peter J. van den Elsen, CeÂline Gongora, J. Wouter Jukema, Paul H. A. Quax. 14 / 16 14. Huang J

Upregulation of HLA Expression in Primary Uveal Melanoma by Infiltrating Leukocytes

Introduction Uveal melanoma (UM) with an inflammatory phenotype, characterized by infiltrating leukocytes and increased human leukocyte antigen (HLA) expression, carry an increased risk of death due to metastases. These tumors should be ideal for T-cell based therapies, yet it is not clear why prognostically-infaust tumors have a high HLA expression. We set out to determine...

Antigen-independent acquisition of MHC class II molecules by human T lymphocytes

We report here that human T lymphocytes have the capacity of acquiring large amounts of MHC class II molecules from various types of antigen-presenting cells (APC) in an antigen-independent manner. The transfer of MHC class II molecules from APC to T cell required direct cell-to-cell contact and appeared to involve the interaction of numerous adhesion molecules between these...

Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation

-Baert Peter J van den Elsen Paul van der Valk Sandra Amor 0 Department of Molecular Cell Biology and Immunology/Neuropathology, VU University Medical Center , Van der Boechorststraat 7, 1081BT, Amsterdam

Longitudinal analysis of T cells responding to tetanus toxoid in healthy subjects as well as in pediatric patients after bone marrow transplantation: the identification of identical TCR–CDR3 regions in time suggests long-term stability of at least part of the antigen-specific TCR repertoire

To understand the nature of long-term Th immune responses, we investigated in the present study the TCRBV gene repertoire of CD4+ T cells specific for the recall antigen tetanus toxoid (TT) in recipients of an allogeneic bone marrow transplantation (allo-BMT) at several time points after transplantation and in their BM donors. We observed that the TCR repertoire of TT-specific...