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6 papers found.
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A prospective observational study of 56 patients treated with ring fixator after a complex tibial fracture

The objective of this prospective study was to evaluate the patient-reported outcomes for patients with complex tibial fractures treated with a ring fixator. The secondary aim was to analyse the variables affecting patient-reported outcomes and time to union. Fifty-six patients participated in the study. The mean age at the time of fracture was 56.5 years (range 30–86). All ...

Optimal 2-[18F]fluoro-2-deoxy-d-galactose PET/CT protocol for detection of hepatocellular carcinoma

Background Positron emission tomography (PET) with the liver-specific galactose tracer 2-[18F]fluoro-2-deoxy-d-galactose (18F-FDGal) may improve diagnosis of hepatocellular carcinoma (HCC). The aim of this study was to test which of three different 18F-FDGal PET protocols gives the highest tumour-to-background (T/B) ratio on PET images and thus better detection of HCC tumours. ...

Microbial Bebop: Creating Music from Complex Dynamics in Microbial Ecology

In order for society to make effective policy decisions on complex and far-reaching subjects, such as appropriate responses to global climate change, scientists must effectively communicate complex results to the non-scientifically specialized public. However, there are few ways however to transform highly complicated scientific data into formats that are engaging to the general ...

Differential Expression of hERG1 Channel Isoforms Reproduces Properties of Native IKr and Modulates Cardiac Action Potential Characteristics

Background The repolarizing cardiac rapid delayed rectifier current, IKr, is composed of ERG1 channels. It has been suggested that two isoforms of the ERG1 protein, ERG1a and ERG1b, both contribute to IKr. Marked heterogeneity in the kinetic properties of native IKr has been described. We hypothesized that the heterogeneity of native IKr can be reproduced by differential expression ...

Rank-based edge reconstruction for scale-free genetic regulatory networks

Background The reconstruction of genetic regulatory networks from microarray gene expression data has been a challenging task in bioinformatics. Various approaches to this problem have been proposed, however, they do not take into account the topological characteristics of the targeted networks while reconstructing them. Results In this study, an algorithm that explores the ...

A statistical method to incorporate biological knowledge for generating testable novel gene regulatory interactions from microarray experiments

Background The incorporation of prior biological knowledge in the analysis of microarray data has become important in the reconstruction of transcription regulatory networks in a cell. Most of the current research has been focused on the integration of multiple sets of microarray data as well as curated databases for a genome scale reconstruction. However, individual researchers ...