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Chlorhexidine and octenidine susceptibility of bacterial isolates from clinical samples in a three-armed cluster randomised decolonisation trial

laboratories participating in and supporting the CLIP-ID trial. Author Contributions Conceptualization: Luisa A. Denkel, Petra Gastmeier, Christine Geffers. Data curation: Luisa A. Denkel. Formal analysis ... : Luisa A. Denkel, Frank Schwab. Funding acquisition: Petra Gastmeier, Christine Geffers. Investigation: Luisa A. Denkel, Jennifer Golembus, Solvy Wolke. Methodology: Luisa A. Denkel, Tobias S. Kramer

Summer, sun and sepsis—The influence of outside temperature on nosocomial bloodstream infections: A cohort study and review of the literature

: Frank Schwab, Petra Gastmeier, Peter Hoffmann, Elisabeth Meyer. Data curation: Frank Schwab, Peter Hoffmann. Formal analysis: Frank Schwab. Funding acquisition: Petra Gastmeier, Peter Hoffmann ... . Investigation: Elisabeth Meyer. Project administration: Petra Gastmeier. Resources: Frank Schwab, Peter Hoffmann. Supervision: Frank Schwab, Petra Gastmeier. Validation: Frank Schwab, Peter Hoffmann

ICU mortality following ICU-acquired primary bloodstream infections according to the type of pathogen: A prospective cohort study in 937 Germany ICUs (2006-2015)

Sepsis Update in Weimar, Germany 2015. Author Contributions Conceptualization: Frank Schwab, Christine Geffers, Petra Gastmeier. Data curation: Frank Schwab, Michael Behnke. Formal analysis: Frank ... Schwab. Methodology: Frank Schwab, Christine Geffers, Petra Gastmeier. Project administration: Petra Gastmeier. Resources: Michael Behnke. Supervision: Christine Geffers, Petra Gastmeier. Validation

Antibiotic use, knowledge and health literacy among the general population in Berlin, Germany and its surrounding rural areas

. Gellert. Acknowledgments We want to thank Gerald Brennan for proof-reading the manuscript. Author Contributions Conceptualization: Florian Salm, Clemens Ernsting, Adelheid Kuhlmey, Petra Gastmeier. Data ... curation: Clemens Ernsting, Melanie Kanzler, Paul Gellert. Formal analysis: Florian Salm, Paul Gellert. Investigation: Florian Salm, Clemens Ernsting, Melanie Kanzler, Petra Gastmeier, Paul Methodology

Pathogen-specific mortality in very low birth weight infants with primary bloodstream infection

Objective Mortality in very low birth weight infants following microbiology confirmed primary bloodstream infections varies with the type of causative pathogen. Given evidence from other studies that infections with gram negative bacteria and fungi cause a higher case fatality risk. We tried to confirm this in a nation-wide multi-center trial. Methods A cohort of 55,465 very low...

Lean back and wait for the alarm? Testing an automated alarm system for nosocomial outbreaks to provide support for infection control professionals

, Petra Gastmeier, Michael Behnke. Data curation: Luis Alberto Peña Diaz, Brar Piening. Funding acquisition: Rasmus Leistner, Michael Behnke. Methodology: Christin Schro¨der. Project administration ... . Supervision: Petra Gastmeier, Rasmus Leistner, Michael Behnke. Validation: Anna Maria Rohde. 13 / 15 Visualization: Christin Schro¨der. Writing – original draft: Christin Schro¨der, Rasmus Leistner. Writing

Pyoderma outbreak among kindergarten families: Association with a Panton-Valentine leukocidin (PVL)-producing S. aureus strain

-Burrus, Irina Zuschneid, Nicoletta Wischnewski, Jennifer Bender, Michaela Niebank, Carmen Scheibenbogen, Leif G. Hanitsch. Resources: Rasmus Leistner, Petra Gastmeier. Software: Rasmus Leistner, Leif G ... . Hanitsch. Supervision: Rasmus Leistner, Axel Kola, Petra Gastmeier, Renate KruÈger, Pia-Alice Hoppe, Sylke Schneider-Burrus, Irina Zuschneid, Nicoletta Wischnewski, Jennifer Bender, Fran ziska Layer

The Warmer the Weather, the More Gram-Negative Bacteria - Impact of Temperature on Clinical Isolates in Intensive Care Units

Background We investigated the relationship between average monthly temperature and the most common clinical pathogens causing infections in intensive care patients. Methods A prospective unit-based study in 73 German intensive care units located in 41 different hospitals and 31 different cities with total 188,949 pathogen isolates (102,377 Gram-positives and 86,572 Gram...

