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Prediction of novel target genes and pathways involved in bevacizumab-resistant colorectal cancer

. Data curation: Precious Takondwa Makondi, Chia-Hwa Lee, Yu-Jia Chang. Investigation: Precious Takondwa Makondi, Chi-Ming Chu, Po-Li Wei. S2 Table. Up-regulated genes. (DOCX) Author Contributions Formal ... analysis: Chi-Ming Chu. Funding acquisition: Po-Li Wei. Methodology: Chi-Ming Chu. Project administration: Yu-Jia Chang. Resources: Yu-Jia Chang, Po-Li Wei. Software: Precious Takondwa Makondi

Prediction of novel target genes and pathways involved in irinotecan-resistant colorectal cancer

Background Acquired drug resistance to the chemotherapeutic drug irinotecan (the active metabolite of which is SN-38) is one of the significant obstacles in the treatment of advanced colorectal cancer (CRC). The molecular mechanism or targets mediating irinotecan resistance are still unclear. It is urgent to find the irinotecan response biomarkers to improve CRC patients’ therapy. ...