The anterior insular cortex plays a key role in the representation of interoceptive effects of drug and natural rewards and their integration with attention, executive function, and emotions, making it a potential target region for intervention to control appetitive behaviors. Here, we investigated the effects of chemogenetic stimulation or inhibition of the anterior insula on...
Pharmacological research in mice and human genetic analyses suggest that the kallikrein-kinin system (KKS) may regulate anxiety. We examined the role of the KKS in anxiety and stress in both species. In human genetic association analysis, variants in genes for the bradykinin precursor (KNG1) and the bradykinin receptors (BDKRB1 and BDKRB2) were associated with anxiety disorders...
The glycine transporter-1 inhibitor Org25935 is a promising candidate in a treatment concept for alcohol use disorder targeting the glycine system. Org25935 inhibits ethanol-induced dopamine elevation in brain reward regions and reduces ethanol intake in Wistar rats. This study aimed to further characterise the compound and used ethanol consumption, behavioral measures, and gene...
HovattaDepartment of Pharmacology, University of Helsinki, Helsinki, FinlandMateusz Dudek & Petri Hyytiä AuthorsSearch for Mikaela A Laine in:Nature Research journals • PubMed • Google Scholar Search for Ewa ... • PubMed • Google Scholar Search for Petri Hyytiä in:Nature Research journals • PubMed • Google Scholar Search for Iiris Hovatta in:Nature Research journals • PubMed • Google Scholar Contributions P.H
AffiliationsDepartment of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, FinlandPia Bäckström & Petri Hyytiä AuthorsSearch for Pia Bäckström in:Nature Research journals • PubMed • Google ... ScholarSearch for Petri Hyytiä in:Nature Research journals • PubMed • Google Scholar Corresponding author Correspondence to Petri Hyytiä. Rights and permissions To obtain permission to re-use content from
• PubMed • Google Scholar Search for Daniel Bachteler in:Nature Research journals • PubMed • Google Scholar Search for Sabrina Koch in:Nature Research journals • PubMed • Google Scholar Search for Petri ... Hyytiä in:Nature Research journals • PubMed • Google Scholar Search for Rainer Spanagel in:Nature Research journals • PubMed • Google Scholar Corresponding author Correspondence to Daniel Bachteler
Endocannabinoid signaling has recently been implicated in ethanol-seeking behavior. We analyzed the expression of endocannabinoid-related genes in key brain regions of reward and dependence, and compared them between the alcohol-preferring AA (Alko Alcohol) and nonpreferring ANA (Alko Non-Alcohol) rat lines. A decreased expression of fatty acid amidohydrolase (FAAH), the main...
