Search: authors:"Philip M. Grant"

Modifying Antiretroviral Therapy in Virologically Suppressed HIV-1-Infected Patients

patient’s current therapy. Acknowledgments Sean E. Collins was supported in part by an NIH grant: T32 AI052073. Philip M. Grant was supported in part by an NIH grant: K23 AI108358-01. Robert W. Shafer was

Comparative effectiveness and cost-effectiveness of antiretroviral therapy and pre-exposure prophylaxis for HIV prevention in South Africa

Background Antiretroviral therapy (ART) and oral pre-exposure prophylaxis (PrEP) are effective in reducing HIV transmission in heterosexual adults. The epidemiologic impact and cost-effectiveness of combined prevention approaches in resource-limited settings remain unclear. Methods We develop a dynamic mathematical model of the HIV epidemic in South Africa’s adult population. We...

Comparative effectiveness and cost-effectiveness of antiretroviral therapy and pre-exposure prophylaxis for HIV prevention in South Africa

Antiretroviral therapy (ART) and oral pre-exposure prophylaxis (PrEP) are effective in reducing HIV transmission in heterosexual adults. The epidemiologic impact and cost-effectiveness of combined prevention approaches in resource-limited settings remain unclear. We develop a dynamic mathematical model of the HIV epidemic in South Africa’s adult population. We assume ART reduces...

Concerns Regarding a Randomized Study of the Timing of Antiretroviral Therapy in Zimbabweans with AIDS and Acute Cryptococcal Meningitis

Collaborative update of a rule-based expert system for HIV-1 genotypic resistance test interpretation

. Data curation: Roger Paredes, Philip L. Tzou, Gert van Zyl, Geoff Barrow, Ricardo Camacho, Sergio Carmona, Philip M. Grant, Ravindra K. Gupta, Raph L. Hamers, P. Richard Harrigan, Michael R. Jordan, Rami ... . Methodology: Gert van Zyl, Geoff Barrow, Ricardo Camacho, Sergio Carmona, Philip M. Grant, Ravindra K. Gupta, Raph L. Hamers, P. Richard Harrigan, Michael R. Jordan, Rami Kantor, David A. Katzenstein, Daniel R

Blood (1→3)-β-D-Glucan as a Diagnostic Test for HIV-Related Pneumocystis jirovecii Pneumonia

(See the editorial commentary by Morris and Masur, on pages 203–204.) Background. Improved noninvasive diagnostic tests for Pneumocystis jirovecii pneumonia (PCP) are needed. We evaluated the test characteristics of plasma (1→3)-β-D-glucan (β-glucan) for HIV-related PCP among a large group of patients presenting with diverse opportunistic infections (OIs). Methods. The study...

Elevated Interleukin 8 and T-Helper 1 and T-Helper 17 Cytokine Levels Prior to Antiretroviral Therapy in Participants Who Developed Immune Reconstitution Inflammatory Syndrome During ACTG A5164

Background. Immune reconstitution inflammatory syndrome (IRIS) reflects an aberrant immune response that can develop in human immunodeficiency virus–infected patients initiating antiretroviral therapy (ART). Its pathogenesis remains unclear. Methods. We performed a nested case-control study using specimens from ACTG A5164. We compared plasma biomarkers and T-cell subsets in 19...

Risk Factor Analyses for Immune Reconstitution Inflammatory Syndrome in a Randomized Study of Early vs. Deferred ART during an Opportunistic Infection

Background Immune reconstitution inflammatory syndrome (IRIS) is reported widely in patients initiating antiretroviral therapy (ART). However, few studies are prospective, and no study has evaluated the impact of the timing of ART when allocated randomly during an acute opportunistic infection (OI). Methodology/Principal Findings A5164 randomized 282 subjects with AIDS-related...