Admission prevalence of colonization with third-generation cephalosporin-resistant Enterobacteriaceae and subsequent infection rates in a German university hospital

analysis, Norbert Thoma for his kind support in medical database analysis and Gerald Brennan for proofreading. Author Contributions Conceptualization: Janine Zweigner, Petra Gastmeier. Formal analysis ... : Frank Schwab, Rasmus Leistner. Investigation: Anne-Cathe?rine Boldt, Minh Trang Bui, Nayana Ma?rtin, Marina Kipnis. Methodology: Petra Gastmeier. Project administration: Anna M. Rohde, Janine Zweigner

Protective Effect of Dual-Strain Probiotics in Preterm Infants: A Multi-Center Time Series Analysis

Objective To determine the effect of dual-strain probiotics on the development of necrotizing enterocolitis (NEC), mortality and nosocomial bloodstream infections (BSI) in preterm infants in German neonatal intensive care units (NICUs). Design A multi-center interrupted time series analysis. Setting 44 German NICUs with routine use of dual-strain probiotics on neonatal ward level...

Prolonged outbreak of clonal MDR Pseudomonas aeruginosa on an intensive care unit: contaminated sinks and contamination of ultra-filtrate bags as possible route of transmission?

Background We report on an outbreak in a surgical, interdisciplinary intensive care unit (ICU) of a tertiary care hospital. We detected a cluster of ICU patients colonized or infected with multidrug-resistant Pseudomonas aeruginosa. We established an outbreak investigation team, performed an exploratory epidemiological analysis and initiated an epidemiology-based intervention...

Antibiotic prescribing behavior among general practitioners – a questionnaire-based study in Germany

Brennan for proof-reading the manuscript. Members of the RAI-Study group. Muna Abu Sin, Esther-Maria Antao, Michael Behnke, Evgeniya Boklage, Tim Eckmanns, Christina Forstner, Petra Gastmeier, Jochen

Health care workers causing large nosocomial outbreaks: a systematic review

Staff in the hospital itself may be the source of a nosocomial outbreak (NO). But the role of undetected carriers as an outbreak source is yet unknown. A systematic review was conducted to evaluate outbreaks caused by health care workers (HCW). The Worldwide Outbreak Database and PubMed served as primary sources of data. Articles in English, German or French were included. Other...

The step from a voluntary to a mandatory national nosocomial infection surveillance system: the influence on infection rates and surveillance effect

Background The German national nosocomial infection surveillance system, KISS, has a component for very low birth weight (VLBW) infants (called NEO-KISS) which changed from a system with voluntary participation and confidential data feedback to a system with mandatory participation and confidential feedback. Methods In order to compare voluntary and mandatory surveillance data...

Sepsis Caused by Extended-Spectrum Beta-Lactamase (ESBL)-Positive K. pneumoniae and E. coli: Comparison of Severity of Sepsis, Delay of Anti-Infective Therapy and ESBL Genotype

Infections with extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) are associated with increased mortality. Outcome differences due to various species of ESBL-E or ESBL genotypes are not well investigated. We conducted a cohort study to assess risk factors for mortality in cases of ESBL-E bacteremia (K. pneumoniae or E. coli) and the risk factors for sepsis...

Nosocomial methicillin resistant Staphylococcus aureus pneumonia - epidemiology and trends based on data of a network of 586 German ICUs (2005-2009)

The epidemiology of MRSA pneumonia varies across countries. One of the most import risk factors for the development of nosocomial MRSA pneumonia is mechanical ventilation. Methicillin resistance in S. aureus ventilator associated pneumonia (VAP) ranged between 37% in German, 54% in the US American and 78% in Asian and Latin American ICUs. In 2009, the incidence density of...

Individual units rather than entire hospital as the basis for improvement: the example of two Methicillin resistant Staphylococcus aureus cohort studies

Background Two MRSA surveillance components exist within the German national nosocomial infection surveillance system KISS: one for the whole hospital (i.e. only hospital based data and no rates for individual units) and one for ICU-based data (rates for each individual ICU). The objective of this study was to analyze which surveillance system (a hospital based or a unit based...