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Structure and function of the Nppa–Nppb cluster locus during heart development and disease

Medical Center, University of Amsterdam , Meibergdreef 15, 1105 AZ Amsterdam , The Netherlands 1 Vincent M. Christoffels 2 Phil Barnett Atrial natriuretic factor and brain natriuretic peptide are two

Follistatin-like 1 in development and human diseases

Follistatin-like 1 (FSTL1) is a secreted glycoprotein displaying expression changes during development and disease, among which cardiovascular disease, cancer, and arthritis. The cardioprotective role of FSTL1 has been intensively studied over the last years, though its mechanism of action remains elusive. FSTL1 is involved in multiple signaling pathways and biological processes...

OccuPeak: ChIP-Seq Peak Calling Based on Internal Background Modelling

ChIP-seq has become a major tool for the genome-wide identification of transcription factor binding or histone modification sites. Most peak-calling algorithms require input control datasets to model the occurrence of background reads to account for local sequencing and GC bias. However, the GC-content of reads in Input-seq datasets deviates significantly from that in ChIP-seq...

Cardiac regeneration: different cells same goal

Phil Barnett 0 Maurice J. B. van den Hoff 0 0 P. Barnett M. J. B. van den Hoff (&) Department of Anatomy, Embryology and Physiology, Heart Failure Research Center, Academic Medical Center

Tbx2 Controls Lung Growth by Direct Repression of the Cell Cycle Inhibitor Genes Cdkn1a and Cdkn1b

Vertebrate organ development relies on the precise spatiotemporal orchestration of proliferation rates and differentiation patterns in adjacent tissue compartments. The underlying integration of patterning and cell cycle control during organogenesis is insufficiently understood. Here, we have investigated the function of the patterning T-box transcription factor gene Tbx2 in lung...

Mass-dependent predation risk as a mechanism for house sparrow declines?

Ross MacLeod () Phil Barnett Jacquie Clark Will Cresswell 0 BTO , The Nunnery, Thetford, Norfolk IP24 2PU , UK 1 Department of Environmental and Evolutionary Biology, Institute of Biological and Life

Twenty-eight genetic loci associated with ST-T-wave amplitudes of the electrocardiogram

Marten E. Van Den Berg Leo-Pekka Lyytikäinen Phil Barnett Xinchen Wang LifeLines Cohort Study Elsayed Z. Soliman Cornelia M. Van Duijn Mika Kähönen Dirk J. Van Veldhuisen Jan A. Kors Olli T. Raitakari

Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation

A key step in heart development is the coordinated development of the atrioventricular canal (AVC), the constriction between the atria and ventricles that electrically and physically separates the chambers, and the development of the atrioventricular valves that ensure unidirectional blood flow. Using knock-out and inducible overexpression mouse models, we provide evidence that...