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Cancer of unknown primary (CUP) is a metastasised cancer for which no primary lesion could be identified during life. Research into CUP aetiology with respect to dietary factors is particularly scarce. This study investigates whether meat consumption is associated with CUP risk. Data was utilised from the prospective Netherlands cohort study that includes 1,20,852 participants...
Mediterranean diet (MD) adherence has been associated with a large variety of health benefits. However, prospective studies investigating the relation between MD adherence and colorectal cancer risk had inconsistent results. In this analysis of the Netherlands Cohort Study (NLCS), we evaluated sex- and subsite-specific associations of MD adherence with colorectal cancer risk. In...
Study AuthorsAuthors and affiliations Piet A. van den Brandt Open Access MORTALITY First Online: 23 January 2019 68 Shares 771 Downloads Abstract Processed meat and red meat have been
Department of Epidemiology, CAPHRI-School for Public Health and Primary Care, Maastricht University Medical Centre , PO Box 616, 6200 MD Maastricht , The Netherlands 1 & Piet A. van den Brandt 2 Cohort studies
BackgroundMediterranean diet (MD) adherence has been associated with reduced risks of esophageal and gastric cancer (subtypes) in a limited number of studies. We prospectively investigated associations between MD adherence and risks of esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma (EAC), gastric cardia adenocarcinoma (GCA), and gastric non-cardia...
Primary Care, Maastricht University Medical Centre , Maastricht , The Netherlands 1 & Piet A. van den Brandt Smoking seems modestly associated with breast cancer, but the potential dual effect of smoking
Purpose Nut intake has been associated with reduced mortality and risk of cardiovascular diseases, but there is only limited evidence on cancer. We investigated the relationship between nut intake and risk of postmenopausal breast cancer, and estrogen/progesterone receptor (ER/PR) subtypes. Methods In The Netherlands Cohort Study, 62,573 women aged 55–69 years provided...
Purpose To date, the role of meat and fish intake in head–neck cancer (HNC) etiology is not well understood and prospective evidence is limited. This prompted us to study the association between meat, fish, and HNC subtypes, i.e., oral cavity cancer (OCC), oro- and hypopharyngeal cancer (OHPC), and laryngeal cancer (LC), within the Netherlands Cohort Study (NLCS). Methods In 1986...
Purpose of Review In this review, we describe molecular pathological epidemiology (MPE) studies from around the world that have studied diet and/or lifestyle factors in relation to molecular markers of (epi)genetic pathways in colorectal cancer (CRC), and explore future perspectives in this realm of research. The main focus of this review is diet and lifestyle factors for which...
, GROW - School for Oncology & Developmental Biology, Maastricht University, Maastricht, The NetherlandsDenise H. E. Maasland, Piet A. van den Brandt & Leo J. SchoutenDepartment of Otorhinolaryngology ... Research journals • PubMed • Google ScholarSearch for Piet A. van den Brandt in:Nature Research journals • PubMed • Google ScholarSearch for Bernd Kremer in:Nature Research journals • PubMed • Google
Some epidemiological studies observed a positive association between dietary acrylamide intake and ovarian cancer risk but the causality needs to be substantiated. By analyzing gene-acrylamide interactions for ovarian cancer risk for the first time, we aimed to contribute to this. The prospective Netherlands Cohort Study on diet and cancer includes 62,573 women, aged 55–69 years...
It is unclear whether the association between dietary acrylamide intake and endometrial cancer risk as observed in some epidemiological studies reflects a causal relationship. We aimed at clarifying the causality by analyzing acrylamide-gene interactions for endometrial cancer risk. The prospective Netherlands Cohort Study on diet and cancer includes 62,573 women, aged 55–69...
Background Prospective data on alcohol consumption, cigarette smoking and risk of head-neck cancer (HNC) subtypes, i.e. oral cavity cancer (OCC), oro-/hypopharyngeal cancer (OHPC), and laryngeal cancer (LC), are limited. We investigated these associations within the second largest prospective study on this topic so far, the Netherlands Cohort Study. Methods 120,852 participants...
AffiliationsDepartment of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The NetherlandsAnne M. J. Gilsing, Leo J. Schouten, Piet A. van den Brandt & Matty P ... Research journals • PubMed • Google ScholarSearch for Pieter C. Dagnelie in:Nature Research journals • PubMed • Google ScholarSearch for Piet A. van den Brandt in:Nature Research journals • PubMed • Google
PurposeThe role of diet in bladder carcinogenesis has yet to be established. To date most studies have investigated dietary components individually, rather than as dietary patterns, which may provide stronger evidence for any influence of diet on bladder carcinogenesis. The Mediterranean diet has been associated with many health benefits, but few studies have investigated its...
, MD, The NetherlandsDenise HE Maasland, Piet A van den Brandt & Leo J SchoutenDepartment of Otorhinolaryngology, Head & Neck Surgery, GROW - School for Oncology & Developmental Biology, Maastricht ... van den Brandt in:PubMed • Google Scholar Search for Bernd Kremer in:PubMed • Google Scholar Search for R Alexandra (Sandra) Goldbohm in:PubMed • Google Scholar Search for Leo J Schouten in:PubMed
Background In animal models, long-term moderate energy restriction (ER) is reported to decelerate carcinogenesis, whereas the effect of severe ER is inconsistent. The impact of early-life ER on cancer risk has never been reviewed systematically and quantitatively based on observational studies in humans. Objective We conducted a systematic review of observational studies and a...
We investigated the ion transport mechanism (ITM) in renal cell cancer (RCC) etiology using gene-environment interactions between candidate single nucleotide polymorphisms (SNPs) and associated environmental factors, including dietary intakes of sodium, potassium and fluid, hypertension and diuretic medication. A literature-based selection of 13 SNPs in ten ITM genes were...
