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Induction and maintenance of bi-functional (IFN-γ + IL-2+ and IL-2+ TNF-α+) T cell responses by DNA prime MVA boosted subtype C prophylactic vaccine tested in a Phase I trial in India

, Srikanth Prasad Tripathy, Hanna Elizabeth Luke. Data curation: Sivasankaran Munusamy Ponnan, Kannan Thiruvengadam, Rajat Goyal, Philip Bergin, Jakub T. Kopycinski, Jill Gilmour, Srikanth Prasad Tripathy ... , Hanna Elizabeth Luke. Formal analysis: Sivasankaran Munusamy Ponnan, Sathyamurthy Pattabiram, Kannan Thiruvengadam, Rajat Goyal, Shweta Chatrath, Philip Bergin, Jakub T. Kopycinski, Jill Gilmour, Sriram

Induction of circulating T follicular helper cells and regulatory T cells correlating with HIV-1 gp120 variable loop antibodies by a subtype C prophylactic vaccine tested in a Phase I trial in India

Goyal, Nikhil Singla, Philip Bergin. Data curation: Sivasankaran Munusamy Ponnan, Jakub T. Kopycinski. Formal analysis: Sivasankaran Munusamy Ponnan, Joyeeta Mukherjee, Jakub T. Kopycinski, Jill ... Gilmour. Funding acquisition: Soumya Swaminathan, Nikhil Singla, Joyeeta Mukherjee, Philip Bergin, Jill Gilmour, Hanna Elizabeth Luke. Investigation: Sivasankaran Munusamy Ponnan, Soumya Swaminathan

Phenotypic Alteration of Neutrophils in the Blood of HIV Seropositive Patients

We have recently identified a novel population of activated low-density granulocytes (LDGs) in peripheral blood mononuclear cells of HIV seropositive patients. LDGs have a similar morphology to normal density granulocytes (NDGs), but are phenotypically different. Here we measured the expression levels of different phenotypic markers of granulocytes in the blood of HIV...

Protein energy malnutrition increases arginase activity in monocytes and macrophages

Background Protein energy malnutrition is commonly associated with immune dysfunctions and is a major factor in susceptibility to infectious diseases. Methods In this study, we evaluated the impact of protein energy malnutrition on the capacity of monocytes and macrophages to upregulate arginase, an enzyme associated with immunosuppression and increased pathogen replication...

Protein energy malnutrition increases arginase activity in monocytes and macrophages

Protein energy malnutrition is commonly associated with immune dysfunctions and is a major factor in susceptibility to infectious diseases. In this study, we evaluated the impact of protein energy malnutrition on the capacity of monocytes and macrophages to upregulate arginase, an enzyme associated with immunosuppression and increased pathogen replication. Our results show that...

Characterization of Neutrophil Subsets in Healthy Human Pregnancies

Pregnancies Aloysius Ssemaganda Lindsay Kindinger Philip Bergin Leslie Nielsen Juliet Mpendo Ali Ssetaala Noah Kiwanuka Markus Munder Tiong Ghee Teoh Pascale Kropf Ingrid Mu ller Ana Claudia Zenclussen

First-in-Human Evaluation of the Safety and Immunogenicity of an Intranasally Administered Replication-Competent Sendai Virus–Vectored HIV Type 1 Gag Vaccine: Induction of Potent T-Cell or Antibody Responses in Prime-Boost Regimens

Background. We report the first-in-human safety and immunogenicity assessment of a prototype intranasally administered, replication-competent Sendai virus (SeV)–vectored, human immunodeficiency virus type 1 (HIV-1) vaccine. Methods. Sixty-five HIV-1–uninfected adults in Kenya, Rwanda, and the United Kingdom were assigned to receive 1 of 4 prime-boost regimens (administered at 0...

Viral Inhibition Assay: A CD8 T Cell Neutralization Assay for Use in Clinical Trials of HIV-1 Vaccine Candidates

We have characterized an assay measuring CD8 T cell-mediated inhibition of human immunodeficiency virus (HIV) type 1 replication, demonstrating specificity and reproducibility and employing a panel of primary HIV-1 isolates. The assay uses relatively simple autologous cell culture and enzyme-linked immunosorbent assay, avoids generation of T cell clones, and can be performed with...