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Design of Accelerated Life Test Plans—Overview and Prospect

‑ ability Technology for Mechanical and Electrical Product of Zhejiang Province, Zhejiang Sci‑ Tech University, China. Ping Qian, born in 1983, is currently an associate professor at Key Labora‑ tory of

bmo-miR-275 down-regulates expression of Bombyx mori sericin gene 2 in vitro

miRNAs in the 50UTRs of potential mRNA targets. Author Contributions Conceptualization: Ping Qian. Data curation: Ping Qian. Formal analysis: Ping Qian. Funding acquisition: Ping Qian, Xingjia Shen ... . Investigation: Ping Qian, Tao Jiang, Xin Wang, Fei Song, Chen Chen. Methodology: Ping Qian. Project administration: Xingjia Shen. Resources: Ping Qian, Xingjia Shen. Supervision: Xingjia Shen. Validation

Isolation and full-genome sequencing of Seneca Valley virus in piglets from China, 2016

Background Seneca valley virus (SVV), a member of the Picornaviridae family, is a small non-enveloped RNA virus, that is linked to porcine idiopathic vesicular disease (PIVD). SVV infection in swine results in vesicular disease and epidemic transient neonatal losses (ETNL). The first case of SVV infection was reported in Guangdong, South China in 2015. Results We isolated and...

Construction and immune efficacy of recombinant pseudorabies virus expressing PrM-E proteins of Japanese encephalitis virus genotype І

Background Japanese encephalitis (JE) is an arboviral disease with high case fatality rates and neurologic or psychiatric sequelae among survivors in Asia, western Pacific countries and northern Australia. Japanese encephalitis virus (JEV) is the cause of JE and the emergence of genotype І (GI) JEV has displaced genotype III (GIII) as the dominant strains circulating in some...

JAK2 inhibitor combined with DC-activated AFP-specific T-cells enhances antitumor function in a Fas/FasL signal-independent pathway

JAK2 inhibitor combined with DC-activated AFP-specific T-cells enhances tantitumor function in a Fas/FasL signal-independent pathway Yang Liu,1 Yue-ru Wang,2 Guang-hui Ding,1 Ting-song Yang,1 Le Yao,1 Jie Hua,1 Zhi-gang He,1 Ming-ping Qian1 1Department of Hepatobiliary Surgery, Shanghai 10th People’s Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of...

bmo-miR-0001 and bmo-miR-0015 down-regulate expression of Bombyx mori fibroin light chain gene in vitro

mechanisms of silk protein biosynthesis. Compliance with ethics guidelines Chen CHEN, Yang-yang FAN, Xin WANG, Fei SONG, Tao JIANG, Ping QIAN, Shun-ming TANG, and Xing-jia SHEN declare that they have no

Mesenchymal adenomatous polyposis coli plays critical and diverse roles in regulating lung development

Background Adenomatous polyposis coli (Apc) is a tumor suppressor that inhibits Wnt/Ctnnb1. Mutations of Apc will not only lead to familial adenomatous polyposis with associated epithelial lesions, but will also cause aggressive fibromatosis in mesenchymal cells. However, the roles of Apc in regulating mesenchymal cell biology and organogenesis during development are unknown...

Isolation and molecular characterization of genotype 1 Japanese encephalitis virus, SX09S-01, from pigs in China

Ping Qian 0 1 0 State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University , Wuhan city 430070, Hubei Province , P. R. China 1 Laboratory of Animal Virology, College of

Maternal diabetes causes abnormal dynamic changes of endoplasmic reticulum during mouse oocyte maturation and early embryo development

Background The adverse effects of maternal diabetes on oocyte maturation and embryo development have been reported. Methods In this study, we used time-lapse live cell imaging confocal microscopy to investigate the dynamic changes of ER and the effects of diabetes on the ER’s structural dynamics during oocyte maturation, fertilization and early embryo development. Results We...

Heterogeneity within medullary-type TCRαβ+CD3+CD4–CD8+ thymocytes in normal mouse thymus

The functional maturation process of medullary-type CD4–CD8+ [CD8 single-positive (SP)] thymocytes remains largely uncharacterized. We describe a phenotypic analysis of CD8 SP medullary-type thymocytes and find a remarkable heterogeneity within this thymic cell population. While mature CD8+ T cells in the periphery are relatively homogenous (TCRαβ+CD3+Qa-2+ HSA–3G11–6C10–CD69...

Recent Origin of a Hominoid-Specific Splice Form of Neuropsin, a Gene Involved in Learning and Memory

Neuropsin is a secreted-type serine protease involved in learning and memory. The type II splice form of neuropsin is abundantly expressed in the human brain but not in the mouse brain. We sequenced the type II–spliced region of neuropsin gene in humans and representative nonhuman primate species. Our comparative sequence analysis showed that only the hominoid species (humans and...