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17 papers found.
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No difference in effectiveness of treatment simplification to boosted or unboosted atazanavir plus lamivudine in virologically suppressed in HIV-1-infected patients

LoÂpez-CorteÂs. Investigation: Alicia Gutierrez-Valencia, Coral GarcÂõa, Pompeyo Viciana, Yusnelkis MilaneÂs Guisado, Tamara Fernandez-Magdaleno, Juan Pasquau, Luis Fernando LoÂpez-CorteÂs. Methodology

No evidence of firstly acquired acute hepatitis C virus infection outbreak among HIV-infected patients from Southern Spain: a multicentric retrospective study from 2000-2014

Background Acute hepatitis C virus (HCV) infection (AHCVI) outbreaks have been described recently within defined areas worldwide among HIV-infected homosexual men. This study aims to describe the cumulative frequency and incidence of firstly acquired AHCVI in an HIV-infected population in Southern Spain. Methods This is a retrospective study conducted at the Infectious Diseases...

Effectiveness of Ritonavir-Boosted Protease Inhibitor Monotherapy in Clinical Practice Even with Previous Virological Failures to Protease Inhibitor-Based Regimens

Background and Objective Significant controversy still exists about ritonavir-boosted protease inhibitor monotherapy (mtPI/rtv) as a simplification strategy that is used up to now to treat patients that have not experienced previous virological failure (VF) while on protease inhibitor (PI) -based regimens. We have evaluated the effectiveness of two mtPI/rtv regimens in an actual...

HCV Viral Decline at Week 2 of Peg-IFN-Alpha-2a/RBV Therapy as a Predictive Tool for Tailoring Treatment in HIV/HCV Genotype 1 Co-Infected Patients

Background Optimizing HCV genotype 1 therapy in terms of response prediction and tailoring treatment is undoubtedly the cornerstone of treating HIV co-infected patients in clinical practice. Accordingly, our aim was to analyze the predictive value of HCV viral decline for sustained virological response (SVR), measured at a time point as early as week 2 of therapy with pegylated...

Role of Ritonavir in the Drug Interactions Between Telaprevir and Ritonavir-Boosted Atazanavir

Background. Detrimental bidirectional pharmacokinetic interactions have been observed when telaprevir (TVR) and ritonavir (RTV)-boosted human immunodeficiency virus (HIV) protease inhibitors are coadministered in healthy volunteers. Our aim was to evaluate the role of RTV in the bidirectional TVR and atazanavir (ATV) interactions. Method. An open-label, sequential study was...

What Drives the Number of High-Risk Human Papillomavirus Types in the Anal Canal in HIV-Positive Men Who Have Sex With Men?

; Hospital Universitario Virgen del Roco, Sevilla: Pompeyo Viciana, Mnica Trastoy, and Maria Fontilln; Hospital Universitario de Elche, Alicante: Mar Masi, Catalina Robledano, Flix Gutierrez, Sergio Padilla

Clinical and Virological Efficacy of Etravirine Plus Two Active Nucleos(t)ide Analogs in an Heterogeneous HIV-Infected Population

-Cortes, Pompeyo Viciana, Jose A. Giro n-Gonzalez, Manuel Marquez-Solero, Javier de la Torre-Lima, Marcial Delgado-Fernandez, and Fernando Lozano have received honoraria for speaking at symposia organized

IL28B Single-Nucleotide Polymorphism rs12979860 Is Associated With Spontaneous HIV Control in White Subjects

Machmach, Sara Ferrando-Martnez, Miguel Genebat, Pompeyo Viciana, Manuel Leal, Jose Miguel Benito, Mariola Lpez, Norma Ralln, Clara Restrepo, Cecilio Lpez-Galindez, Maria Pernas, Concha Casado, Agathe Len

Increased Regulatory T Cell Counts in HIV-Infected Nonresponders to Hepatitis B Virus Vaccine

Hepatitis B virus (HBV) coinfection is a main cause of liver-related mortality in human immunodeficiency virus (HIV)-infected subjects. Unfortunately, HIV-infected subjects show a low rate of response to standard HBV vaccination (23%–56%), in contrast to rates >90% found in the general population, and the underlying causes (particularly cellular and molecular causes) are still...

