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New classification of HLA-DRB1 alleles in rheumatoid arthritis susceptibility: a combined analysis of worldwide samples

, Alain Cantagrel2,3, Anne Cambon-Thomsen1 and Pierre-Antoine Gourraud1,4 Corresponding author: Pierre-Antoine Gourraud 0 JE2510, University Paul Sabatier Toulouse III , 118 route de Narbonne, Toulouse

A new classification of HLA-DRB1 alleles differentiates predisposing and protective alleles for autoantibody production in rheumatoid arthritis

The HLA-DRB1 gene was reported to be associated with anticitrullinated protein/peptide autoantibody (ACPA) production in rheumatoid arthritis (RA) patients. A new classification of HLA-DRB1 alleles, reshaping the shared epitope (SE) hypothesis, was recently found relevant in terms of RA susceptibility and structural severity. We investigated the relevance of this new classification ...

Genetic variation in the odorant receptors family 13 and the mhc loci influence mate selection in a multiple sclerosis dataset

Background When selecting mates, many vertebrate species seek partners with major histocompatibility complex (MHC) genes different from their own, presumably in response to selective pressure against inbreeding and towards MHC diversity. Attempts at replication of these genetic results in human studies, however, have reached conflicting conclusions. Results Using a multi-analytical ...

Genetic contribution to multiple sclerosis risk among Ashkenazi Jews

Background Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, with a strong genetic component. Over 100 genetic loci have been implicated in susceptibility to MS in European populations, the most prominent being the 15:01 allele of the HLA-DRB1 gene. The prevalence of MS is high in European populations including those of Ashkenazi origin, and low in ...

Refining the association of MHC with multiple sclerosis in African Americans

. Oksenberg 2 Pierre-Antoine Gourraud 2 0 Department of Neurology, New York University Hospital for Joint Diseases , New York, NY 10003, USA 1 Robert S. Boas Center for Genomics and Human Genetics, Feinstein

Linkage disequilibrium organization of the human KIR superlocus: implications for KIR data analyses

analytical strategy. Anne Cambon- Thomsen contributed to the discussion and the manuscript. Derek Middleton and Pierre-Antoine Gourraud conceived the research and wrote the paper 1 ) Department of Neurology

Impact of meteorological conditions on the occurrence of acute type A aortic dissections

The impact of meteorological conditions on the occurrence of various cardiovascular events has been reported. The aim of this work was to study the correlations between weather conditions and the occurrence of type A acute aortic dissections (AADs). Between 1997 and 2007, all the medical records of patients who underwent surgery for type A AADs in Toulouse University Hospital ...

Fine-Mapping the Genetic Association of the Major Histocompatibility Complex in Multiple Sclerosis: HLA and Non-HLA Effects

The major histocompatibility complex (MHC) region is strongly associated with multiple sclerosis (MS) susceptibility. HLA-DRB1*15:01 has the strongest effect, and several other alleles have been reported at different levels of validation. Using SNP data from genome-wide studies, we imputed and tested classical alleles and amino acid polymorphisms in 8 classical human leukocyte ...

Highly conserved extended haplotypes of the major histocompatibility complex and their relationship to multiple sclerosis susceptibility

Khankhanian, Pierre-Antoine Gourraud, Nicolas Vince. 20 / 23 Software: Douglas S. Goodin, Pouya Khankhanian. Supervision: Douglas S. Goodin. Visualization: Douglas S. Goodin. Writing ± original draft ... : Douglas S. Goodin. Writing ± review & editing: Pouya Khankhanian, Pierre-Antoine Gourraud, Nicolas Vince. 21 / 23 22 / 23 1. Gourraud PA , Harbo HF , Hauser SL , Baranzini SE . ( 2012 ) The genetics of

HLA Diversity in the 1000 Genomes Dataset

The 1000 Genomes Project aims to provide a deep characterization of human genome sequence variation by sequencing at a level that should allow the genome-wide detection of most variants with frequencies as low as 1%. However, in the major histocompatibility complex (MHC), only the top 10 most frequent haplotypes are in the 1% frequency range whereas thousands of haplotypes are ...

Meta-Analysis Indicates That the European GWAS-Identified Risk SNP rs1344706 within ZNF804A Is Not Associated with Schizophrenia in Han Chinese Population

Recent genetic association studies have implicated several candidate susceptibility variants for schizophrenia among general populations. Rs1344706, an intronic SNP within ZNF804A, was identified as one of the most compelling candidate risk SNPs for schizophrenia in Europeans through genome-wide association studies (GWASs) and replications as well as large-scale meta-analyses. ...