Prevalence and resistance mutations of non-B HIV-1 subtypes among immigrants in Southern Spain along the decade 2000-2010

Background Most of the non-B HIV-1 subtypes are predominant in Sub-Saharan Africa and India although they have been found worldwide. In the last decade, immigration from these areas has increased considerably in Spain. The objective of this study was to evaluate the prevalence of non-B subtypes circulating in a cohort of HIV-1-infected immigrants in Seville, Southern Spain and to...

Influence of IL28B Polymorphisms on Response to a Lower-Than-Standard Dose peg-IFN-α 2a for Genotype 3 Chronic Hepatitis C in HIV-Coinfected Patients

Background Data on which to base definitive recommendations on the doses and duration of therapy for genotype 3 HCV/HIV-coinfected patients are scarce. We evaluated the efficacy of a lower peginterferon-α 2a dose and a shorter duration of therapy than the current standard of care in genotype 3 HCV/HIV-coinfected patients. Methods and Findings Pilot, open-label, single arm...

Dyslipidaemia in HIV-infected women on antiretroviral therapy. Analysis of 922 patients from the Spanish VACH cohort

17 María Luisa García Alcalde 24 María Rodrigo 23 María José Galindo 22 Agustín Muñoz 21 Pere Domingo 26 Esteve Ribera 25 Jaime Cosín 19 Pompeyo Viciana 8 Fernando Lozano 9 Alberto Terrón 6 Antonio

Eligibility for and outcome of treatment of latent tuberculosis infection in a cohort of HIV-infected people in Spain

Santiago Moreno Maria Elena Moreno Pablo Labarga Javier Pinilla Joseba Portu 0 Federico Pulido 4 Carmen Rosa 7 Juan Miguel Santamara 3 Mauricio Telenti Luis Trapiella Monica Trastoy Pompeyo Viciana 0

Clinical Outcome of HIV-Infected Patients with Sustained Virologic Response to Antiretroviral Therapy: Long-Term Follow-Up of a Multicenter Cohort

Background Limited information exists on long-term prognosis of patients with sustained virologic response to antiretroviral therapy. We aimed to assess predictors of unfavorable clinical outcome in patients who maintain viral suppression with HAART. Methods Using data collected from ten clinic-based cohorts in Spain, we selected all antiretroviral-naive adults who initiated...

Comparison of Two Methods for the Assessment of Delayed-Type Hypersensitivity Skin Responses in Patients with Human Immunodeficiency Virus Infection

We compared two techniques for detecting delayed-type hypersensitivity (DTH) skin responses in 359 patients infected with human immunodeficiency virus (HIV) (mean CD4/+ lymphocyte count, 387/µL). DTH responses were assessed with use of two antigenic panels administered simultaneously: tuberculin purified protein derivative (PPD) plus three control antigens (Candida albicans...

Etiology of Solitary Pulmonary Nodules in Patients with Human Immunodeficiency Virus Infection

We assessed 10 patients with human immunodeficiency virus (HIV) infection (nine of whom had AIDS) and solitary pulmonary nodules (SPNs) that were detected on roentgenograms. Five of the patients presented with respiratory symptoms. The etiology of the SPN was determined for eight of these patients: six had infections (hydatidosis, mucormycosis, or infection with Nocardia...

The Use of Transient Elastometry for Assessing Liver Fibrosis in Patients with HIV and Hepatitis C Virus Coinfection

Background. Transient elastometry (TE) is accurate for detecting significant liver fibrosis and cirrhosis in hepatitis C virus (HCV)–monoinfected patients. However, this procedure has been insufficiently validated in patients with human immunodeficiency virus (HIV) and HCV coinfection. The purpose of this study was to validate reported cutoff values of TE that discriminate...